PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31357761-9	2019	SP600125 and SB203580 had inhibited oxidative stress and apoptosis induced by palmitic acid (including CYP2E1, MDA, Bax, Bcl-2, caspase3, CHOP) (P< 0.05).	Palmitic Acid	78-91	BCL2 apoptosis regulator	Homo sapiens	121-126	
31839747-7	2019	LPS+PA treatment group significantly decreases the relative expression level of IRS-1, PI3K, AKT, phosphorylation of AKT, TLR-4, MyD88, phosphorylation of IKKalpha, NF-kappaB, Bcl-2 and increases the relative expression level of Bax, cleaved caspase 3 and cleaved caspase 8, compared with the cells treated with NAFLD model.	Palmitic Acid	4-6	BCL2 apoptosis regulator	Homo sapiens	176-181	
31197979-10	2020	Consistently, KL protein reversed the expression levels of the increased pro-apoptotic protein Bax and the decreased anti-apoptotic protein Bcl-2 induced by PA.	Palmitic Acid	157-159	BCL2 apoptosis regulator	Homo sapiens	140-145	
21929682-5	2012	Additionally, melatonin effectively suppressed PA-induced reactive oxygen species generation and prevented PA-induced apoptosis whereby the rise in Bax/Bcl-2 ratio and caspase-3 activation in astroglial cells was inhibited.	Palmitic Acid	107-109	BCL2 apoptosis regulator	Homo sapiens	152-157	
30064425-8	2018	The ratio of Bax/Bcl-2 and cleaved caspase-3, two markers of apoptosis were upregulated by PA or cholesterol treatment.	Palmitic Acid	91-93	BCL2 apoptosis regulator	Homo sapiens	17-22	
23319068-4	2013	Increased protein levels of Bax and cleaved caspase 3 coupled with decreased expression of Bcl-2 were also observed in NSCs with increasing dose or time of PA treatment, whereas caspase 3 expression remained relatively unaltered.	Palmitic Acid	156-158	BCL2 apoptosis regulator	Homo sapiens	91-96	
29323715-9	2018	PA treatment also suppressed the interaction between BCL-2 and IP3R in HepG2 cells, whereas this interaction was massively enhanced in the ALR-Tx cells, effectively reducing the IP3R-mediated ER-Ca2+ release and thus mitochondrial Ca2+ influx.	Palmitic Acid	0-2	BCL2 apoptosis regulator	Homo sapiens	53-58	
23480852-4	2013	In the present study we demonstrate that direct inhibition of anti-apoptotic BCL2 proteins with ABT-263 is sufficient to induce C(16)-ceramide synthesis in multiple cell lines, including human leukaemia and myeloma cells.	Palmitic Acid	128-133	BCL2 apoptosis regulator	Homo sapiens	77-81	
22311471-8	2012	Moreover, 2-DCB and PA also induced Bax up-regulation, the reduction in Bcl-2 expression level, Bid cleavage and the release of cytochrome c from the mitochondria to the cytosol.	Palmitic Acid	20-22	BCL2 apoptosis regulator	Homo sapiens	72-77	
20506110-12	2010	Moreover, PA increased the Bax/Bcl-2 ratio, cleaved PARP, and caspase-3 levels.	Palmitic Acid	10-12	BCL2 apoptosis regulator	Homo sapiens	31-36	
15663230-8	2004	CONCLUSION: PA may induce cell death on hepatocytes via mitochondria-mediated apoptosis by reducing the level of Bcl-2/Bax.	Palmitic Acid	12-14	BCL2 apoptosis regulator	Homo sapiens	113-118	
15945276-4	2005	The level of Bcl-2 was slightly decreased, in contrast, the level of Bax elevated markedly, which resulted in a significant decrease of Bcl-2/Bax ratio after PA treatment on HepG2 cells.	Palmitic Acid	158-160	BCL2 apoptosis regulator	Homo sapiens	13-18	
15945276-4	2005	The level of Bcl-2 was slightly decreased, in contrast, the level of Bax elevated markedly, which resulted in a significant decrease of Bcl-2/Bax ratio after PA treatment on HepG2 cells.	Palmitic Acid	158-160	BCL2 apoptosis regulator	Homo sapiens	136-141	
12606514-8	2003	In addition, palmitic acid decreased Bcl-2 expression and induced release of cytochrome c from the mitochondria into the cytosol, which was prevented by fumonisin B1 and by oleic acid.	Palmitic Acid	13-26	BCL2 apoptosis regulator	Homo sapiens	37-42	
11459807-9	2001	A Western blot analysis showed the apoptosis of the granulosa cells induced by palmitic acid to be accompanied by the down-regulation of an apoptosis inhibitor, Bcl-2, and the up-regulation of an apoptosis effector, Bax.	Palmitic Acid	79-92	BCL2 apoptosis regulator	Homo sapiens	161-166