PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30387829-7	2018	The results demonstrated that PA effectively activated NLRP3 inflammasome and increased the expression and secretion of interleukin (IL)-1beta and IL-18.	Palmitic Acid	30-32	interleukin 18	Mus musculus	147-152	
30700851-10	2019	Along with impaired mitophagy, mRNA and protein levels of NLRP3, caspase-1, IL-18 and IL-1beta were upregulated by PA treatment.	Palmitic Acid	115-117	interleukin 18	Mus musculus	76-81	
30791996-6	2019	High glucose and palmitic acid treatment enhanced the expression of interleukin-1beta and interleukin-18; these enhancements were further increased after treatment with DsbA-L siRNA but alleviated by co-treatment with an AMPK activator.	Palmitic Acid	17-30	interleukin 18	Mus musculus	90-104	
34107901-8	2021	RESULTS: Podocytes treated with palmitic acid (PA) showed downregulated expressions of podocyte markers, increased apoptosis, upregulated levels of NLRP3 inflammasome-related proteins, increased production of inflammatory cytokines (IL-18 and IL-1beta), and induced activation of NF-kappaB as compared to the vehicle-treated controls.	Palmitic Acid	32-45	interleukin 18	Mus musculus	233-238	
34107901-8	2021	RESULTS: Podocytes treated with palmitic acid (PA) showed downregulated expressions of podocyte markers, increased apoptosis, upregulated levels of NLRP3 inflammasome-related proteins, increased production of inflammatory cytokines (IL-18 and IL-1beta), and induced activation of NF-kappaB as compared to the vehicle-treated controls.	Palmitic Acid	47-49	interleukin 18	Mus musculus	233-238	
30387829-8	2018	Notably, the PA-induced inflammasome activation was reversed by Nob, as indicated by the decreased expression levels of NLRP3, Caspase-1, IL-1beta and IL-18.	Palmitic Acid	13-15	interleukin 18	Mus musculus	151-156	
28730512-9	2017	We found that KCs and NLRP3 play pro-inflammatory roles in the progression of NASH, probably through secretions of IL-1beta and IL-18 by KCs induced by PA.	Palmitic Acid	152-154	interleukin 18	Mus musculus	128-133	
28730512-12	2017	Furthermore, the levels of pro-inflammatory cytokines IL-1beta and IL-18 in the SN of KCs from WT mice were all elevated with the stimulation of PA, and the increase of these cytokines in the SN was blocked by NLRP3 deletion.	Palmitic Acid	145-147	interleukin 18	Mus musculus	67-72	
28730512-13	2017	In conclusion, our novel findings demonstrate that NLRP3 plays a pivotal role in NASH development and pro-inflammatory cytokines IL-1beta and IL-18 secretion induced by PA stimulation, and NLRP3 might be an effective potential target for the treatment of liver inflammatory diseases associated with NLRP3 inflammasome activation.	Palmitic Acid	169-171	interleukin 18	Mus musculus	142-147