PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28510423-8 2017 Further mechanistic studies demonstrated that PA induced overproduction of intracellular ROS, mitochondria fragmentation, activation of caspase-3, -8, and -9, and cleavage of PARP. Palmitic Acid 46-48 caspase 3 Rattus norvegicus 136-157 31149020-9 2019 We also found that PA impaired the balance of BCL2 family proteins, destabilized mitochondrial membrane potential, and triggered subsequent cytochrome c release into the cytosol and activation of caspase 3. Palmitic Acid 19-21 caspase 3 Rattus norvegicus 196-205 26203862-6 2015 CA also counteracted the HFD- or palmitic acid (PA)-induced increases in caspase-3 and caspase-9 activity. Palmitic Acid 33-46 caspase 3 Rattus norvegicus 73-82 26203862-6 2015 CA also counteracted the HFD- or palmitic acid (PA)-induced increases in caspase-3 and caspase-9 activity. Palmitic Acid 48-50 caspase 3 Rattus norvegicus 73-82 21753123-6 2011 Consistent with these results, caspase-3 activity and BAX and sterol regulatory element binding protein-1c (SREBP-1c) mRNA levels were markedly increased in INS-1 cells co-administered palmitic acid and T0901317. Palmitic Acid 185-198 caspase 3 Rattus norvegicus 31-40 17194744-9 2007 In isolated rat islets, the effect of palmitic acid on caspase-3/7 activity was increased with T0901317 alone and even more with the combination of T0901317 and 9cRA. Palmitic Acid 38-51 caspase 3 Rattus norvegicus 55-64 30859861-4 2019 Treatment with PA reduced cell viability, induced apoptosis, enhanced apoptosis-related protein expression (Caspase 3 and BCL-2 associated X protein (BAX)), and activated ER stress marker protein expression (glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP)). Palmitic Acid 15-17 caspase 3 Rattus norvegicus 108-117 30859861-5 2019 Curcumin attenuated PA-induced reduction in cell viability and activation of apoptosis, Caspase 3 activity, BAX, CHOP, and GRP78 expression. Palmitic Acid 20-22 caspase 3 Rattus norvegicus 88-97 23440052-5 2013 OLA significantly attenuated the PAM-induced increase in the levels of pro-apoptotic Bak protein, cleaved forms of apoptotic proteins (caspase-3, PARP). Palmitic Acid 33-36 caspase 3 Rattus norvegicus 135-144 19463182-6 2009 ConA-stimulated LNC or Sn and PA cooperated in inducing caspase-3-dependent RIN cell apoptosis. Palmitic Acid 30-32 caspase 3 Rattus norvegicus 56-65 35615578-9 2022 YBS, palmitic acid, and cinnamate reduced the expression of substance P, CGRP, S100A9, CTSW, and cleaved caspase-3, while enhancing the expression of CDKN1A, UHRF1, PCNA, Ki67, SOCS3, DCN, LEPR, and BCL2A1, as well as telomerase activity. Palmitic Acid 5-18 caspase 3 Rattus norvegicus 105-114