PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35615578-9	2022	YBS, palmitic acid, and cinnamate reduced the expression of substance P, CGRP, S100A9, CTSW, and cleaved caspase-3, while enhancing the expression of CDKN1A, UHRF1, PCNA, Ki67, SOCS3, DCN, LEPR, and BCL2A1, as well as telomerase activity.	Palmitic Acid	5-18	caspase 3	Rattus norvegicus	105-114	
28510423-8	2017	Further mechanistic studies demonstrated that PA induced overproduction of intracellular ROS, mitochondria fragmentation, activation of caspase-3, -8, and -9, and cleavage of PARP.	Palmitic Acid	46-48	caspase 3	Rattus norvegicus	136-157	
30859861-4	2019	Treatment with PA reduced cell viability, induced apoptosis, enhanced apoptosis-related protein expression (Caspase 3 and BCL-2 associated X protein (BAX)), and activated ER stress marker protein expression (glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP)).	Palmitic Acid	15-17	caspase 3	Rattus norvegicus	108-117	
30859861-5	2019	Curcumin attenuated PA-induced reduction in cell viability and activation of apoptosis, Caspase 3 activity, BAX, CHOP, and GRP78 expression.	Palmitic Acid	20-22	caspase 3	Rattus norvegicus	88-97	
31149020-9	2019	We also found that PA impaired the balance of BCL2 family proteins, destabilized mitochondrial membrane potential, and triggered subsequent cytochrome c release into the cytosol and activation of caspase 3.	Palmitic Acid	19-21	caspase 3	Rattus norvegicus	196-205	
23440052-5	2013	OLA significantly attenuated the PAM-induced increase in the levels of pro-apoptotic Bak protein, cleaved forms of apoptotic proteins (caspase-3, PARP).	Palmitic Acid	33-36	caspase 3	Rattus norvegicus	135-144	
26203862-6	2015	CA also counteracted the HFD- or palmitic acid (PA)-induced increases in caspase-3 and caspase-9 activity.	Palmitic Acid	33-46	caspase 3	Rattus norvegicus	73-82	
26203862-6	2015	CA also counteracted the HFD- or palmitic acid (PA)-induced increases in caspase-3 and caspase-9 activity.	Palmitic Acid	48-50	caspase 3	Rattus norvegicus	73-82	
21753123-6	2011	Consistent with these results, caspase-3 activity and BAX and sterol regulatory element binding protein-1c (SREBP-1c) mRNA levels were markedly increased in INS-1 cells co-administered palmitic acid and T0901317.	Palmitic Acid	185-198	caspase 3	Rattus norvegicus	31-40	
17194744-9	2007	In isolated rat islets, the effect of palmitic acid on caspase-3/7 activity was increased with T0901317 alone and even more with the combination of T0901317 and 9cRA.	Palmitic Acid	38-51	caspase 3	Rattus norvegicus	55-64	
19463182-6	2009	ConA-stimulated LNC or Sn and PA cooperated in inducing caspase-3-dependent RIN cell apoptosis.	Palmitic Acid	30-32	caspase 3	Rattus norvegicus	56-65