PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11303593-2	2001	CYP3A4 catalyzes the formation of the genotoxic estrogen, 16alpha-hydroxyestrone.	16-hydroxyestrone	58-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6	
9635876-4	1998	E1 metabolism to 16alpha-OHE1 in a panel of 15 human liver microsomal preparations correlated with total P450 concentrations (r2 = 0.63) and with activities associated with P450 forms CYP3A4 and 3A5 (r2 = 0.72).	16-hydroxyestrone	17-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	184-190	
9635876-7	1998	Microsomal preparations of cDNA expressed CYP3A4 or 3A5, with NADPH-P450-reductase co-expressed, both metabolized E1 to 16alpha-OHE1, and added cytochrome b5 increased the rates 5.1- and 7.5-fold, respectively.	16-hydroxyestrone	120-132	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	42-48