PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11303593-2 2001 CYP3A4 catalyzes the formation of the genotoxic estrogen, 16alpha-hydroxyestrone. 16-hydroxyestrone 58-80 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 9635876-4 1998 E1 metabolism to 16alpha-OHE1 in a panel of 15 human liver microsomal preparations correlated with total P450 concentrations (r2 = 0.63) and with activities associated with P450 forms CYP3A4 and 3A5 (r2 = 0.72). 16-hydroxyestrone 17-29 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 184-190 9635876-7 1998 Microsomal preparations of cDNA expressed CYP3A4 or 3A5, with NADPH-P450-reductase co-expressed, both metabolized E1 to 16alpha-OHE1, and added cytochrome b5 increased the rates 5.1- and 7.5-fold, respectively. 16-hydroxyestrone 120-132 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 42-48