PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32148809-3 2020 In a rat model of d-galactosamine(GalN)/LPS-induced liver injury, the survival was significantly higher in animals treated with D-18-007 than in animals treated with LAFGE. Galactosamine 18-33 galanin and GMAP prepropeptide Rattus norvegicus 34-38 32842550-4 2020 Administration of the hepatotoxin lipopolysaccharide/D-Galactosamine (LPS/GalN) resulted in marked liver injury in WKY, but not SD rats, with increased alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glutamate dehydrogenase (GLDH) plasma levels, significant histopathological changes, increased hepatic pro-inflammatory cytokine expression and caspase-3 activity and expression and reduced Glutathione (GSH) activity. Galactosamine 53-68 galanin and GMAP prepropeptide Rattus norvegicus 74-78 31022331-2 2019 d-Galactosamine (d-GalN)-induced liver toxicity causes damage to brain. Galactosamine 0-15 galanin and GMAP prepropeptide Rattus norvegicus 19-23 31920708-4 2019 Methods: ACLF model was established by challenging D-galactosamine (D-GalN)/ lipopolysaccharide (LPS) i.p. Galactosamine 51-66 galanin and GMAP prepropeptide Rattus norvegicus 70-74 31616509-4 2019 The aim of this study was to explore the protective effects of crocetin against lipopolysac charide (LPS)/D-galactosamine (D-GalN)-induced FHF and the underlying mechanisms in a rat model. Galactosamine 107-122 galanin and GMAP prepropeptide Rattus norvegicus 126-130 31281594-4 2019 A combination of D-galactosamine and lipopolysaccharide (D-GalN/LPS) downregulated SIRT1 expression, while SIRT1 activators, SRT1720, resveratrol, and quercetin, upregulated SIRT1 and alleviated D-GalN/LPS-induced acute hepatotoxicity. Galactosamine 17-32 galanin and GMAP prepropeptide Rattus norvegicus 59-63 31281594-4 2019 A combination of D-galactosamine and lipopolysaccharide (D-GalN/LPS) downregulated SIRT1 expression, while SIRT1 activators, SRT1720, resveratrol, and quercetin, upregulated SIRT1 and alleviated D-GalN/LPS-induced acute hepatotoxicity. Galactosamine 17-32 galanin and GMAP prepropeptide Rattus norvegicus 197-201 28224477-2 2018 Previously, we demonstrated hepatoprotective effects of genistein in D-galactosamine (D-GalN)-induced fulminant hepatic failure (FHF). Galactosamine 69-84 galanin and GMAP prepropeptide Rattus norvegicus 88-92 31402229-2 2019 Its inhibitor genistein attenuated D-galactosamine (D-GalN)-induced liver damage. Galactosamine 35-50 galanin and GMAP prepropeptide Rattus norvegicus 54-58 30337815-7 2018 Twenty-four h after the last administration, rats were challenged with D-galactosamine (D-GalN)/lipopolysaccharide (LPS). Galactosamine 71-86 galanin and GMAP prepropeptide Rattus norvegicus 90-94 30253710-1 2018 d-galactosamine (d-GalN) is a well-known hepatotoxic agent that causes liver injury. Galactosamine 0-15 galanin and GMAP prepropeptide Rattus norvegicus 19-23 30809090-2 2019 The aim of this study was to investigate the amelioration efficacy of JDHY in lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced ALF in rat and explore the possible molecular mechanism underlying the therapeutic efficacy. Galactosamine 97-112 galanin and GMAP prepropeptide Rattus norvegicus 120-124 28758404-2 2017 d-Galactosamine/lipopolysaccharide (d-GalN/LPS)-induced FHF is a renowned model to evaluate the efficacy of hepatoprotective agents. Galactosamine 0-15 galanin and GMAP prepropeptide Rattus norvegicus 38-42 28885586-7 2017 Additionally, the extract showed a remarkable hepatoprotective activity against d-galactosamine (d-GalN) induced hepatic injury in rats. Galactosamine 80-95 galanin and GMAP prepropeptide Rattus norvegicus 99-103 28479727-4 2017 OBJECTIVE: The present study was designed to explore the antioxidant property of (-)-epicatechin isolated from PN in D-Galactosamine (D-GalN) induced hepatitis rats. Galactosamine 117-132 galanin and GMAP prepropeptide Rattus norvegicus 136-140 28448872-2 2017 In this study, the hepatoprotective effect of curcumin was investigated in lipopolysaccharide (LPS)/d-galactosamine (d-GalN)-induced acute liver injury (ALI) in rats. Galactosamine 100-115 galanin and GMAP prepropeptide Rattus norvegicus 119-123 27876602-3 2017 Previously we demonstrated the protective effects of Genistein in d-Galactosamine (D-GalN) induced fulminant hepatic failure (FHF) in rats. Galactosamine 66-81 galanin and GMAP prepropeptide Rattus norvegicus 85-89 28197212-2 2017 To investigate the preventative effects of Jiedu Huayu (JDHY) on D-galactosamine (D-GalN) and lipopolysaccharide-induced acute liver failure (ALF) and to evaluate the possible mechanisms of action. Galactosamine 65-80 galanin and GMAP prepropeptide Rattus norvegicus 84-88 27836788-2 2016 We previously reported the hepatoprotective effect of Glycine propionyl-l-carnitine (GPLC) against the fulminant hepatic failure (FHF) induced by d-Galactosamine (D-GalN). Galactosamine 146-161 galanin and GMAP prepropeptide Rattus norvegicus 165-169 26660314-1 2016 D-Galactosamine (D-GalN), which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. Galactosamine 0-15 galanin and GMAP prepropeptide Rattus norvegicus 19-23 25859783-3 2015 In in vitro assays, compounds 2-4, 6 and 11 showed significant hepatoprotective activities by lowering the ALT and AST levels in primary rat hepatocytes injured by D-galactosamine (D-GalN). Galactosamine 164-179 galanin and GMAP prepropeptide Rattus norvegicus 183-187 27226100-1 2016 BACKGROUND: Our aim in this study is to investigate the effect of protocatechuic acid (PCA) on lipid profile and DNA damage in D-galactosamine (D-GalN)-induced hepatotoxic rats. Galactosamine 127-142 galanin and GMAP prepropeptide Rattus norvegicus 146-150 26401074-7 2015 In experiments using acute liver injury models, 1000 mg/kg acetaminophen (APAP) or 350 mg/kg D-galactosamine (D-GalN) was used to induce injury. Galactosamine 93-108 galanin and GMAP prepropeptide Rattus norvegicus 112-116 25620059-3 2015 In this study, we evaluated potential therapeutic properties of Genistein against d-Galactosamine (d-GalN) induced inflammation and hepatotoxicity in male Wistar rats. Galactosamine 82-97 galanin and GMAP prepropeptide Rattus norvegicus 101-105 25170215-2 2014 METHODS: Acute liver injury in rats was induced by a single intraperitoneal injection of D-galactosamine (D-GalN). Galactosamine 89-104 galanin and GMAP prepropeptide Rattus norvegicus 108-112 25499312-3 2015 MATERIAL AND METHODS: Acute liver failure was induced by intraperitoneal injection of d-galactosamine (d-GalN) into specific pathogen-free male Wistar rats. Galactosamine 86-101 galanin and GMAP prepropeptide Rattus norvegicus 105-109 25400741-3 2014 The current study aimed to investigate the protecting mechanisms of endotoxin tolerance in acute liver failure induced by D-galactosamine (D-GalN)/LPS and possible role of toll-like receptors 4 (TLR4) signaling pathway in this phenomenon. Galactosamine 122-137 galanin and GMAP prepropeptide Rattus norvegicus 141-145 24565947-2 2014 The present study evaluated hepatoprotective effect of GPLC in d-Galactosamine (d-GalN) induced fulminant hepatic failure. Galactosamine 63-78 galanin and GMAP prepropeptide Rattus norvegicus 82-86 22978659-2 2012 OBJECTIVES: The present investigation was to demonstrate the protective effect of the methanol extract of B. nigra leaves against D-galactosamine (D-GalN)-induced hepatic and nephrotoxicity in Wistar rats. Galactosamine 130-145 galanin and GMAP prepropeptide Rattus norvegicus 149-153 24987711-2 2014 ALF was induced in rats by administration of D-galactosamine (D-GalN)/lipopolysaccharide (LPS). Galactosamine 45-60 galanin and GMAP prepropeptide Rattus norvegicus 64-68 24908092-1 2014 D-Galactosamine/Lipopolysaccharide (D-GalN/LPS) is a well known model of hepatotoxicity that closely resembles acute liver failure (ALF) seen clinically. Galactosamine 0-15 galanin and GMAP prepropeptide Rattus norvegicus 38-42 23874752-6 2013 ACLF was induced with D-galactosamine (D-GalN)/lipopolysaccharide (LPS) i.p. Galactosamine 22-37 galanin and GMAP prepropeptide Rattus norvegicus 41-45 25371573-3 2014 The present study investigates the influence of carvacrol on CYP2E1 and PPAR-alpha on D-Galactosamine (D-GalN)-induced hepatotoxic rats. Galactosamine 86-101 galanin and GMAP prepropeptide Rattus norvegicus 105-109 23537890-2 2013 Liver insult was induced by in vivo administration of D-galactosamine (d-GalN, 400 mg/kg, i.p.) Galactosamine 54-69 galanin and GMAP prepropeptide Rattus norvegicus 73-77 23375034-1 2013 OBJECTIVE: To unravel the mechanism of anti-inflammatory activity of carvacrol in D-galactosamine (D-GalN)-induced hepatotoxic rats. Galactosamine 82-97 galanin and GMAP prepropeptide Rattus norvegicus 101-105 21966103-1 2010 Objective of this study was to obtain a better understanding of the mechanism responsible for the d-galactosamine (d-GalN) induced hepatotoxicity and to study the effect of catechin against d-GalN induced hepatotoxicity. Galactosamine 98-113 galanin and GMAP prepropeptide Rattus norvegicus 117-121 21604090-1 2011 The present study aimed at investigating the effect of carvacrol on hepatic mitochondrial enzyme activities and DNA damage in D: -galactosamine (D: -GalN)-induced hepatotoxicity in male albino Wistar rats. Galactosamine 126-143 galanin and GMAP prepropeptide Rattus norvegicus 149-153 22280552-3 2012 D-Galactosamine (D-GalN), a hepatocyte-specific inhibitor of RNA synthesis, is known to sensitise animals to the lethal effects of LPS. Galactosamine 0-15 galanin and GMAP prepropeptide Rattus norvegicus 19-23 22738964-1 2012 We investigated in this study the effect of modified arabinoxylan from rice bran (MGN-3) and its fractions on D-galactosamine (D-GalN)-induced IL-18 expression and hepatitis in rats. Galactosamine 110-125 galanin and GMAP prepropeptide Rattus norvegicus 129-133 21550386-3 2011 Female Sprague-Dawley (SD) rats were intraperitoneally injected with a single dose of d-galactosamine (d-GalN, 1.4g/kg) to induce ALF. Galactosamine 86-101 galanin and GMAP prepropeptide Rattus norvegicus 105-109 19669999-5 2009 Peroxynitrite-mediated hepatic injury in rats was induced by administration of galactosamine/lipopolysaccharide (GalN/LPS). Galactosamine 79-92 galanin and GMAP prepropeptide Rattus norvegicus 113-117 20860438-2 2010 (Amaranthaceae) against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver injury in rats. Galactosamine 24-39 galanin and GMAP prepropeptide Rattus norvegicus 62-66 23105905-1 2010 To investigate Lecithin for its hepatoprotective activity against D-galactosamine (D-GalN) induced toxicity in freshly isolated rat hepatocytes and animal models. Galactosamine 66-81 galanin and GMAP prepropeptide Rattus norvegicus 85-89 19294511-3 2010 ALF was induced in rats by D-galactosamine (D-GalN). Galactosamine 27-42 galanin and GMAP prepropeptide Rattus norvegicus 46-50 20039932-0 2010 Pim-3 protects against hepatic failure in D-galactosamine (D-GalN)-sensitized rats. Galactosamine 42-57 galanin and GMAP prepropeptide Rattus norvegicus 61-65 19893024-1 2009 In galactosamine (GalN)-induced rat liver injury, hepatic stem/progenitor cells, small hepatocytes (SHs) and oval cells, transiently appear in the initial period of liver regeneration. Galactosamine 3-16 galanin and GMAP prepropeptide Rattus norvegicus 18-22 19650854-2 2009 This study was designed to investigate the hepatoprotective and antioxidant properties of carvacrol on D-galactosamine (D-GalN)-induced hepatotoxicity and oxidative damage in male albino Wistar rats. Galactosamine 103-118 galanin and GMAP prepropeptide Rattus norvegicus 122-126 19796704-1 2009 The goal of study was directed to investigate the effects of resveratrol (RES) pretreatment on the enhancing action of D-galactosamine (D-GalN; 800 mg/kg) on lipopolysaccharide (LPS; 0.5 microg/kg) inducing liver failure in rats. Galactosamine 119-134 galanin and GMAP prepropeptide Rattus norvegicus 138-142 18079613-2 2007 against D-galactosamine (D-GalN)-induced hepatopathy. Galactosamine 8-23 galanin and GMAP prepropeptide Rattus norvegicus 27-31 19601392-2 2009 The present study was designed to investigate the effect of carvacrol on D-galactosamine (D-GalN)-induced hepatotoxicity in rats. Galactosamine 73-88 galanin and GMAP prepropeptide Rattus norvegicus 92-96 17934810-0 2008 A role of cell apoptosis in lipopolysaccharide (LPS)-induced nonlethal liver injury in D-galactosamine (D-GalN)-sensitized rats. Galactosamine 87-102 galanin and GMAP prepropeptide Rattus norvegicus 106-110 17934810-1 2008 Lipopolysaccharide (LPS) is implicated in the pathology of acute liver injury and can induce lethal liver failure when simultaneously administered with D-galactosamine (D-GalN). Galactosamine 152-167 galanin and GMAP prepropeptide Rattus norvegicus 171-175 18756972-2 2008 METHODS: One hundred and sixty SD rats underwent intraperitoneal injection of D-galactosamine (D-GalN) 1.4 g/kg so as to establish AFL models and then were randomly divided into 2 equal groups: G-CSF therapy group, injected hypodermically with recombinant human G-CSF 50 microg x kg(-1) x d(-1) 2 hours after D-GalN injection for 3 consecutive days, and placebo control group, injected hypodermically with normal saline for 3 consecutive days. Galactosamine 78-93 galanin and GMAP prepropeptide Rattus norvegicus 97-101 20020892-1 2008 ABSTRACT Apoptotic markers and signals produced by xenobiotics as hepatotoxic D-galactosamine (D-GalN) and lipopolysaccharide (LPS) are extensively investigated in vivo. Galactosamine 78-93 galanin and GMAP prepropeptide Rattus norvegicus 97-101 18642107-1 2009 To elucidate the mechanism by which dietary amino acids suppress the D-galactosamine (D-GalN)-induced hepatitis, we examined the involvement of Kupffer cells, tumor necrosis factor-alpha (TNF-alpha) and apoptosis in the mechanism. Galactosamine 69-84 galanin and GMAP prepropeptide Rattus norvegicus 88-92 19317920-2 2009 The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial apoptosis- and proinflammatory cytokine-signaling pathways, and possible mechanism(s) by which green tea (GT) extract modulates the apoptotic and proinflammatory signaling in rat. Galactosamine 54-69 galanin and GMAP prepropeptide Rattus norvegicus 73-77 18634816-4 2008 When rats were treated with galactosamine/lipopolysaccharide (GalN/LPS), mtMGST1 activity was significantly increased, and the increased activity was reduced by the disulfide reducing agent dithiothreitol. Galactosamine 28-41 galanin and GMAP prepropeptide Rattus norvegicus 62-66 17616004-1 2007 D-Galactosamine (D-Galn: 300 mg/kg) was intraperitoneally administered to rats. Galactosamine 0-15 galanin and GMAP prepropeptide Rattus norvegicus 19-23 15610455-1 2005 BACKGROUND AND AIM: PGE1 reduces in vivo and in vitro D-galactosamine (D-GalN)-induced cell death in hepatocytes. Galactosamine 54-69 galanin and GMAP prepropeptide Rattus norvegicus 73-77 17064618-1 2006 OBJECTIVE: To investigate the situation of hepatocellular apoptosis in D-galactosamine (D-GalN)-sensitized rats with lipopolysaccharide (LPS)-induced acute liver failure and the mechanisms of liver injury therein. Galactosamine 71-86 galanin and GMAP prepropeptide Rattus norvegicus 90-94 16647638-1 2006 The pre-administration of PGE(1) reduced inducible nitric oxide synthase (NOS-2) expression and cell death induced by d-galactosamine (d-GalN) in cultured rat hepatocytes. Galactosamine 118-133 galanin and GMAP prepropeptide Rattus norvegicus 137-141 15565661-2 2004 We have previously shown that PGE1 preadministration protects against NO-dependent cell death induced by D-galactosamine (D-GalN) through a rapid increase of nuclear factor kappaB (NF-kappaB) activity, inducible NO synthase (NOS-2) expression, and NO production. Galactosamine 105-120 galanin and GMAP prepropeptide Rattus norvegicus 124-128 15189274-2 2004 Nitric oxide (NO) mediates PGE1 protection against D-galactosamine (D-GalN)-induced cell death. Galactosamine 51-66 galanin and GMAP prepropeptide Rattus norvegicus 70-74 14686721-5 2003 METHODS: Liver injury was induced in male Wistar rats by intraperitoneal injection of D-galactosamine (D-GalN) (1 g/kg). Galactosamine 86-101 galanin and GMAP prepropeptide Rattus norvegicus 105-109 12586601-1 2003 Tumour necrosis factor-alpha (TNF-alpha) mediates hepatocyte cell death by D-galactosamine (D-GalN) and its protection by prostaglandin E(1) (PGE(1)). Galactosamine 75-90 galanin and GMAP prepropeptide Rattus norvegicus 94-98 12907702-5 2003 AAF-fed rats were fully protected from the hepatotoxic effects of the injection of 20-30 microg of LPS plus 700 mg of d-galactosamine (d-GalN) x kg-1 of body weight, a treatment that in control rats readily caused a large increase of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling-positive cells in liver cryosections and release of alanine and aspartate aminotransferase into the bloodstream. Galactosamine 118-133 galanin and GMAP prepropeptide Rattus norvegicus 137-141 12580320-2 2003 The aim of the present study was to determine whether in vivo phosphorus-31 magnetic resonance spectroscopy (31P MRS) accurately assesses the severity of liver damage and is of prognostic value in a D-galactosamine (D-galN)-induced model of acute liver failure. Galactosamine 199-214 galanin and GMAP prepropeptide Rattus norvegicus 218-222 9525102-2 1998 Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D-GalN). Galactosamine 118-133 galanin and GMAP prepropeptide Rattus norvegicus 137-141 12236047-2 2002 In this study, the effect of D-galactosamine(GalN)-induced hepatitis on ethanol-induced gastric mucosal lesions and the protective effect of anti-ulcer agents in rats were examined. Galactosamine 29-44 galanin and GMAP prepropeptide Rattus norvegicus 45-49 10986217-2 2000 We have previously shown that protection against D-galactosamine (D-GalN) induced liver injury by prostaglandin E(1) (PGE(1)) was accompanied by an increase in TNF-alpha and nitrite/nitrate in serum. Galactosamine 49-64 galanin and GMAP prepropeptide Rattus norvegicus 68-72 12464973-2 2002 OBJECTIVES: Whether PGE1 protects against D-galactosamine (D-GalN)-associated hepatocyte cell death by the regulation of tumour necrosis factor-alpha (TNF-alpha) and/or nitric oxide (NO) in hepatocytes or cocultured Kupffer cells was examined. Galactosamine 42-57 galanin and GMAP prepropeptide Rattus norvegicus 61-65 11097840-1 2000 Hepatocyte growth factor (HGF) has a potent antiapoptotic effect on hepatocytes in D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-treated rats. Galactosamine 83-98 galanin and GMAP prepropeptide Rattus norvegicus 102-106 11360671-1 2000 AIM: To study the regulation of alpha 1-adrenoceptor on the biochemical changes involved in hepatocyte apoptosis induced by D-galactosamine (D-GalN) and lipopolysaccharide (LPS). Galactosamine 124-139 galanin and GMAP prepropeptide Rattus norvegicus 143-147 10758413-2 2000 PURPOSE: To investigate whether prevention of acute liver injury induced by D-galactosamine (D-GalN) with preadministration of PGE1 is correlated with a change in the concentration of two proinflammatory cytokines, as tumour necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1alpha, and/or nitrite+nitrate (NOx), as nitric oxide-related end products in serum. Galactosamine 76-91 galanin and GMAP prepropeptide Rattus norvegicus 95-99 1330797-2 1992 Acute liver injury was induced by a single administration of D-galactosamine (D-Galn) and lipopolysaccharide (LPS) or carbon tetrachloride (CCl4). Galactosamine 61-76 galanin and GMAP prepropeptide Rattus norvegicus 80-84 9219096-1 1997 The change of tryptophan-niacin metabolism in D-galactosamine (D-galN) injected rats was investigated. Galactosamine 46-61 galanin and GMAP prepropeptide Rattus norvegicus 65-69 9145214-4 1997 The methanol extract showed significant hepatoprotective activity against CCl4-toxicity in rats and D-galactosamine (D-GalN)/lipopolysaccharide-induced liver injury in mice. Galactosamine 100-115 galanin and GMAP prepropeptide Rattus norvegicus 119-123 7109714-4 1982 The amount of galactosamine-containing proteoglycosaminoglycans that are extractable with 4 M guanidinium chloride from cartilage is significantly higher in young rats (29.1 +/- 4.8 nmol GalN per mg cartilage wet weight) than in old animals (5.8 +/- 3.0 nmol GalN per mg cartilage wet weight). Galactosamine 14-27 galanin and GMAP prepropeptide Rattus norvegicus 187-191 2171727-1 1990 The present study was conducted to observe the effect of platelet activating factor antagonist-WEB 2086 on the galactosamine/endotoxin (GalN/E)-induced rat liver injury. Galactosamine 111-125 galanin and GMAP prepropeptide Rattus norvegicus 136-140 2965546-3 1988 The simultaneous presence of UDP-GalN, UDP-GalNAc, UDP-GlcN, and UDP-GlcNAc in concentrations resembling their overall content in livers 6 h after D-galactosamine administration led to an inhibition of the glycolipid galactosyltransferases, GL2 and GM1 synthases of 44 and 64%, respectively. Galactosamine 147-162 galanin and GMAP prepropeptide Rattus norvegicus 33-37 7109714-4 1982 The amount of galactosamine-containing proteoglycosaminoglycans that are extractable with 4 M guanidinium chloride from cartilage is significantly higher in young rats (29.1 +/- 4.8 nmol GalN per mg cartilage wet weight) than in old animals (5.8 +/- 3.0 nmol GalN per mg cartilage wet weight). Galactosamine 14-27 galanin and GMAP prepropeptide Rattus norvegicus 259-263 33107697-1 2021 d-Galactosamine (d-GalN) is a well-known toxin that causes many metabolic and morphological abnormalities resulting in advanced renal failure and liver damage. Galactosamine 0-15 galanin and GMAP prepropeptide Rattus norvegicus 19-23