PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33566377-5	2021	Whereas GalN/LPS treatment-induced hepatic activation of NF-kappaB and JNK in wild-type and SphK2-/- mice, these signaling pathways were reduced in SphK1-/- mice.	Galactosamine	8-12	mitogen-activated protein kinase 8	Mus musculus	71-74	
17300814-3	2007	The aim of this study is to assess the role of JNK during D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury, an experimental model of FHF, using SP600125, a small molecule JNK-specific inhibitor.	Galactosamine	58-73	mitogen-activated protein kinase 8	Mus musculus	47-50	
28661486-2	2017	ROS production from mitochondria activates MAP3 kinases, such as MLK3 and ASK1, which continue to activate a pathway to sustain JNK activation, and amplifies the toxic effect of acetaminophen (APAP) and TNF/galactosamine (TNF/GalN).	Galactosamine	207-220	mitogen-activated protein kinase 8	Mus musculus	128-131	
28661486-2	2017	ROS production from mitochondria activates MAP3 kinases, such as MLK3 and ASK1, which continue to activate a pathway to sustain JNK activation, and amplifies the toxic effect of acetaminophen (APAP) and TNF/galactosamine (TNF/GalN).	Galactosamine	226-230	mitogen-activated protein kinase 8	Mus musculus	128-131	
26459629-0	2015	Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.	Galactosamine	46-61	mitogen-activated protein kinase 8	Mus musculus	118-121	
23758073-9	2014	Finally, administration of sodium thiosulfate (STS) attenuated GalN/LPS-induced liver injury via activation of Akt- and Nrf2-dependent signaling and inhibition of GalN/LPS-induced JNK phosphorylation in WT mice.	Galactosamine	163-167	mitogen-activated protein kinase 8	Mus musculus	180-183	
21985290-0	2011	Echinacea alkamides prevent lipopolysaccharide/D-galactosamine-induced acute hepatic injury through JNK pathway-mediated HO-1 expression.	Galactosamine	47-62	mitogen-activated protein kinase 8	Mus musculus	100-103	
18772342-2	2008	We investigated the mechanism of both apoptotic and necrotic hepatocyte cell death as well as the role of c-Jun NH2-terminal kinase (JNK) in the ConA and ConA/D-galactosamine (GalN) models of murine liver injury.	Galactosamine	176-180	mitogen-activated protein kinase 8	Mus musculus	106-131	
19997066-5	2010	LPS/GalN-mediated phosphorylation of JNK1/2 and ERK1/2 was differentially regulated in wild-type and PXR-null mice.	Galactosamine	4-8	mitogen-activated protein kinase 8	Mus musculus	37-43	
19119023-5	2009	However, combined loss of Bid and another BH3-only protein, Bim, activated by c-Jun N-terminal kinase (JNK), protected mice from LPS+GalN-induced hepatitis.	Galactosamine	133-137	mitogen-activated protein kinase 8	Mus musculus	103-106	
17300814-3	2007	The aim of this study is to assess the role of JNK during D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury, an experimental model of FHF, using SP600125, a small molecule JNK-specific inhibitor.	Galactosamine	75-79	mitogen-activated protein kinase 8	Mus musculus	47-50	
17300814-5	2007	GalN/LPS treatment induced sustained JNK activation.	Galactosamine	0-4	mitogen-activated protein kinase 8	Mus musculus	37-40	
17300814-9	2007	These results confirm the role of JNK as a critical apoptotic mediator in GalN/LPS-induced FHF.	Galactosamine	74-78	mitogen-activated protein kinase 8	Mus musculus	34-37