PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9657319-3	1998	The expression of other constitutive type heat shock proteins, namely HSP60, HSP32 and HSP25 was also reduced in mice injected with D-galactosamine and lipopolysaccharide.	Galactosamine	132-147	heme oxygenase 1	Mus musculus	77-82	
14512878-3	2003	We found that up-regulation of endogenous HO-1 by cobalt-protoporphyrin-IX (CoPP) protected mice from apoptotic liver damage induced by anti-CD95 antibody (Ab) or d-galactosamine in combination with either anti-CD3 Ab, lipopolysaccharide (LPS), or tumor necrosis factor alpha (TNF-alpha).	Galactosamine	163-178	heme oxygenase 1	Mus musculus	42-46	
9500698-3	1998	To investigate the hepatic cellular source of the increased HO-1 transcript, we treated mice with LPS and galactosamine (700 mg/kg, intraperitoneally), a selective transcriptional inhibitor of hepatocytes.	Galactosamine	106-119	heme oxygenase 1	Mus musculus	60-64	
9500698-4	1998	Galactosamine prevented the LPS-mediated increase of HO-1 mRNA in the liver, indicating that hepatocytes are the main cell type in which HO-1 mRNA accumulates after LPS treatment.	Galactosamine	0-13	heme oxygenase 1	Mus musculus	53-57	
9500698-4	1998	Galactosamine prevented the LPS-mediated increase of HO-1 mRNA in the liver, indicating that hepatocytes are the main cell type in which HO-1 mRNA accumulates after LPS treatment.	Galactosamine	0-13	heme oxygenase 1	Mus musculus	137-141	
30597292-0	2019	Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-kappaB and activating Nrf2/HO-1 signaling pathways.	Galactosamine	54-69	heme oxygenase 1	Mus musculus	147-151	
30641432-3	2019	After lipopolysaccharide (LPS)/d-galactosamine (d-GalN) administration, five flavonoids inhibited oxidative activities with reducing nitric oxide synthase (iNOS), malondialdehyde (MDA), and improving catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (T-AOC), nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	Galactosamine	31-46	heme oxygenase 1	Mus musculus	343-359	
28213269-0	2017	Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-kappaB and activating Nrf2/HO-1 signaling pathways.	Galactosamine	50-65	heme oxygenase 1	Mus musculus	142-146	
29715757-0	2018	Madecassoside prevents acute liver failure in LPS/D-GalN-induced mice by inhibiting p38/NF-kappaB and activating Nrf2/HO-1 signaling.	Galactosamine	50-56	heme oxygenase 1	Mus musculus	118-122	
23994575-6	2013	HO-1 induction with hemin reversed the lethality induced by GalN/LPS administration, and ZnPP pretreatment blocked this change.	Galactosamine	60-64	heme oxygenase 1	Mus musculus	0-4	
25311666-7	2014	In addition, linalool increased Nrf2 and heme oxygenase-1 expression up-regulation by LPS/GalN.	Galactosamine	90-94	heme oxygenase 1	Mus musculus	41-57	
23994575-16	2013	Furthermore, HO-1 overexpression may protect the liver against GalN/LPS-induced inflammation through suppression of the NLRP3 signaling pathway.	Galactosamine	63-67	heme oxygenase 1	Mus musculus	13-17	
21985290-0	2011	Echinacea alkamides prevent lipopolysaccharide/D-galactosamine-induced acute hepatic injury through JNK pathway-mediated HO-1 expression.	Galactosamine	47-62	heme oxygenase 1	Mus musculus	121-125	
19997066-7	2010	Expression levels of pro-survival proteins Bcl-xL and heme oxygenase-1 (HO-1), which are downstream of Stat3, were substantially lower in PXR-null than wild-type mouse livers after LPS/GalN treatment.	Galactosamine	185-189	heme oxygenase 1	Mus musculus	54-70	
21843953-6	2011	Moreover, IL-22 treatment significantly enhanced activation of STAT3 and up-regulated the expression of Bcl-xL, heme oxygenase-1 (HO-1) and redox factor-1 (Ref-1) in the liver injury induced by GalN/LPS.	Galactosamine	194-198	heme oxygenase 1	Mus musculus	112-128	
18420187-0	2008	Protective effect of baicalin against lipopolysaccharide/D-galactosamine-induced liver injury in mice by up-regulation of heme oxygenase-1.	Galactosamine	57-72	heme oxygenase 1	Mus musculus	122-138