PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15529623-9	2004	Two of the three insulin resistant children had positive GADA and one of them had positive ICA, therefore showing "mixed" features of both type 1 (autoimmunity) and type 2 diabetes (insulin resistance).	ica	91-94	insulin	Homo sapiens	17-24	
10229311-9	1999	During follow-up, a decrease in ICA titres was observed in the group which received prophylactic insulin in contrast with the untreated group.	ica	32-35	insulin	Homo sapiens	97-104	
9357409-9	1997	94% of patients with ICA and 84% of those with GADA required insulin therapy by 6 years, compared with 14% of those without the antibodies (p < 0.0001).	ica	21-24	insulin	Homo sapiens	61-68	
1954807-5	1991	RESULTS: At the first test, insulin responses correlated with age in ICA- children less than or equal to 11 yr old (r = 0.46, p less than 0.001).	ica	69-72	insulin	Homo sapiens	28-35	
7657024-8	1995	Insulin autoantibodies (IAAs) were found in 3.4 and 15.4% of ICA+ children and first-degree relatives, respectively.	ica	61-64	insulin	Homo sapiens	0-7	
1954807-9	1991	At subsequent tests, ICA+ and ICA- subjects displayed distinct changes; the mean +/- SE insulin response increased in ICA- subjects from 619.2 +/- 40.8 to 716.4 +/- 50.4 pM (P less than 0.001) but declined in ICA+ subjects from 403.2 +/- 91.8 to 313.8 +/- 67.2 pM (P less than 0.02).	ica	21-24	insulin	Homo sapiens	88-95	
1954807-9	1991	At subsequent tests, ICA+ and ICA- subjects displayed distinct changes; the mean +/- SE insulin response increased in ICA- subjects from 619.2 +/- 40.8 to 716.4 +/- 50.4 pM (P less than 0.001) but declined in ICA+ subjects from 403.2 +/- 91.8 to 313.8 +/- 67.2 pM (P less than 0.02).	ica	30-33	insulin	Homo sapiens	88-95	
1954807-9	1991	At subsequent tests, ICA+ and ICA- subjects displayed distinct changes; the mean +/- SE insulin response increased in ICA- subjects from 619.2 +/- 40.8 to 716.4 +/- 50.4 pM (P less than 0.001) but declined in ICA+ subjects from 403.2 +/- 91.8 to 313.8 +/- 67.2 pM (P less than 0.02).	ica	30-33	insulin	Homo sapiens	88-95	
1954807-9	1991	At subsequent tests, ICA+ and ICA- subjects displayed distinct changes; the mean +/- SE insulin response increased in ICA- subjects from 619.2 +/- 40.8 to 716.4 +/- 50.4 pM (P less than 0.001) but declined in ICA+ subjects from 403.2 +/- 91.8 to 313.8 +/- 67.2 pM (P less than 0.02).	ica	30-33	insulin	Homo sapiens	88-95	
1910427-5	1991	Insulin autoantibodies were found in 86.9% of healthy ICA-positive sibs.	ica	54-57	insulin	Homo sapiens	0-7	
3525287-6	1986	In an ongoing study of beta-cell function in ICA-positive nondiabetic individuals, the additional presence of insulin autoantibodies significantly increased the likelihood of beta-cell dysfunction.	ica	45-48	insulin	Homo sapiens	110-117	
3525287-7	1986	After intravenous glucose stimulation, insulinopenia was present in 70% of ICA and insulin-autoantibody-positive individuals in contrast to only 23% of ICA-positive, insulin-autoantibody-negative persons.	ica	75-78	insulin	Homo sapiens	39-46	
769892-5	1976	Repeat ICA testing in five pair of insulin-dependent twins and in the siblings of one pair showed that ICAs may be present in people with normal glucose tolerance" may precede clinical diabetes by several years; and may decline in titre or disappear with increasing duration of disease.	ica	7-10	insulin	Homo sapiens	35-42