PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11325898-6	2001	Reactivity of GAD65 antibody- and IA2 antibody-positive sera from patients newly diagnosed with insulin-dependent diabetes mellitus, from ICA-positive prediabetics, and from ICA-positive first-degree relatives demonstrated conservation of the relevant autoreactive epitopes.	ica	138-141	glutamate decarboxylase 2	Homo sapiens	14-19	
11325898-6	2001	Reactivity of GAD65 antibody- and IA2 antibody-positive sera from patients newly diagnosed with insulin-dependent diabetes mellitus, from ICA-positive prediabetics, and from ICA-positive first-degree relatives demonstrated conservation of the relevant autoreactive epitopes.	ica	174-177	glutamate decarboxylase 2	Homo sapiens	14-19	
8423231-2	1993	However, we now report that preabsorption of ICA-positive sera with recombinant glutamate decarboxylase (human GAD 65 and/or GAD 67) reduced or blocked the ICA reactivity of 5/18 (27%) new-onset IDD patients and 7/18 (39%) prediabetics.	ica	45-48	glutamate decarboxylase 2	Homo sapiens	111-117	
8943434-2	1996	Human monoclonal ICA (MICA 1-6), previously derived from a DR1/DR7-positive newly diagnosed diabetic patient, recognized the islet cell autoantigen glutamate decarboxylase 65 (GAD65) and defined two distinct conformational (MICA 1/3 and MICA 4/6) and one linear (MICA 2) autoimmune epitopes in this molecule.	ica	17-20	glutamate decarboxylase 2	Homo sapiens	148-174	
8943434-2	1996	Human monoclonal ICA (MICA 1-6), previously derived from a DR1/DR7-positive newly diagnosed diabetic patient, recognized the islet cell autoantigen glutamate decarboxylase 65 (GAD65) and defined two distinct conformational (MICA 1/3 and MICA 4/6) and one linear (MICA 2) autoimmune epitopes in this molecule.	ica	17-20	glutamate decarboxylase 2	Homo sapiens	176-181	
9075795-4	1997	Combined analysis of GAD65-A and IA2c-A detected 93-100% of the ICA+ sera, and, at equal specificity, improved the diagnostic sensitivity (85%) for IDDM compared with that of ICA (74%).	ica	64-67	glutamate decarboxylase 2	Homo sapiens	21-26	
9075795-10	1997	In sum, GAD65-A and IA2c-A detected much ICA reactivity, and their combined evaluation and detection is suitable to replace the histochemical ICA test.	ica	41-44	glutamate decarboxylase 2	Homo sapiens	8-13	
9028724-17	1997	Our data also indicate that other autoantibodies than IA-2-Ab, GAD65-Ab and IAA contribute to ICA.	ica	94-97	glutamate decarboxylase 2	Homo sapiens	63-68	
8039604-5	1994	In contrast, all restricted ICA sera (n = 6) had both GAD65 and GAD67 autoantibodies.	ica	28-31	glutamate decarboxylase 2	Homo sapiens	54-59	
8039604-7	1994	The titer of GAD65 autoantibodies was much higher in the restricted ICA sera (titer > 1:1,000) than in the sera from individuals with new-onset diabetes or prediabetes (titer < 1:100) and was reflected by the greater amount of GAD65 protein immunoprecipitated by restricted ICA sera (2.61 +/- 1.39 U) compared with sera from individuals with new-onset diabetes (0.51 +/- 0.34 U).	ica	68-71	glutamate decarboxylase 2	Homo sapiens	13-18	
8039604-7	1994	The titer of GAD65 autoantibodies was much higher in the restricted ICA sera (titer > 1:1,000) than in the sera from individuals with new-onset diabetes or prediabetes (titer < 1:100) and was reflected by the greater amount of GAD65 protein immunoprecipitated by restricted ICA sera (2.61 +/- 1.39 U) compared with sera from individuals with new-onset diabetes (0.51 +/- 0.34 U).	ica	280-283	glutamate decarboxylase 2	Homo sapiens	13-18	
8039604-8	1994	The restricted ICA sera immunoprecipitated equimolar amounts of GAD65 protein fragments, suggesting a non-conformational or linear epitope; epitope mapping localized the major epitope region to amino acids 361-442 and a second minor epitope region to amino acids 1-195.	ica	15-18	glutamate decarboxylase 2	Homo sapiens	64-69	
8423231-2	1993	However, we now report that preabsorption of ICA-positive sera with recombinant glutamate decarboxylase (human GAD 65 and/or GAD 67) reduced or blocked the ICA reactivity of 5/18 (27%) new-onset IDD patients and 7/18 (39%) prediabetics.	ica	156-159	glutamate decarboxylase 2	Homo sapiens	111-117	
8423231-4	1993	ICA reactivity to GAD was not related to serum ICA titer nor the age of the individual, and in all cases tested was blocked by GAD 65 or GAD 67 with equivalent efficiency.	ica	0-3	glutamate decarboxylase 2	Homo sapiens	127-133