PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20213084-0 2010 The pan-DAC inhibitor LBH589 is a multi-functional agent in breast cancer cells: cytotoxic drug and inducer of sodium-iodide symporter (NIS). Nickel 136-139 arylacetamide deacetylase Homo sapiens 8-11 23914598-10 2013 Scientific evidence now agree that nickel and certain nickel compounds are toxic and highly harmful to human health they indeed cause allergic contact dermatitis (DAC). Nickel 35-41 arylacetamide deacetylase Homo sapiens 163-166 23914598-10 2013 Scientific evidence now agree that nickel and certain nickel compounds are toxic and highly harmful to human health they indeed cause allergic contact dermatitis (DAC). Nickel 54-60 arylacetamide deacetylase Homo sapiens 163-166 20213084-4 2010 In the present study, we report for the first time that the pan-deacetylase (DAC) inhibitor LBH589 (panobinostat) significantly induced NIS, both as mRNA and as protein, through the increase of NIS promoter activity, with the final consequence of obtaining a significant up-take of iodide in MCF7, T47D, and MDA-MB231 breast cancer cells. Nickel 136-139 arylacetamide deacetylase Homo sapiens 77-80 20213084-4 2010 In the present study, we report for the first time that the pan-deacetylase (DAC) inhibitor LBH589 (panobinostat) significantly induced NIS, both as mRNA and as protein, through the increase of NIS promoter activity, with the final consequence of obtaining a significant up-take of iodide in MCF7, T47D, and MDA-MB231 breast cancer cells. Nickel 194-197 arylacetamide deacetylase Homo sapiens 77-80