PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24673390-0 2014 The nickel dose-response relationship by filaggrin genotype (FLG). Nickel 4-10 filaggrin Homo sapiens 41-50 24673390-0 2014 The nickel dose-response relationship by filaggrin genotype (FLG). Nickel 4-10 filaggrin Homo sapiens 61-64 24673390-2 2014 One probable contributor is filaggrin, which binds nickel avidly. Nickel 51-57 filaggrin Homo sapiens 28-37 24673390-3 2014 Filaggrin gene (FLG) null mutations lead to a complete lack of filaggrin production from the affected allele, and have been associated with an increased risk of nickel contact sensitization in German and Danish adults. Nickel 161-167 filaggrin Homo sapiens 0-9 24673390-3 2014 Filaggrin gene (FLG) null mutations lead to a complete lack of filaggrin production from the affected allele, and have been associated with an increased risk of nickel contact sensitization in German and Danish adults. Nickel 161-167 filaggrin Homo sapiens 16-19 24157460-0 2014 Filaggrin is a predominant member of the denaturation-resistant nickel-binding proteome of human epidermis. Nickel 64-70 filaggrin Homo sapiens 0-9 23343419-1 2013 BACKGROUND: Although heterozygous filaggrin gene (FLG) mutation carriers seem to have an increased risk of atopic, irritant and allergic nickel dermatitis, it remains unclear whether the risk of contact sensitization to allergens other than nickel is also elevated in FLG mutation carriers. Nickel 137-143 filaggrin Homo sapiens 34-43 23343419-1 2013 BACKGROUND: Although heterozygous filaggrin gene (FLG) mutation carriers seem to have an increased risk of atopic, irritant and allergic nickel dermatitis, it remains unclear whether the risk of contact sensitization to allergens other than nickel is also elevated in FLG mutation carriers. Nickel 137-143 filaggrin Homo sapiens 50-53 23343419-6 2013 CONCLUSION: FLG mutation carriers with self-reported dermatitis have an increased risk of contact sensitization to substances other than nickel, whereas FLG mutations alone may not, or may only slightly, increase the risk of sensitization. Nickel 137-143 filaggrin Homo sapiens 12-15 21909780-7 2011 A more recent study revealed an association between FLG mutations and increased nickel sensitization, but not other contact allergens. Nickel 80-86 filaggrin Homo sapiens 52-55 35359602-1 2022 Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel. Nickel 174-180 filaggrin Homo sapiens 53-62 20346018-0 2010 The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. Nickel 90-96 filaggrin Homo sapiens 46-55 20346018-1 2010 BACKGROUND: It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. Nickel 106-112 filaggrin Homo sapiens 39-48 20346018-1 2010 BACKGROUND: It was recently shown that filaggrin gene (FLG) null mutations are positively associated with nickel sensitization. Nickel 106-112 filaggrin Homo sapiens 55-58 20346018-2 2010 We have hypothesized that histidine-rich filaggrin proteins in the epidermis chelate nickel ions and prevent their skin penetration and exposure to Langerhans cells. Nickel 85-91 filaggrin Homo sapiens 41-50 20346018-3 2010 Furthermore, we have proposed that the low degree of genetic predisposition to nickel sensitization found by a Danish twin study was explained by a high prevalence of ear piercing among participants resulting in "bypassing" of the filaggrin proteins. Nickel 79-85 filaggrin Homo sapiens 231-240 20346018-4 2010 OBJECTIVES: To investigate the association between FLG null mutations and (nickel) contact sensitization. Nickel 75-81 filaggrin Homo sapiens 51-54 20346018-8 2010 A crude analysis on women who did not have ear piercings revealed a positive association between FLG null mutations and nickel sensitization [8 3% vs. 2 4%; odds ratio (OR) 3 71, 95% confidence interval (CI) 0 73-18 96] as well as between FLG null mutations and allergic nickel dermatitis (8 3% vs. 1 3%; OR 6 75, 95% CI 1 17-38 91). Nickel 120-126 filaggrin Homo sapiens 97-100 20346018-8 2010 A crude analysis on women who did not have ear piercings revealed a positive association between FLG null mutations and nickel sensitization [8 3% vs. 2 4%; odds ratio (OR) 3 71, 95% confidence interval (CI) 0 73-18 96] as well as between FLG null mutations and allergic nickel dermatitis (8 3% vs. 1 3%; OR 6 75, 95% CI 1 17-38 91). Nickel 120-126 filaggrin Homo sapiens 239-242 20346018-10 2010 CONCLUSIONS: This study suggests that FLG null mutations may be a risk factor for the development of nickel sensitization. Nickel 101-107 filaggrin Homo sapiens 38-41 19134432-0 2008 Nickel sensitization, hand eczema, and loss-of-function mutations in the filaggrin gene. Nickel 0-6 filaggrin Homo sapiens 73-82 19134432-3 2008 This unique finding may have great implications for our understanding of nickel sensitization because nickel is chelated in the epidermis and perhaps to FLG. Nickel 73-79 filaggrin Homo sapiens 153-156 19134432-3 2008 This unique finding may have great implications for our understanding of nickel sensitization because nickel is chelated in the epidermis and perhaps to FLG. Nickel 102-108 filaggrin Homo sapiens 153-156 19134432-5 2008 The new knowledge concerning loss-of-function mutations in the FLG gene (the lack of specific nickel-chelating power in the stratum corneum and a generally defective skin barrier) suggests that an additive effect from irritants and nickel may aggravate hand eczema in individuals with loss-of-function mutations in the FLG gene. Nickel 94-100 filaggrin Homo sapiens 63-66 19134432-5 2008 The new knowledge concerning loss-of-function mutations in the FLG gene (the lack of specific nickel-chelating power in the stratum corneum and a generally defective skin barrier) suggests that an additive effect from irritants and nickel may aggravate hand eczema in individuals with loss-of-function mutations in the FLG gene. Nickel 232-238 filaggrin Homo sapiens 63-66 19134432-5 2008 The new knowledge concerning loss-of-function mutations in the FLG gene (the lack of specific nickel-chelating power in the stratum corneum and a generally defective skin barrier) suggests that an additive effect from irritants and nickel may aggravate hand eczema in individuals with loss-of-function mutations in the FLG gene. Nickel 232-238 filaggrin Homo sapiens 319-322 21166815-0 2011 Nickel reactivity and filaggrin null mutations--evaluation of the filaggrin bypass theory in a general population. Nickel 0-6 filaggrin Homo sapiens 66-75 21166815-1 2011 BACKGROUND: It was recently shown that filaggrin null mutation carrier status was associated with nickel allergy and self-reported intolerance to costume jewellery. Nickel 98-104 filaggrin Homo sapiens 39-48 21166815-2 2011 Because of the biochemical characteristics of filaggrin, it may show nickel barrier properties in the stratum corneum. Nickel 69-75 filaggrin Homo sapiens 46-55 21166815-3 2011 OBJECTIVES: To investigate whether subjects with filaggrin null mutations report nickel dermatitis at an earlier age than wild-type individuals, and to analyse whether null mutation carriers have stronger patch test reactivity to nickel sulfate than do wild-type individuals. Nickel 81-87 filaggrin Homo sapiens 49-58 21166815-5 2011 RESULTS: The mean number of years at risk of developing nickel dermatitis was significantly lower for the filaggrin null genotype than for the wild-type genotype when ear piercing status was considered. Nickel 56-62 filaggrin Homo sapiens 106-115 21166815-7 2011 CONCLUSIONS: Filaggrin null mutations may lower the age of onset of nickel dermatitis. Nickel 68-74 filaggrin Homo sapiens 13-22 21166815-8 2011 The hypothesis that ear piercings obscure the effect of filaggrin null mutations on the development of nickel allergy in statistical analyses was supported. Nickel 103-109 filaggrin Homo sapiens 56-65 19831422-3 2010 Metal allergy is mainly an environmental disorder although null mutations in the filaggrin gene complex were recently found to be associated with nickel allergy and dermatitis. Nickel 146-152 filaggrin Homo sapiens 81-90 18049447-0 2008 Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. Nickel 87-93 filaggrin Homo sapiens 34-43 35474514-0 2022 Nickel penetration into stratum corneum in FLG null carriers-A human experimental study. Nickel 0-6 filaggrin Homo sapiens 43-46 35474514-3 2022 OBJECTIVES: To elucidate the association between FLG status and nickel penetration into stratum corneum (SC) in individuals without self-reported history of nickel allergy. Nickel 64-70 filaggrin Homo sapiens 49-52 35474514-10 2022 CONCLUSION: FLG null carriers had less nickel recovered by tape strips compared with FLG wt carriers and, compared with individuals without a history of skin and/or respiratory symptoms, indicating higher nickel penetration into SC for FLG null carriers, but further studies are needed. Nickel 39-45 filaggrin Homo sapiens 12-15 35474514-10 2022 CONCLUSION: FLG null carriers had less nickel recovered by tape strips compared with FLG wt carriers and, compared with individuals without a history of skin and/or respiratory symptoms, indicating higher nickel penetration into SC for FLG null carriers, but further studies are needed. Nickel 205-211 filaggrin Homo sapiens 12-15 35474514-10 2022 CONCLUSION: FLG null carriers had less nickel recovered by tape strips compared with FLG wt carriers and, compared with individuals without a history of skin and/or respiratory symptoms, indicating higher nickel penetration into SC for FLG null carriers, but further studies are needed. Nickel 205-211 filaggrin Homo sapiens 236-239 35359602-1 2022 Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel. Nickel 174-180 filaggrin Homo sapiens 64-67 35359602-4 2022 The goal of the study was to analyse the distribution of such cleavable motifs in the human proteome and examine FLG vulnerability of nickel hydrolysis. Nickel 134-140 filaggrin Homo sapiens 113-116 35359602-11 2022 Ni2+-assisted cleavage of barrier proteins, including FLG, may contribute to clinical disease associated with nickel exposure. Nickel 110-116 filaggrin Homo sapiens 54-57