PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14729612-6	2004	Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds.	Nickel	317-323	thymoma viral proto-oncogene 1	Mus musculus	56-59	
14729612-0	2004	Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells.	Nickel	0-6	thymoma viral proto-oncogene 1	Mus musculus	59-62	
14729612-5	2004	Inhibition of PI-3K, Akt, and p70(S6k) by overexpression of a dominant-negative mutant of PI-3K (Deltap85) impaired nickel-induced HIF-1 transactivation.	Nickel	116-122	thymoma viral proto-oncogene 1	Mus musculus	21-24	
14729612-6	2004	Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds.	Nickel	93-99	thymoma viral proto-oncogene 1	Mus musculus	56-59	
14729612-6	2004	Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds.	Nickel	93-99	thymoma viral proto-oncogene 1	Mus musculus	68-71	
14729612-6	2004	Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds.	Nickel	93-99	thymoma viral proto-oncogene 1	Mus musculus	68-71	
32402875-0	2020	Effect and mechanism of PI3K/AKT/mTOR signaling pathway in the apoptosis of GC-1 cells induced by nickel nanoparticles.	Nickel	98-104	thymoma viral proto-oncogene 1	Mus musculus	29-32	
23317420-0	2013	Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway.	Nickel	37-43	thymoma viral proto-oncogene 1	Mus musculus	99-102	
23317420-10	2013	Sesamin increased expression levels of phosphoinositide-3-kinase (PI3K) and phosphorylated protein kinase B (PBK/Akt) in liver, which in turn inactivated pro-apoptotic signaling events, restoring the balance between pro- and anti-apoptotic Bcl-2 proteins in the liver of nickel-treated mice.	Nickel	271-277	thymoma viral proto-oncogene 1	Mus musculus	113-116	
23317420-11	2013	In conclusion, these results suggested that the inhibition of nickel-induced apoptosis by sesamin is due at least in part to its antioxidant activity and its ability to modulate the PI3K-Akt signaling pathway.	Nickel	62-68	thymoma viral proto-oncogene 1	Mus musculus	187-190	
14729612-6	2004	Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds.	Nickel	317-323	thymoma viral proto-oncogene 1	Mus musculus	68-71	
14729612-6	2004	Furthermore, an overexpression of the dominant-negative Akt mutant (Akt-T308A/S473A) blocked nickel-induced Akt phosphorylation and HIF-1 transactivation, whereas inhibition of p70(S6k) activation by pretreatment of cells with rapamycin did not show significant inhibitory effects on HIF-1 transactivation induced by nickel compounds.	Nickel	317-323	thymoma viral proto-oncogene 1	Mus musculus	68-71	
14729612-7	2004	Consistent with HIF-1 transactivation, inhibition of the PI-3K/Akt pathway by either overexpression of Deltap85 or Akt-T308A/S473A caused dramatic inhibition of Cap43 protein expression induced by nickel compounds, whereas pretreatment of cells with rapamycin did not exhibit inhibition of Cap43 induction.	Nickel	197-203	thymoma viral proto-oncogene 1	Mus musculus	115-118	
14729612-8	2004	These results demonstrated that nickel compounds induce HIF-1 transactivation and Cap43 protein expression through a PI-3K/Akt-dependent and p70(S6k)-independent pathway.	Nickel	32-38	thymoma viral proto-oncogene 1	Mus musculus	123-126	
34352574-0	2021	Nickel induces autophagy via PI3K/AKT/mTOR and AMPK pathways in mouse kidney.	Nickel	0-6	thymoma viral proto-oncogene 1	Mus musculus	34-37