PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24448832-3	2014	Here, we investigated the role of ABCB1 in nickel-induced stress signaling mediated by reactive oxygen species (ROS) and ceramides.	Nickel	43-49	ATP binding cassette subfamily B member 1	Canis lupus familiaris	34-39	
24448832-0	2014	Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1.	Nickel	0-6	ATP binding cassette subfamily B member 1	Canis lupus familiaris	136-141	
24448832-6	2014	ABCB1 protects against nickel toxicity as PSC833, an ABCB1 blocker, augmented the decrease in cell viability by nickel.	Nickel	23-29	ATP binding cassette subfamily B member 1	Canis lupus familiaris	0-5	
24448832-6	2014	ABCB1 protects against nickel toxicity as PSC833, an ABCB1 blocker, augmented the decrease in cell viability by nickel.	Nickel	112-118	ATP binding cassette subfamily B member 1	Canis lupus familiaris	0-5	
24448832-6	2014	ABCB1 protects against nickel toxicity as PSC833, an ABCB1 blocker, augmented the decrease in cell viability by nickel.	Nickel	112-118	ATP binding cassette subfamily B member 1	Canis lupus familiaris	53-58	
24448832-7	2014	Moreover, nickel toxicity was attenuated in renal MDCK cells stably overexpressing ABCB1.	Nickel	10-16	ATP binding cassette subfamily B member 1	Canis lupus familiaris	83-88	
24448832-12	2014	In conclusion, nickel induces a ROS-ceramide pathway to cause apoptotic cell death as well as activate adaptive survival responses, including upregulation of ABCB1, which improves cell survival by extruding proapoptotic (glucosyl)ceramides.	Nickel	15-21	ATP binding cassette subfamily B member 1	Canis lupus familiaris	158-163