PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29524267-0	2018	Cytokine patterns in vitro, in particular IL-5/IL-8 ratio, to detect patients with nickel contact allergy.	Nickel	83-89	interleukin 5	Homo sapiens	42-46	
7671317-2	1995	Nickel-reactive T cells described so far display a TH1 lymphokine secretion pattern characterized by high amounts of IFN gamma, but little or no IL-4 and IL-5.	Nickel	0-6	interleukin 5	Homo sapiens	154-158	
7671317-5	1995	These TCC responded to nickel with the production of high levels of IL-5 and variable amounts of IFN-gamma and IL-4 resembling TH2- or TH0-like cytokine secretion pattern.	Nickel	23-29	interleukin 5	Homo sapiens	68-72	
18569071-8	2008	The low IL-5 response to TT was associated with a higher induction of the down-regulatory cytokine IL-10 by TT as compared to nickel (p < 0.001).	Nickel	126-132	interleukin 5	Homo sapiens	8-12	
17642139-13	2006	There was an increase in the production of IFNgamma and IL-5 after NiSO4 stimulation in patients with systemic allergy to nickel.	Nickel	122-128	interleukin 5	Homo sapiens	56-60	
17642139-16	2006	SUMMARY: IFNgamma plays an essential role in the mechanism of developing of contact allergy to nickel; and IFNgamma as well as IL-5 play a role in the mechanism of developing systemic allergy to nickel.	Nickel	195-201	interleukin 5	Homo sapiens	127-131	
15347381-12	2004	CONCLUSIONS: These results indicate that measuring both T cell proliferation and cytokine secretion profiles, in particular IL-5 release using IL-4/IL-7 supplemented medium, offers a promising improvement of the in vitro diagnostic options in monitoring nickel contact sensitization.	Nickel	254-260	interleukin 5	Homo sapiens	124-128	
12207582-9	2002	Using the ELISpot assay, we found that PBMC from nickel-allergic individuals responded to Ni2+ with significantly greater production of interleukin (IL)-4, IL-5, IL-13 and interferon-gamma, but not IL-12, compared with the healthy controls.	Nickel	49-55	interleukin 5	Homo sapiens	156-160	
10651989-3	2000	Here, we examined the properties of a subset of nickel-specific CD4+ T cells displaying the cytokine profile (IL-10 , IL-5 , IFN-gamma+/-, IL-4+/-) of T regulatory cells 1 (Tr1) and with the potential to down-modulate immune responses to nickel.	Nickel	48-54	interleukin 5	Homo sapiens	118-122	
19572476-0	2009	Contact allergy to nickel: patch test score correlates with IL-5, but not with IFN-gamma nickel-specific secretion by peripheral blood lymphocytes.	Nickel	19-25	interleukin 5	Homo sapiens	60-64	
19572476-3	2009	The aim of the present study was to assess the influence of nickel-specific IFN-gamma secretion (marker of Th1 and Tc1 activity) and IL-5 secretion (Th2 and Tc2) on the clinical outcome (patch test score) in nickel-allergic patients.	Nickel	208-214	interleukin 5	Homo sapiens	133-137	
19572476-8	2009	We demonstrate that nickel-specific IL-5 secretion by PBMC is correlated with the intensity of patch test reaction (p=0.05), with no significant effect of IFN-gamma.	Nickel	20-26	interleukin 5	Homo sapiens	36-40	
19572476-9	2009	An increase in the nickel-specific IL-5 secretion from PBMC by 10 pg/ml is associated with a 10-20% increase (depending on statistical model) in the odds ratio of the patient to have a higher patch test score.	Nickel	19-25	interleukin 5	Homo sapiens	35-39	
18569071-7	2008	In contrast, detection of nickel-induced IL-5 was more comparable between methods, most likely due to the 7-fold higher IL-5 production per cell in response to nickel versus TT.	Nickel	26-32	interleukin 5	Homo sapiens	41-45	
18569071-7	2008	In contrast, detection of nickel-induced IL-5 was more comparable between methods, most likely due to the 7-fold higher IL-5 production per cell in response to nickel versus TT.	Nickel	160-166	interleukin 5	Homo sapiens	41-45	
18569071-7	2008	In contrast, detection of nickel-induced IL-5 was more comparable between methods, most likely due to the 7-fold higher IL-5 production per cell in response to nickel versus TT.	Nickel	160-166	interleukin 5	Homo sapiens	120-124	
18409353-6	2007	Both Th2/Tc2 (IL-4, IL-5, IL-13) and Th1/ Tc1 (IFNgamma) take their part in the development of contact allergy to nickel.	Nickel	114-120	interleukin 5	Homo sapiens	20-24	
15270870-5	2004	RESULTS: Only CD4+ CLA+ CD45RO+ and not CD8+ T cells proliferate and produce both type-1 (IFN-gamma) and type-2 (IL-5) cytokines in response to nickel.	Nickel	144-150	interleukin 5	Homo sapiens	113-117	
15030331-12	2004	Nickel-induced IL-2 production correlated well with IL-5 production in nickel-allergic patients regardless of their atopic status.	Nickel	0-6	interleukin 5	Homo sapiens	52-56	
15059101-7	2004	Only those nickel-sensitive individuals who clinically reacted to oral challenge with nickel (4 mg) had elevated levels of IL-5 in the serum, indicating an activation of type 2 T lymphocytes in the peripheral blood.	Nickel	11-17	interleukin 5	Homo sapiens	123-127	
15059101-7	2004	Only those nickel-sensitive individuals who clinically reacted to oral challenge with nickel (4 mg) had elevated levels of IL-5 in the serum, indicating an activation of type 2 T lymphocytes in the peripheral blood.	Nickel	86-92	interleukin 5	Homo sapiens	123-127	
10929769-5	2000	The analysis showed that the synthesis of IL-4 and IL-5 but not of IFN-gamma or TNF-alpha was significantly higher in the nickel-allergic individuals.	Nickel	122-128	interleukin 5	Homo sapiens	51-55	
10929769-11	2000	Our results indicate the possibility that IL-4 and IL-5 are involved in the pathogenesis of nickel-mediated contact dermatitis.	Nickel	92-98	interleukin 5	Homo sapiens	51-55