PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26155144-2	2014	In light of its known biological functions and its involvement in tissue pathology in other disease states, particularly in nickel-induced allergic contact dermatitis coexisting with DH, it would appear that the central and peripheral response by neutrophils and their mediators (e.g. neutrophil elastase - NE) in DH may be partially mediated by interleukin-6 (IL-6).	Nickel	124-130	interleukin 6	Homo sapiens	346-359	
27626938-4	2016	A subset of the pathway regulators, including interleukin-6, and JNK, were found to be linearly correlated with cell viability, and may function as molecular determinants of cytotoxic responses of BEAS-2B cells to nickel exposures.	Nickel	214-220	interleukin 6	Homo sapiens	46-59	
25256809-8	2015	T-cell receptor (TCR) activation of PBMCs and nickel (Ni(2+) ) treatments of human dermal microvascular endothelial cells (HDMECs) were performed resulting in IL-4, IL-6, IL-8 and IL-17 production.	Nickel	46-52	interleukin 6	Homo sapiens	165-169	
25256809-11	2015	Similarly, TSC inhibits overproduction of IL-4 and IL-17 in T-cell receptor (TCR)-activated PBMCs as well as nickel induction of IL-6 and IL-8 in HDMECs.	Nickel	109-115	interleukin 6	Homo sapiens	129-133	
26155144-2	2014	In light of its known biological functions and its involvement in tissue pathology in other disease states, particularly in nickel-induced allergic contact dermatitis coexisting with DH, it would appear that the central and peripheral response by neutrophils and their mediators (e.g. neutrophil elastase - NE) in DH may be partially mediated by interleukin-6 (IL-6).	Nickel	124-130	interleukin 6	Homo sapiens	361-365	
20600219-0	2010	Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2.	Nickel	104-110	interleukin 6	Homo sapiens	51-55	
22808498-8	2012	Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid.	Nickel	62-68	interleukin 6	Homo sapiens	157-161	
23564008-0	2013	The concentrations of IL-8 and IL-6 in gingival crevicular fluid during nickel-chromium alloy porcelain crown restoration.	Nickel	72-78	interleukin 6	Homo sapiens	31-35	
19136878-9	2009	White blood cells and IL-6 might be involved in inflammatory process of zinc fume exposure with zinc and copper increasing GSH, but nickel depleting it.	Nickel	132-138	interleukin 6	Homo sapiens	22-26	
18547706-7	2008	The metal allergens nickel and cobalt could be detected by measuring Interleukin-6 and macrophage inflammatory protein 1-beta (MIP-1beta, CCL-4) in coculture supernatants.	Nickel	20-26	interleukin 6	Homo sapiens	69-82	
9840004-8	1998	Increased IL-6 levels were observed in cultures exposed to copper (5-19-fold compared to untreated controls), zinc (16-fold), cobalt (12-fold), nickel (10-fold) and palladium (4-fold).	Nickel	144-150	interleukin 6	Homo sapiens	10-14	
15229366-0	2004	Microbial stimulation by Mycoplasma fermentans synergistically amplifies IL-6 release by human lung fibroblasts in response to residual oil fly ash (ROFA) and nickel.	Nickel	159-165	interleukin 6	Homo sapiens	73-77	
17312168-7	2007	Nickel-dependent HIF-1alpha activation primarily modulates expression of genes involved in proliferation, survival, metabolism, and signaling, albeit the induction of some proinflammatory nickel-response genes, most prominently IL-6, which we identified as novel bona fide HIF-1alpha target in this study, is also critically dependent on this pathway.	Nickel	0-6	interleukin 6	Homo sapiens	228-232	
35623502-0	2022	Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by STAT3 and C/EBPbeta.	Nickel	89-95	interleukin 6	Homo sapiens	25-29	
31943712-5	2020	The results showed that nickel could induce cell apoptosis, increase oxidative stress, and promote the expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, C-reaction protein.	Nickel	24-30	interleukin 6	Homo sapiens	208-212