PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31686395-11	2020	Nickel, a carcinogenic element upregulates the expression of Bak, cytochrome C, caspase-3, caspase-9, caspase-12, and GADD 153.	Nickel	0-6	caspase 3	Homo sapiens	80-89	
33570137-6	2021	Nickel exposure triggered apoptosis in concomitant with the decreased expression of anti-apoptotic B-cell lymphoma protein (Bcl-2) and increased caspase-3/7 activity.	Nickel	0-6	caspase 3	Homo sapiens	145-156	
28509315-0	2017	Caspase-3 as an important factor in the early cytotoxic effect of nickel on oral mucosa cells in patients treated orthodontically.	Nickel	66-72	caspase 3	Homo sapiens	0-9	
28509315-10	2017	The enhanced expression of caspase-3 was accompanied by increased nickel concentration in saliva.	Nickel	66-72	caspase 3	Homo sapiens	27-36	
28509315-11	2017	CONCLUSIONS: Our data suggests that nickel released from orthodontic appliances can activate caspase-3 and this mechanism may be partially responsible for the cytotoxic action of nickel in the oral cavity of orthodontically-treated individuals.	Nickel	36-42	caspase 3	Homo sapiens	93-102	
28509315-11	2017	CONCLUSIONS: Our data suggests that nickel released from orthodontic appliances can activate caspase-3 and this mechanism may be partially responsible for the cytotoxic action of nickel in the oral cavity of orthodontically-treated individuals.	Nickel	179-185	caspase 3	Homo sapiens	93-102	
25621996-10	2015	At the end of 131I therapy, CNE-2Z-NIS xenograft tumor cells expressed higher levels of NIS and caspase-3 and lower levels of Ki-67.	Nickel	35-38	caspase 3	Homo sapiens	96-105	
21382431-8	2011	Quantitative real-time PCR analysis demonstrated that following the exposure of A549 cells to nickel ferrite nanoparticles, the level of mRNA expressions of cell cycle checkpoint protein p53 and apoptotic proteins (bax, caspase-3 and caspase-9) were significantly up-regulated, whereas the expression of anti-apoptotic proteins (survivin and bcl-2) were down-regulated.	Nickel	94-100	caspase 3	Homo sapiens	220-229	
19538462-5	2010	Accordingly, increased activation of Caspase-8 and Caspase-3 following nickel treatment was observed.	Nickel	71-77	caspase 3	Homo sapiens	51-60	
27573304-13	2016	Immunohistochemical staining showed that HeLa-TERTNIS xenograft tumors expressed higher levels of NIS and caspase-3 and lower levels of Ki-67 than HeLa xenograft tumors.	Nickel	50-53	caspase 3	Homo sapiens	106-115	
23638002-6	2013	Further examination indicated that nickel released from 316L SS triggered the cell apoptosis via Fas-Caspase8-Caspase3 exogenous pathway.	Nickel	35-41	caspase 3	Homo sapiens	110-118