PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31686395-11 2020 Nickel, a carcinogenic element upregulates the expression of Bak, cytochrome C, caspase-3, caspase-9, caspase-12, and GADD 153. Nickel 0-6 caspase 3 Homo sapiens 80-89 33570137-6 2021 Nickel exposure triggered apoptosis in concomitant with the decreased expression of anti-apoptotic B-cell lymphoma protein (Bcl-2) and increased caspase-3/7 activity. Nickel 0-6 caspase 3 Homo sapiens 145-156 28509315-0 2017 Caspase-3 as an important factor in the early cytotoxic effect of nickel on oral mucosa cells in patients treated orthodontically. Nickel 66-72 caspase 3 Homo sapiens 0-9 28509315-10 2017 The enhanced expression of caspase-3 was accompanied by increased nickel concentration in saliva. Nickel 66-72 caspase 3 Homo sapiens 27-36 28509315-11 2017 CONCLUSIONS: Our data suggests that nickel released from orthodontic appliances can activate caspase-3 and this mechanism may be partially responsible for the cytotoxic action of nickel in the oral cavity of orthodontically-treated individuals. Nickel 36-42 caspase 3 Homo sapiens 93-102 28509315-11 2017 CONCLUSIONS: Our data suggests that nickel released from orthodontic appliances can activate caspase-3 and this mechanism may be partially responsible for the cytotoxic action of nickel in the oral cavity of orthodontically-treated individuals. Nickel 179-185 caspase 3 Homo sapiens 93-102 25621996-10 2015 At the end of 131I therapy, CNE-2Z-NIS xenograft tumor cells expressed higher levels of NIS and caspase-3 and lower levels of Ki-67. Nickel 35-38 caspase 3 Homo sapiens 96-105 21382431-8 2011 Quantitative real-time PCR analysis demonstrated that following the exposure of A549 cells to nickel ferrite nanoparticles, the level of mRNA expressions of cell cycle checkpoint protein p53 and apoptotic proteins (bax, caspase-3 and caspase-9) were significantly up-regulated, whereas the expression of anti-apoptotic proteins (survivin and bcl-2) were down-regulated. Nickel 94-100 caspase 3 Homo sapiens 220-229 19538462-5 2010 Accordingly, increased activation of Caspase-8 and Caspase-3 following nickel treatment was observed. Nickel 71-77 caspase 3 Homo sapiens 51-60 27573304-13 2016 Immunohistochemical staining showed that HeLa-TERTNIS xenograft tumors expressed higher levels of NIS and caspase-3 and lower levels of Ki-67 than HeLa xenograft tumors. Nickel 50-53 caspase 3 Homo sapiens 106-115 23638002-6 2013 Further examination indicated that nickel released from 316L SS triggered the cell apoptosis via Fas-Caspase8-Caspase3 exogenous pathway. Nickel 35-41 caspase 3 Homo sapiens 110-118