PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12767066-8 2003 We also observed a marked and specific increase of Cap43 mRNA levels in response to hypoxia or nickel in all VHL-positive cell lines. Nickel 95-101 N-myc downstream regulated 1 Homo sapiens 51-56 12767066-9 2003 Cellular expression of Cap43 mRNA in response to hypoxia or nickel thus is closely associated with VHL gene expression in renal cancer cells. Nickel 60-66 N-myc downstream regulated 1 Homo sapiens 23-28 12426141-2 2002 Acute exposure to nickel activates hypoxia-inducible transcription factor-1 (HIF-1), which strongly induces hypoxia-inducible genes, including the recently discovered tumor marker Cap43. Nickel 18-24 N-myc downstream regulated 1 Homo sapiens 180-185 12839937-5 2003 Acute exposure to nickel resulted in the accumulation of hypoxia-inducible transcription factor (HIF)-1, which strongly activated hypoxia-inducible genes, including the recently discovered tumor marker NDRG1 (Cap43). Nickel 18-24 N-myc downstream regulated 1 Homo sapiens 202-207 12839937-5 2003 Acute exposure to nickel resulted in the accumulation of hypoxia-inducible transcription factor (HIF)-1, which strongly activated hypoxia-inducible genes, including the recently discovered tumor marker NDRG1 (Cap43). Nickel 18-24 N-myc downstream regulated 1 Homo sapiens 209-214 12426142-6 2002 We also investigated the role of NF-kappaB in the induction of Cap43 by nickel compounds using dominant negative mutant Ikappabeta kinase b-KM BEAS-2B transfectants. Nickel 72-78 N-myc downstream regulated 1 Homo sapiens 63-68 33305529-9 2021 Intriguingly, NDRG1 interacts with metal ions, such as nickel, but is prone to aggregation in their presence. Nickel 55-61 N-myc downstream regulated 1 Homo sapiens 14-19 10646848-3 2000 We also show that a new gene, Cap43, is dependent upon HIF-1 because only HIF-1-proficient cells induced Cap43 when exposed to either hypoxia or nickel. Nickel 145-151 N-myc downstream regulated 1 Homo sapiens 30-35 10646848-3 2000 We also show that a new gene, Cap43, is dependent upon HIF-1 because only HIF-1-proficient cells induced Cap43 when exposed to either hypoxia or nickel. Nickel 145-151 N-myc downstream regulated 1 Homo sapiens 105-110 10646848-4 2000 We also show that glyceraldehyde-3-phosphate dehydrogenase, a gene induced by hypoxia through HIF-1, was similar to Cap43 in that it required HIF-1-proficient cells to be induced by either nickel or hypoxia. Nickel 189-195 N-myc downstream regulated 1 Homo sapiens 116-121 10527911-0 1999 Role of Ca(2+) in the regulation of nickel-inducible Cap43 gene expression. Nickel 36-42 N-myc downstream regulated 1 Homo sapiens 53-58 9605764-8 1998 The Cap43 gene was found to be induced by nickel not only in all tested human and rodent cell lines in vitro but also in several rat organs after oral exposure to NiCl2. Nickel 42-48 N-myc downstream regulated 1 Homo sapiens 4-9 22972152-1 2012 Human N-myc downstream-regulated gene 1 (NDRG1) is a metastasis suppressor gene with several potential functions, including cell differentiation, cell cycle regulation and response to hormones, nickel and stress. Nickel 194-200 N-myc downstream regulated 1 Homo sapiens 6-39 22972152-1 2012 Human N-myc downstream-regulated gene 1 (NDRG1) is a metastasis suppressor gene with several potential functions, including cell differentiation, cell cycle regulation and response to hormones, nickel and stress. Nickel 194-200 N-myc downstream regulated 1 Homo sapiens 41-46 19587996-0 2009 An NMR study on nickel binding sites in Cap43 protein fragments. Nickel 16-22 N-myc downstream regulated 1 Homo sapiens 40-45 21455298-5 2011 Nickel exposure increased the level of H3K4 trimethylation in both the promoters and coding regions of several genes including CA9 and NDRG1 that were increased in expression in A549 cells. Nickel 0-6 N-myc downstream regulated 1 Homo sapiens 135-140 19020710-2 2008 Its expression is regulated by nickel, cobalt, hypoxic condition and others; it is reported to be weaker in tumors than normal tissues; and NDRG1/Cap43 is considered to act suppressively to tumor metastasis. Nickel 31-37 N-myc downstream regulated 1 Homo sapiens 140-145 19414333-1 2009 Cap43 protein has been proven to be upregulated by nickel compounds or hypoxic stress, often during cell differentiation or cell growth arrest. Nickel 51-57 N-myc downstream regulated 1 Homo sapiens 0-5 15341671-1 2004 BACKGROUND: The expression of NDRG1 gene is induced by nickel, a transition metal sharing similar physical properties to cobalt. Nickel 55-61 N-myc downstream regulated 1 Homo sapiens 30-35 18281151-1 2008 Cap43 is a nickel- and calcium-inducible gene that plays important roles in the primary growth of malignant tumors, as well as in invasion and metastasis, most likely through its ability to induce cellular differentiation. Nickel 11-17 N-myc downstream regulated 1 Homo sapiens 0-5 16778198-1 2006 Cap43 has been identified as a nickel- and calcium-induced gene, and is also known as N-myc downstream-regulated gene 1 (NDRG1), Drg-1 and rit42. Nickel 31-37 N-myc downstream regulated 1 Homo sapiens 0-5 16707596-1 2006 PURPOSE: Cap43 is known as a nickel- and calcium-inducible gene. Nickel 29-35 N-myc downstream regulated 1 Homo sapiens 9-14 16288478-1 2006 Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes. Nickel 45-51 N-myc downstream regulated 1 Homo sapiens 135-140 16288478-1 2006 Exposure of human lung cells to carcinogenic nickel compounds in the presence of oxygen up-regulated carbonic anhydrase IX (CA IX) and NDRG1/Cap43, both known as intrinsic hypoxia markers and cancer-associated genes. Nickel 45-51 N-myc downstream regulated 1 Homo sapiens 141-146 16288478-8 2006 The repletion of intracellular ascorbate reversed the induction of CA IX and NDRG1/Cap43 caused by cell density or nickel exposure. Nickel 115-121 N-myc downstream regulated 1 Homo sapiens 77-82 16288478-8 2006 The repletion of intracellular ascorbate reversed the induction of CA IX and NDRG1/Cap43 caused by cell density or nickel exposure. Nickel 115-121 N-myc downstream regulated 1 Homo sapiens 83-88 15341671-10 2004 CONCLUSIONS: Hypoxia is an inducer of the NDRG1 gene, and nickel probably causes the induction of the gene by interacting with the oxygen sensory pathway. Nickel 58-64 N-myc downstream regulated 1 Homo sapiens 42-47