PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10751333-7 2000 In addition, we analyzed the effects of nickel and cobalt on the expression of VEGF in osteoblastic cells because these metallic ions mimic hypoxia by binding to the heme portion of oxygen-sensing molecules. Nickel 40-46 vascular endothelial growth factor A Homo sapiens 79-83 16283513-0 2005 Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression. Nickel 61-67 vascular endothelial growth factor A Homo sapiens 76-80 16283513-3 2005 Previous studies have revealed that nickel compounds can induce the expression of vascular endothelial growth factor (VEGF), which is a key mediator of angiogenesis both in physiological and pathologic conditions. Nickel 36-42 vascular endothelial growth factor A Homo sapiens 82-116 16283513-3 2005 Previous studies have revealed that nickel compounds can induce the expression of vascular endothelial growth factor (VEGF), which is a key mediator of angiogenesis both in physiological and pathologic conditions. Nickel 36-42 vascular endothelial growth factor A Homo sapiens 118-122 16283513-4 2005 In the present study, we investigated the potential roles of PI-3K, ERKs, p38 kinase and calcium signalling in VEGF induction by nickel in Cl 41 cells. Nickel 129-135 vascular endothelial growth factor A Homo sapiens 111-115 16283513-5 2005 Exposure of Cl 41 cells to nickel compounds led to VEGF induction in both time- and dose-dependent manners. Nickel 27-33 vascular endothelial growth factor A Homo sapiens 51-55 16283513-6 2005 Pre-treatment of Cl 41 cells with PI-3K inhibitor, wortmannin or Ly294002, resulted in a striking inhibition of VEGF induction by nickel compounds, implicating the role of PI-3K in the induction. Nickel 130-136 vascular endothelial growth factor A Homo sapiens 112-116 16283513-9 2005 Pre-treatment of Cl 41 cells with intracellular calcium chelator, but not calcium channel blocker, inhibited VEGF induction by nickel. Nickel 127-133 vascular endothelial growth factor A Homo sapiens 109-113 16283513-10 2005 Collectively these data demonstrate that PI-3K, ERKs and cytosolic calcium, but not p38 kinase, play essential roles in VEGF induction by nickel compounds. Nickel 138-144 vascular endothelial growth factor A Homo sapiens 120-124 10751333-9 2000 In addition, we found that nickel and cobalt both stimulate VEGF gene expression in a similar time- and dose-dependent manner, suggesting the presence of a hemelike oxygen-sensing mechanism similar to that of the EPO gene. Nickel 27-33 vascular endothelial growth factor A Homo sapiens 60-64 10751333-11 2000 These studies demonstrate that hypoxia, nickel, and cobalt regulate VEGF expression in osteoblasts via a similar mechanism, implicating the involvement of a heme-containing oxygen-sensing molecule. Nickel 40-46 vascular endothelial growth factor A Homo sapiens 68-72 22154009-0 2012 The effect of VEGF-immobilized nickel-free high-nitrogen stainless steel on viability and proliferation of vascular endothelial cells. Nickel 31-37 vascular endothelial growth factor A Homo sapiens 14-18 31353727-3 2019 flower proanthocyanidin fraction (LFPF) composed of (-)-epicatechin and proanthocyanidin A2 against vascular endothelial growth factor (VEGF) generation induced by nickel (Ni) in hepatocellular carcinoma (Hep G2) cells was studied. Nickel 164-170 vascular endothelial growth factor A Homo sapiens 136-140 26662142-2 2015 AIM: To highlight the expression of vascular endothelial growth factor (VEGF) in human paraprosthetic gingival mucosa exposed to nickel and copper compounds using the immunohistochemical technique. Nickel 129-135 vascular endothelial growth factor A Homo sapiens 36-70 26662142-2 2015 AIM: To highlight the expression of vascular endothelial growth factor (VEGF) in human paraprosthetic gingival mucosa exposed to nickel and copper compounds using the immunohistochemical technique. Nickel 129-135 vascular endothelial growth factor A Homo sapiens 72-76 9390328-7 1997 Hydrocortisone reduced the basal level as well as the nickel-induced upregulation of VEGF. Nickel 54-60 vascular endothelial growth factor A Homo sapiens 85-89 30724446-0 2019 Nickel-induced VEGF expression via regulation of Akt, ERK1/2, NFkappaB, and AMPK pathways in H460 cells. Nickel 0-6 vascular endothelial growth factor A Homo sapiens 15-19 30724446-3 2019 However, the signal transduction pathways leading to VEGF induction by nickel compounds are not well understood. Nickel 71-77 vascular endothelial growth factor A Homo sapiens 53-57 22865832-3 2013 In the present study, we designed a biomacromolecular layer-by-layer coating with heparin, vascular endothelial growth factor (VEGF), and fibronectin onto nickel-free titanium surface to improve blood compatibility and endothelial cell proliferation. Nickel 155-161 vascular endothelial growth factor A Homo sapiens 91-125 22154009-1 2012 Using ester bonds, vascular endothelial growth factor-A (VEGF-A) was immobilized on the surface of a novel biometal, nickel-free high-nitrogen stainless steel (HNS). Nickel 117-123 vascular endothelial growth factor A Homo sapiens 19-55 22154009-1 2012 Using ester bonds, vascular endothelial growth factor-A (VEGF-A) was immobilized on the surface of a novel biometal, nickel-free high-nitrogen stainless steel (HNS). Nickel 117-123 vascular endothelial growth factor A Homo sapiens 57-63 19403854-2 2009 The current study investigated the hypothesis that Cr(VI) actively signals through a signal transducer and activator of transcription 1 (STAT1)-dependent pathway to silence nickel (Ni)-induced expression of vascular endothelial cell growth factor A (VEGFA), an important mediator of lung injury and repair. Nickel 173-179 vascular endothelial growth factor A Homo sapiens 250-255