PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22583413-3	2012	Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells.	Nickel	0-6	matrix metallopeptidase 2	Homo sapiens	90-97	
22583413-3	2012	Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells.	Nickel	0-6	matrix metallopeptidase 2	Homo sapiens	180-187	
17518770-0	2007	Analysis of the signal transduction pathway of nickel-induced matrix metalloproteinase-2 expression in the human keratinocytes in vitro: preliminary findings.	Nickel	47-53	matrix metallopeptidase 2	Homo sapiens	62-88	
21401309-0	2011	The role of hypoxia inducible factor-1alpha in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles.	Nickel	118-124	matrix metallopeptidase 2	Homo sapiens	61-66	
22808498-8	2012	Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid.	Nickel	62-68	matrix metallopeptidase 2	Homo sapiens	137-142	
21473897-3	2011	In this in vitro study, we found that nickel, as nickel chloride, could significantly enhance the invasive potential of human lung cancer cells, accompanied by elevated expression of IL-8, TGF-beta, MMP2 and MMP9 in human lung cancer cells.	Nickel	38-44	matrix metallopeptidase 2	Homo sapiens	199-203	
18409814-5	2007	Nickel contact at very low concentrations (10(-5), 10(-6) M) induced upregulation of MMP-2 and IL-8 mRNA production; chromium contact at very low concentrations killed all cells.	Nickel	0-6	matrix metallopeptidase 2	Homo sapiens	85-90	
17518770-2	2007	We previously showed that matrix metalloproteinase-2 (MMP-2) gene expression was induced by nickel in nontumorigenic human keratinocytes cell line (HaCat).	Nickel	92-98	matrix metallopeptidase 2	Homo sapiens	26-52	
17518770-2	2007	We previously showed that matrix metalloproteinase-2 (MMP-2) gene expression was induced by nickel in nontumorigenic human keratinocytes cell line (HaCat).	Nickel	92-98	matrix metallopeptidase 2	Homo sapiens	54-59	
17518770-5	2007	RESULTS: Our results indicate that nickel-induced MMP-2 production was inhibited with PTK, PKC and AP-1 specific inhibitors.	Nickel	35-41	matrix metallopeptidase 2	Homo sapiens	50-55	
17518770-7	2007	CONCLUSIONS: Using HaCat, we showed that curcumin and genistein can revert nickel-induced MMP-2 upregulation.	Nickel	75-81	matrix metallopeptidase 2	Homo sapiens	90-95	
15020194-7	2004	Nickel contact induced upregulation of MMP-2 and IL-8 mRNA production.	Nickel	0-6	matrix metallopeptidase 2	Homo sapiens	39-44	
16581223-7	2006	Nickel and chromium showed different results, with an upregulation of MMP-2 mRNA production in nickel-treated cells while chromium exposure down-regulated MMP-2 mRNA production.	Nickel	0-6	matrix metallopeptidase 2	Homo sapiens	70-75	
16581223-7	2006	Nickel and chromium showed different results, with an upregulation of MMP-2 mRNA production in nickel-treated cells while chromium exposure down-regulated MMP-2 mRNA production.	Nickel	0-6	matrix metallopeptidase 2	Homo sapiens	155-160	
16581223-7	2006	Nickel and chromium showed different results, with an upregulation of MMP-2 mRNA production in nickel-treated cells while chromium exposure down-regulated MMP-2 mRNA production.	Nickel	95-101	matrix metallopeptidase 2	Homo sapiens	70-75	
30109310-3	2018	Herein, MMP-2-responsive nanoprobes were prepared by immobilizing fluorescent fusion proteins on nickel ferrite nanoparticles via the His-tag nickel chelation mechanism.	Nickel	97-103	matrix metallopeptidase 2	Homo sapiens	8-13	
35150872-0	2022	Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway.	Nickel	0-6	matrix metallopeptidase 2	Homo sapiens	94-98	
29058417-0	2017	Cell-Permeable, MMP-2 Activatable, Nickel Ferrite and His-Tagged Fusion Protein Self-Assembled Fluorescent Nanoprobe for Tumor Magnetic-Targeting and Imaging.	Nickel	35-41	matrix metallopeptidase 2	Homo sapiens	16-21