PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26476415-0	2016	Cytoprotective role of autophagy against BH3 mimetic gossypol in ATG5 knockout cells generated by CRISPR-Cas9 endonuclease.	Gossypol	53-61	autophagy related 5	Homo sapiens	65-69	
29938581-3	2018	AT 101 ([-]-gossypol), a natural compound from cotton seeds, induces ACD in glioma cells as confirmed here by CRISPR/Cas9 knockout of ATG5 that partially, but significantly rescued cell survival following AT 101 treatment.	Gossypol	8-20	autophagy related 5	Homo sapiens	134-138	
26476415-3	2016	The MTT assay revealed that the inhibitory effect of gossypol was weaker on ATG5 knockout cells than that on the wild type (WT) cells.	Gossypol	53-61	autophagy related 5	Homo sapiens	76-80	
26476415-5	2016	However, Cyto-ID autophagy assay revealed that gossypol induced ATG5- and LC3-independent autophagy in ATG5 knockout cells.	Gossypol	47-55	autophagy related 5	Homo sapiens	64-68	
26476415-5	2016	However, Cyto-ID autophagy assay revealed that gossypol induced ATG5- and LC3-independent autophagy in ATG5 knockout cells.	Gossypol	47-55	autophagy related 5	Homo sapiens	103-107	
26476415-6	2016	Moreover, gossypol acts as an autophagy inducer in ATG5 knockout cells while blocking the later stages of the autophagy process in WT cells, which was determined by measuring autophagic flux after co-treatment of gossypol with chloroquine (late-stage autophagy inhibitor).	Gossypol	10-18	autophagy related 5	Homo sapiens	51-55	
26476415-7	2016	On the other hand, inhibition of autophagy with 3-MA or Beclin-1 siRNA caused a partial increase in the sensitivity to gossypol in ATG5 knockout cells, but not in the WT cells.	Gossypol	119-127	autophagy related 5	Homo sapiens	131-135	
26476415-8	2016	Together, our findings suggest that the resistance to gossypol in ATG5 knockout cells is associated with increased cytoprotective autophagy, independent of ATG5.	Gossypol	54-62	autophagy related 5	Homo sapiens	66-70	
20930561-4	2010	Furthermore, (-)-gossypol-induced autophagy is Beclin 1- and Atg5-dependent.	Gossypol	17-25	autophagy related 5	Homo sapiens	61-65	
20577262-4	2011	The (-)-gossypol-induced autophagy is dependent on Beclin1 and Atg5.	Gossypol	8-16	autophagy related 5	Homo sapiens	63-67	
20529838-6	2010	Further, Atg5 knockdown also reduces gossypol-mediated autophagy.	Gossypol	37-45	autophagy related 5	Homo sapiens	9-13	
20529838-8	2010	Notably, we found that gossypol-mediated apoptotic cell death was potentiated by treatment with the autophagy inhibitor wortmannin or with small interfering RNA against essential autophagy genes (Vps34, Beclin 1, and Atg5).	Gossypol	23-31	autophagy related 5	Homo sapiens	217-221	
20587533-6	2010	Lentiviral knockdown of Beclin1 and Atg5 in U87, U343, and MZ-54 cells strongly diminished the extent of cell death induced by (-)-gossypol and combined treatment with TMZ, indicating that autophagy contributed to this type of cell death.	Gossypol	127-139	autophagy related 5	Homo sapiens	36-40