PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27027512-4	2016	The phosphorylation of insulin receptor, insulin receptor substrate (IRS)-1, glycogen synthase kinase-3beta, PI3K, and Akt was increased in Umb (20 and 40 mg/kg) treatment according to Western blot analysis.	7-hydroxycoumarin	140-143	AKT serine/threonine kinase 1	Rattus norvegicus	119-122	
27646771-0	2017	Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced rats by attenuating neuronal apoptosis via regulating ROCK/Akt pathway.	7-hydroxycoumarin	0-13	AKT serine/threonine kinase 1	Rattus norvegicus	152-155	
27646771-5	2017	Rats under CUMS stimulation treated with umbelliferone (15mg/kg, 30mg/kg) showed reduced neuronal apoptosis, as well as inhibited inflammatory cytokines levels by down-regulating Rho-associated protein kinase (ROCK) signaling and up-regulating protein kinase B (Akt) signaling.	7-hydroxycoumarin	41-54	AKT serine/threonine kinase 1	Rattus norvegicus	262-265	
27646771-6	2017	In conclusion, umbelliferone showed neuroprotective effects on CUMS-induced model of depression, which was associated with the inhibition of neuronal apoptosis modulated by ROCK/Akt pathway.	7-hydroxycoumarin	15-28	AKT serine/threonine kinase 1	Rattus norvegicus	178-181