PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28081450-8	2017	RESULTS: HPA siRNA and heparanase inhibitor sulodexide could attenuate the increasing inflammatory factors (TNF-alpha and IL-1beta) in AGEs-stimulated macrophages.	glucuronyl glucosamine glycan sulfate	44-54	heparanase	Homo sapiens	23-33	
23095131-0	2012	A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase-1 and prevents FGF-2-induced renal epithelial-mesenchymal transition.	glucuronyl glucosamine glycan sulfate	29-39	heparanase	Homo sapiens	74-86	
23095131-4	2012	Well known Heparanase-1 inhibitors are heparin(s) and sulodexide, a low-molecular weight heparin - dermatan sulphate blend, which is effective in the treatment of DN.	glucuronyl glucosamine glycan sulfate	54-64	heparanase	Homo sapiens	11-23	
23095131-5	2012	METHODS: We have investigated the inhibition by sulodexide and its components of Heparanase-1 by an ELISA assay.	glucuronyl glucosamine glycan sulfate	48-58	heparanase	Homo sapiens	81-93	
23095131-7	2012	RESULTS: Results show that sulodexide is an effective heparanase-1 inhibitor, exclusively in virtue to the heparin component, with an IC50 of 5 mug/ml.	glucuronyl glucosamine glycan sulfate	27-37	heparanase	Homo sapiens	54-66	
23095131-9	2012	Moreover, sulodexide prevents FGF-2 induced heparanase-1 and MMP9 increase switching off the autocrine loop that FGF-2 activates to support its signal.	glucuronyl glucosamine glycan sulfate	10-20	heparanase	Homo sapiens	44-56	
23095131-10	2012	CONCLUSIONS: The findings highlight the capacity of sulodexide to inhibit heparanase-1 and to control tubular fibrosis triggered by epithelial-mesenchymal transition.	glucuronyl glucosamine glycan sulfate	52-62	heparanase	Homo sapiens	74-86