PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28651842-0	2017	Sulodexide prevents activation of the PLA2/COX-2/VEGF inflammatory pathway in human retinal endothelial cells by blocking the effect of AGE/RAGE.	glucuronyl glucosamine glycan sulfate	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48	
28651842-2	2017	We tested the hypothesis that sulodexide (SDX), a highly purified glycosaminoglycan composed of 80% iduronylglycosaminoglycan sulfate and 20% dermatan sulfate, protects human retinal endothelial cells (HREC) from high glucose (HG)-induced damage, through the suppression of inflammatory ERK/cPLA2/COX-2/PGE2 pathway, by blocking the effect of advanced glycation end-products (AGEs).	glucuronyl glucosamine glycan sulfate	30-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	297-302	
28651842-2	2017	We tested the hypothesis that sulodexide (SDX), a highly purified glycosaminoglycan composed of 80% iduronylglycosaminoglycan sulfate and 20% dermatan sulfate, protects human retinal endothelial cells (HREC) from high glucose (HG)-induced damage, through the suppression of inflammatory ERK/cPLA2/COX-2/PGE2 pathway, by blocking the effect of advanced glycation end-products (AGEs).	glucuronyl glucosamine glycan sulfate	42-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	297-302	
28651842-9	2017	These data show that SDX protects HREC from HG damage and suggest that it counteracts the activation of ERK/cPLA2/COX-2/PGE2 pathway by reducing AGE-related signaling and downstream NFkappaB activity.	glucuronyl glucosamine glycan sulfate	21-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119