PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25634756-6	2015	Insignificant decreases of NF-kappaB p65 activation and HMGB1 release were observed in H/R-induced neonatal cultured cardiomyocytes treated with DOB, when compared to the control group.	Dobutamine	145-148	high mobility group box 1	Rattus norvegicus	56-61	
23531454-0	2013	Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo.	Dobutamine	0-10	high mobility group box 1	Rattus norvegicus	78-103	
23531454-2	2013	The present study aimed to investigate whether dobutamine, a selective beta1-adrenergic receptor agonist, could inhibit HMGB1 release via beta1-adrenergic receptor-mediated HO-1 induction and attenuate myocardial ischemia/reperfusion (I/R) injury in rats.	Dobutamine	47-57	high mobility group box 1	Rattus norvegicus	120-125	
23531454-7	2013	RESULTS: Dobutamine significantly and dose-dependently attenuated myocardial I/R injury, reduced oxidative stress, and caused the induction of HO-1, the reduction of NF-kappaB activation and HMGB1 over expression.	Dobutamine	9-19	high mobility group box 1	Rattus norvegicus	191-196	
23531454-9	2013	CONCLUSIONS: The present study demonstrated that dobutamine mediated the induction of HO-1 by selectively stimulating beta1-adrenergic receptor via PI3K and p38 MAPK, which inhibited HMGB1 release and attenuated rat myocardial I/R injury in vivo.	Dobutamine	49-59	high mobility group box 1	Rattus norvegicus	183-188	
25388343-6	2014	Meanwhile, dobutamine significantly and dose-dependently mediated the induction of HO-1 (P < 0.05), the expression of NF-kappaB (P < 0.05) and HMGB1 (P < 0.05).	Dobutamine	11-21	high mobility group box 1	Rattus norvegicus	149-154	
23726240-0	2014	Dobutamine-mediated heme oxygenase-1 induction via P13K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo.	Dobutamine	0-10	high mobility group box 1	Rattus norvegicus	78-103