PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1859148-3	1991	Dobutamine is a synthetic catecholamine that acts on alpha-1, beta-1 and beta-2 adrenergic receptors.	Dobutamine	0-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	73-79	
2736968-7	1989	These data are consistent with the hypothesis that the beta 2-adrenergic action of dobutamine vasodilates the previously constricted peripheral circulation, enhances tissue perfusion by improving micro-circulatory flow distribution, and improves DO2 and VO2.	Dobutamine	83-93	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	55-61	
2864131-3	1985	Dobutamine contracted small coronary arteries at 10(-5) M concentrations, then relaxed them at 10(-4) M. The beta1-adrenoceptor antagonist metoprolol contracted coronary arteries relaxed by either dobutamine or terbutaline, but the beta2 antagonist H35/25 did so only in high and probably nonselective concentrations.	Dobutamine	0-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	232-237	
6150925-5	1984	Compared with the latter, the beta 1-selective agonist dobutamine increases myocardial contractile force and cardiac output with less beta 2-mediated vasodilation and hypotension.	Dobutamine	55-65	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	134-140	
6084778-6	1984	On the contrary, combination of dobutamine (100 microM) and procaterol (10 microM) resulted in activation of adenylate cyclase which was not different from that evoked by saturating concentration of isoprenaline (10 microM), indicating that dobutamine (beta 1) and procaterol (beta 2) produce adenylate cyclase activation through stimulation of different beta-adrenoceptor subtypes.	Dobutamine	32-42	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	277-283	
18445058-1	2008	High-dose dobutamine used in dobutamine stress echocardiography (DSE) has hemodynamically based side effects due to a variable combination of beta1 (inotropic) and beta2 (vasodilator) effects.	Dobutamine	10-20	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	142-169	
18445058-1	2008	High-dose dobutamine used in dobutamine stress echocardiography (DSE) has hemodynamically based side effects due to a variable combination of beta1 (inotropic) and beta2 (vasodilator) effects.	Dobutamine	29-39	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	142-169	
10630826-9	1999	Dobutamine is a beta1-, beta2-, and alpha1-adrenergic agonist.	Dobutamine	0-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	24-29	
9396426-13	1997	The hyperemic response to dobutamine is in excess of that predicted by rate-pressure product and reflects the unmeasured inotropic, oxygen-wasting, and beta2-agonist effects of the drug.	Dobutamine	26-36	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	152-157	
7895322-16	1994	These levels were not modified by a dobutamine-induced beta-2 stimulation.	Dobutamine	36-46	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	55-61