PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25887954-10	2015	Pretreatment with nifedipine not only significantly blocked the enhancing effects of DOB on LPS-induced elevation in cytosolic Ca(2+) concentration and CaMKII phosphorylation in cardiomyocytes, but also partly reversed the effects of DOB on caspase-9 and caspase-3/7 activities in LPS-treated cardiomyocytes.	Dobutamine	85-88	toll-like receptor 4	Mus musculus	92-95	
25887954-7	2015	RESULTS: LPS induced apoptosis in adult mouse ventricular myocytes, dobutamine (DOB), a beta1-AR agonist, promoted apoptosis, caspase-8, 9 and 3 activation and increased cytosolic Ca(2+) concentration in LPS-challenged cardiomyocytes.	Dobutamine	68-78	toll-like receptor 4	Mus musculus	204-207	
25887954-7	2015	RESULTS: LPS induced apoptosis in adult mouse ventricular myocytes, dobutamine (DOB), a beta1-AR agonist, promoted apoptosis, caspase-8, 9 and 3 activation and increased cytosolic Ca(2+) concentration in LPS-challenged cardiomyocytes.	Dobutamine	80-83	toll-like receptor 4	Mus musculus	204-207	
25887954-8	2015	DOB also up-regulated TNF-alpha expression, decreased Bcl-2 levels, promoted Bax translocation to mitochondria, mitochondrial membrane potential loss and cytochrome c release as well as IkappaBalpha, p38 MAPK, JNK and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) phosphorylation in LPS-treated cardiomyocytes.	Dobutamine	0-3	toll-like receptor 4	Mus musculus	292-295	
29523072-5	2018	Dobutamine depressed the inflammatory response by modifying the toll-like receptor-4 signalling pathways, including interferon regulatory factors and nuclear factor kappa B activation in experimental paradigm 1.	Dobutamine	0-10	toll-like receptor 4	Mus musculus	64-84	
25887954-10	2015	Pretreatment with nifedipine not only significantly blocked the enhancing effects of DOB on LPS-induced elevation in cytosolic Ca(2+) concentration and CaMKII phosphorylation in cardiomyocytes, but also partly reversed the effects of DOB on caspase-9 and caspase-3/7 activities in LPS-treated cardiomyocytes.	Dobutamine	85-88	toll-like receptor 4	Mus musculus	281-284	
25887954-10	2015	Pretreatment with nifedipine not only significantly blocked the enhancing effects of DOB on LPS-induced elevation in cytosolic Ca(2+) concentration and CaMKII phosphorylation in cardiomyocytes, but also partly reversed the effects of DOB on caspase-9 and caspase-3/7 activities in LPS-treated cardiomyocytes.	Dobutamine	234-237	toll-like receptor 4	Mus musculus	92-95