PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34982427-8	2021	The PI3K/Akt signal pathway appears to be central to the anti-tumor activity of the coumarins analyzed in this review.	Coumarins	84-93	AKT serine/threonine kinase 1	Homo sapiens	9-12	
33344242-3	2020	In particular, coumarins have very significant anti-tumor abilities and a variety of anti-tumor mechanisms, including inhibition of carbonic anhydrase, targeting PI3K/Akt/mTOR signaling pathways, inducing cell apoptosis protein activation, inhibition of tumor multidrug resistance, inhibition of microtubule polymerization, regulating the reactive oxygen species, and inhibition of tumor angiogenesis, etc.	Coumarins	15-24	AKT serine/threonine kinase 1	Homo sapiens	167-170	
33556550-7	2021	RESULTS: Coumarins have been reported to downregulate RANKL-RANK signaling and various downstream signaling pathways required for osteoclast development, such as NF-kappaB, MAPK, Akt, and Ca2+ signaling, as well as pathways downstream of the nuclear factor of activated T-cells (NFATc1), including tartrate-resistant acid phosphatase (TRAP), cathepsin K (CTSK), and matrix metalloproteinase 9 (MMP-9).	Coumarins	9-18	AKT serine/threonine kinase 1	Homo sapiens	179-182