PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3056073-1 1988 4-Methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, is a possible future drug for the treatment of methanol and ethylene glycol intoxications and the severe ethanol-disulfiram reaction. Fomepizole 0-16 aldo-keto reductase family 1 member A1 Homo sapiens 41-62 3056073-1 1988 4-Methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, is a possible future drug for the treatment of methanol and ethylene glycol intoxications and the severe ethanol-disulfiram reaction. Fomepizole 18-22 aldo-keto reductase family 1 member A1 Homo sapiens 41-62 3056077-10 1988 Hepatocytes treated with 4-methylpyrazole, an inhibitor of ADH, were partially protected from ethanol effects. Fomepizole 25-41 aldo-keto reductase family 1 member A1 Homo sapiens 59-62 6377951-4 1984 Oral pretreatment with the alcohol dehydrogenase inhibitor, 4-methylpyrazole, reduced ethanol elimination by 15-25% and strongly suppressed acetaldehyde accumulation. Fomepizole 60-76 aldo-keto reductase family 1 member A1 Homo sapiens 27-48 3166980-4 1988 1,10-Phenanthroline and 4-methylpyrazole competitively inhibit both alcohol dehydrogenase catalyzed ethanol and 3 beta-hydroxy-5 beta-steroid oxidation demonstrating that the catalysis of both types of substrates occurs at the same active site. Fomepizole 24-40 aldo-keto reductase family 1 member A1 Homo sapiens 68-89 2936266-3 1985 The cutaneous reaction to primary alcohols can be totally blocked by pretreatment with 4-methylpyrazole, a potent inhibitor of alcohol dehydrogenase. Fomepizole 87-103 aldo-keto reductase family 1 member A1 Homo sapiens 127-148 6353979-4 1983 4-Methylpyrazole, an alcohol dehydrogenase inhibitor, efficiently reduced blood acetaldehyde levels when injected intravenously (7 mg/kg) at the height of the reaction. Fomepizole 0-16 aldo-keto reductase family 1 member A1 Homo sapiens 21-42 7030108-1 1981 4-methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, rapidly abolished the accumulation of acetaldehyde following alcohol ingestion both in volunteers pretreated with the Antabuse analog calcium carbimide and in an antabuse-treated alcoholic. Fomepizole 0-16 aldo-keto reductase family 1 member A1 Homo sapiens 41-62 7030108-1 1981 4-methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, rapidly abolished the accumulation of acetaldehyde following alcohol ingestion both in volunteers pretreated with the Antabuse analog calcium carbimide and in an antabuse-treated alcoholic. Fomepizole 18-22 aldo-keto reductase family 1 member A1 Homo sapiens 41-62 26551875-5 2016 Although ethanol can be effective in these poisonings, there are substantial practical problems with its use and so fomepizole, a potent competitive inhibitor of alcohol dehydrogenase, was developed for a hopefully better treatment for metabolically-toxic alcohol poisonings. Fomepizole 116-126 aldo-keto reductase family 1 member A1 Homo sapiens 162-183 415870-0 1977 Ethanol-induced hypoglycaemia in man: its suppression by the alcohol dehydrogenase inhibitor 4-methylpyrazole. Fomepizole 93-109 aldo-keto reductase family 1 member A1 Homo sapiens 61-82 415870-1 1977 Infusion of ethanol (0.6 g/kg body wt) caused marked hypoglycaemia in subjects fasted for 36 h. Previous administration of the alcohol dehydrogenase (ADH) inhibitor 4-methylpyrazole (4-MP, 7 mg/kg body wt i.v.) Fomepizole 165-181 aldo-keto reductase family 1 member A1 Homo sapiens 127-148 31214899-1 2019 Fomepizole is used as an antidote to treat methanol poisoning due to its selectivity towards alcohol dehydrogenase. Fomepizole 0-10 aldo-keto reductase family 1 member A1 Homo sapiens 93-114 172084-0 1975 Human liver alcohol dehydrogenase--inhibition of methanol activity by pyrazole, 4-methylpyrazole, 4-hydroxymethylpyrazole and 4-carboxypyrazole. Fomepizole 80-96 aldo-keto reductase family 1 member A1 Homo sapiens 12-33 33425517-6 2020 The treatment of ethylene glycol poisoning consists of supportive care, sodium bicarbonate, and the use of an antidote (ethanol or fomepizole) which inhibits alcohol dehydrogenase and thereby prevents the formation of toxic metabolites. Fomepizole 131-141 aldo-keto reductase family 1 member A1 Homo sapiens 158-179 16208625-6 2005 The aim of the study was to evaluate the effect of alcohol dehydrogenase (ADH) inhibitors and substrates: cimetidine, EDTA, 4-methylpyrazole (4-MP), Ukrain and ethanol on LDH activity. Fomepizole 142-146 aldo-keto reductase family 1 member A1 Homo sapiens 74-77 26915245-6 2016 Fomepizole is the antidote for methanol and ethyleneglycol, blocking alcohol dehydrogenase. Fomepizole 0-10 aldo-keto reductase family 1 member A1 Homo sapiens 69-90 23352969-4 2013 MAIN METHODS: Chronic ethanol treated VL-17A cells over-expressing ADH and CYP2E1 were pretreated with the specific CYP2E1 inhibitor - diallyl sulfide or ADH inhibitor - pyrazole or ADH and CYP2E1 inhibitor - 4-methyl pyrazole. Fomepizole 207-226 aldo-keto reductase family 1 member A1 Homo sapiens 67-70 23352969-6 2013 KEY FINDINGS: Inhibition of CYP2E1 with 10 muM diallyl sulfide or ADH with 2mM pyrazole or ADH and CYP2E1 with 5mM 4-methyl pyrazole led to decreased oxidative stress and toxicity in chronic ethanol (100 mM) treated VL-17A cells. Fomepizole 115-132 aldo-keto reductase family 1 member A1 Homo sapiens 66-69 21468195-2 2010 The current recommendation suggests that alcohol dehydrogenase inhibitor fomepizole is preferred to ethanol in treatment of methanol and ethylene glycol poisoning, but analysis of the enzyme kinetics indicates that ethanol is a better alternative. Fomepizole 73-83 aldo-keto reductase family 1 member A1 Homo sapiens 41-62 17870485-2 2007 Recent trials have demonstrated that fomepizole effectively blocks alcohol dehydrogenase (ADH) in toxic alcohol overdoses, and may eliminate the need for emergent hemodialysis and intensive care unit admission. Fomepizole 37-47 aldo-keto reductase family 1 member A1 Homo sapiens 67-88 17870485-2 2007 Recent trials have demonstrated that fomepizole effectively blocks alcohol dehydrogenase (ADH) in toxic alcohol overdoses, and may eliminate the need for emergent hemodialysis and intensive care unit admission. Fomepizole 37-47 aldo-keto reductase family 1 member A1 Homo sapiens 90-93 17870485-9 2007 Fomepizole was used for ADH blockade in 12/20 cases; ETOH infusions in 15/20 cases (combined ETOH and fomepizole use in 7/20). Fomepizole 0-10 aldo-keto reductase family 1 member A1 Homo sapiens 24-27 15578220-6 2005 We report on the use of fomepizole (4-methylpyrazole),a new and potent inhibitor of alcohol dehydrogenase, in a 3-year-old boy after the intake of a toxic amount of methanol. Fomepizole 24-34 aldo-keto reductase family 1 member A1 Homo sapiens 84-105 15578220-6 2005 We report on the use of fomepizole (4-methylpyrazole),a new and potent inhibitor of alcohol dehydrogenase, in a 3-year-old boy after the intake of a toxic amount of methanol. Fomepizole 36-52 aldo-keto reductase family 1 member A1 Homo sapiens 84-105 16035197-2 2005 Fomepizole (4-methylpyrazole) is a potent competitive inhibitor of alcohol dehydrogenase and is used as an antidote to treat methanol poisonings. Fomepizole 0-10 aldo-keto reductase family 1 member A1 Homo sapiens 67-88 16035197-2 2005 Fomepizole (4-methylpyrazole) is a potent competitive inhibitor of alcohol dehydrogenase and is used as an antidote to treat methanol poisonings. Fomepizole 12-28 aldo-keto reductase family 1 member A1 Homo sapiens 67-88 15135311-9 2004 The ethanol-induced changes occurring in this cell line were negated by addition of the ADH inhibitor, 4-methylpyrazole (4-MP), indicating the effects were due to ethanol metabolism. Fomepizole 103-119 aldo-keto reductase family 1 member A1 Homo sapiens 88-91 15135311-9 2004 The ethanol-induced changes occurring in this cell line were negated by addition of the ADH inhibitor, 4-methylpyrazole (4-MP), indicating the effects were due to ethanol metabolism. Fomepizole 121-125 aldo-keto reductase family 1 member A1 Homo sapiens 88-91 10793034-0 2000 Childhood diethylene glycol poisoning treated with alcohol dehydrogenase inhibitor fomepizole and hemodialysis. Fomepizole 83-93 aldo-keto reductase family 1 member A1 Homo sapiens 51-72 12053840-3 2002 The use of 4-methylpyrazole, an inhibitor of alcohol dehydrogenase, is a new and effective treatment for patients exposed to toxic alcohols. Fomepizole 11-27 aldo-keto reductase family 1 member A1 Homo sapiens 45-66 11172179-3 2001 We performed a multicenter study to evaluate fomepizole, an inhibitor of alcohol dehydrogenase, in the treatment of patients with methanol poisoning. Fomepizole 45-55 aldo-keto reductase family 1 member A1 Homo sapiens 73-94 11128434-4 2000 Fomepizole, an inhibitor of alcohol dehydrogenase, slows the metabolism of these substances and is now approved by the US Food and Drug Administration for use in ethylene glycol intoxication. Fomepizole 0-10 aldo-keto reductase family 1 member A1 Homo sapiens 28-49 12399160-10 2002 Metabolism and residue formation were blocked by the ADH inhibitor 4-methyl pyrazole (4-MP). Fomepizole 67-84 aldo-keto reductase family 1 member A1 Homo sapiens 53-56 12399160-10 2002 Metabolism and residue formation were blocked by the ADH inhibitor 4-methyl pyrazole (4-MP). Fomepizole 86-90 aldo-keto reductase family 1 member A1 Homo sapiens 53-56 11434452-11 2001 Like ethanol, fomepizole inhibits alcohol dehydrogenase; however it does so without producing serious adverse effects. Fomepizole 14-24 aldo-keto reductase family 1 member A1 Homo sapiens 34-55 11762672-6 2001 This case report confirms highly efficient inhibition of alcohol dehydrogenase by fomepizole, as well as demonstrate the safety of fomepizole in a patient already exhibiting end-organ retinal toxicity. Fomepizole 82-92 aldo-keto reductase family 1 member A1 Homo sapiens 57-78 11762672-7 2001 The potential for fomepizole to inhibit retinol dehydrogenase, an isoenzyme of alcohol dehydrogenase essential to vision, did not appear to be clinically significant in this symptomatic methanol-poisoned patient. Fomepizole 18-28 aldo-keto reductase family 1 member A1 Homo sapiens 79-100 11099610-4 2000 A new alcohol dehydrogenase inhibitor, fomepizole (4-methylpyrazole), was approved in 1997 for patients at least 12 years old with suspected or confirmed EG poisoning. Fomepizole 39-49 aldo-keto reductase family 1 member A1 Homo sapiens 6-27 11099610-4 2000 A new alcohol dehydrogenase inhibitor, fomepizole (4-methylpyrazole), was approved in 1997 for patients at least 12 years old with suspected or confirmed EG poisoning. Fomepizole 51-67 aldo-keto reductase family 1 member A1 Homo sapiens 6-27 10793034-6 2000 We report a case of DEG ingestion in a 17-month-old girl who was managed with activated charcoal, fomepizole (a recently available alcohol dehydrogenase inhibitor), and hemodialysis (HD). Fomepizole 98-108 aldo-keto reductase family 1 member A1 Homo sapiens 131-152 1616124-4 1992 Selective inhibition of class I ADH by 4-methylpyrazole further increases the specificity. Fomepizole 39-55 aldo-keto reductase family 1 member A1 Homo sapiens 32-35 9398786-1 1997 Treatment of human methanol poisoning with the alcohol dehydrogenase inhibitor, 4-methylpyrazole (fomepizole), has not been previously described. Fomepizole 80-96 aldo-keto reductase family 1 member A1 Homo sapiens 47-68 9398786-1 1997 Treatment of human methanol poisoning with the alcohol dehydrogenase inhibitor, 4-methylpyrazole (fomepizole), has not been previously described. Fomepizole 98-108 aldo-keto reductase family 1 member A1 Homo sapiens 47-68 8032149-10 1994 4-methylpyrazole inhibits H. pylori ADH, and suppresses its growth during culture. Fomepizole 0-16 aldo-keto reductase family 1 member A1 Homo sapiens 36-39 7999766-7 1994 A Tyr93Phe mutant exhibits decreased kcat values for substrates in general and correlates with inhibition of alcohol dehydrogenase activity by 4-methylpyrazole, a potent inhibitor of the class I enzymes. Fomepizole 143-159 aldo-keto reductase family 1 member A1 Homo sapiens 109-130 2642704-7 1989 The oxidation of PEG was inhibited by the ADH inhibitor 4-methylpyrazole. Fomepizole 56-72 aldo-keto reductase family 1 member A1 Homo sapiens 42-45 2129178-4 1990 It is referred to the therapy by means of 4-methyl pyrazol which prevents the intoxication of ethylene glycol, whereby this substance in an effective inhibitor of the alcohol dehydrogenase. Fomepizole 42-58 aldo-keto reductase family 1 member A1 Homo sapiens 167-188 2099148-4 1990 mu-Alcohol dehydrogenase stood out in high Km values for both ethanol (18 mM) and NAD+ (340 microM) as well as in high Ki value (320 microM) for 4-methylpyrazole, a competitive inhibitor for ethanol. Fomepizole 145-161 aldo-keto reductase family 1 member A1 Homo sapiens 3-24 35311442-2 2022 The treatment of patients with ethylene glycol poisoning includes competitively inhibiting alcohol dehydrogenase with ethanol or fomepizole to prevent the formation of toxic metabolites, and extracorporeal treatments such as hemodialysis to remove ethylene glycol and its metabolites. Fomepizole 129-139 aldo-keto reductase family 1 member A1 Homo sapiens 91-112