PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18155253-3 2008 OGG1, NEIL1 and MUTYH are all involved in the repair and prevention of 8-oxodG-derived mutations and may be up-regulated by oxidative stress. 8-ohdg 71-78 mutY DNA glycosylase Homo sapiens 16-21 18776649-0 2008 OGG1, MYH and MTH1 gene variants identified in gastric cancer patients exhibiting both 8-hydroxy-2"-deoxyguanosine accumulation and low inflammatory cell infiltration in their gastric mucosa. 8-ohdg 87-114 mutY DNA glycosylase Homo sapiens 6-9 17161978-3 2007 MUTYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2"-deoxyguanosine, one of the most stable products of oxidative DNA damage. 8-ohdg 105-140 mutY DNA glycosylase Homo sapiens 0-5 12628248-2 2003 The Escherichia coli adenine glycosylase MutY and its human homolog (hMYH) play an important role in the prevention of mutations associated with OG by removing misincorporated adenine residues from OG:A mismatches. 8-ohdg 145-147 mutY DNA glycosylase Homo sapiens 69-73 26338705-8 2015 In particular, MUTYH activity on 8-oxodG:rA mispairs is fully inhibited, although its binding capacity is retained. 8-ohdg 33-40 mutY DNA glycosylase Homo sapiens 15-20 32183600-5 2020 Multiple distinct mechanisms work together to decrease the genomic level of 8-OHdG through the enzymatic activities of Mutyh, Ogg1 and Mth1. 8-ohdg 76-82 mutY DNA glycosylase Homo sapiens 119-124 30008864-1 2018 Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1). 8-ohdg 53-80 mutY DNA glycosylase Homo sapiens 237-242 30008864-1 2018 Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1). 8-ohdg 82-88 mutY DNA glycosylase Homo sapiens 237-242 30008864-1 2018 Oxidative stress, demonstrated by an accumulation of 8-hydroxy-2"-deoxyguanosine (8-OHdG), results in DNA damage, which is normally repaired by base excision repair enzymes including 8-OHdG DNA glycosylase (OGG1) and human MutY homolog (MUTYH), in addition to nucleotide pool sanitizing enzymes including MutT Homolog 1 (MTH1). 8-ohdg 183-189 mutY DNA glycosylase Homo sapiens 237-242 32821650-3 2020 MUTYH functionally cooperates with OGG1 that eliminates 8-oxodG derived from excessive reactive oxygen species production. 8-ohdg 56-63 mutY DNA glycosylase Homo sapiens 0-5 27481934-2 2016 In order to maintain genomic integrity, post-replicative 8-oxo-dG:dA mispairs are removed through DNA polymerase lambda (Pol lambda)-dependent MUTYH-initiated base excision repair (BER). 8-ohdg 57-65 mutY DNA glycosylase Homo sapiens 143-148 23507534-1 2013 MUTYH, a human ortholog of MutY, is a post-replicative DNA glycosylase, highly conserved throughout evolution, involved in the correction of mismatches resulting from a faulty replication of the oxidized base 8-hydroxyguanine (8-oxodG). 8-ohdg 227-234 mutY DNA glycosylase Homo sapiens 0-5 24569162-1 2014 The MUTYH DNA glycosylase counteracts mutagenesis by removing adenine misincorporated opposite DNA 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG). 8-ohdg 99-134 mutY DNA glycosylase Homo sapiens 4-9 24569162-1 2014 The MUTYH DNA glycosylase counteracts mutagenesis by removing adenine misincorporated opposite DNA 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxodG). 8-ohdg 136-143 mutY DNA glycosylase Homo sapiens 4-9 23936466-2 2013 The polymorphic AluYb8 insertion in the 15(th) intron of the MUTYH gene (AluYb8MUTYH) has been shown to associate with an aggregated 8-hydroxy-2"-deoxyguanosine (8-OH-dG) lesion in genomic DNA and to serve as a risk factor for age-related diseases. 8-ohdg 133-160 mutY DNA glycosylase Homo sapiens 61-66 23936466-2 2013 The polymorphic AluYb8 insertion in the 15(th) intron of the MUTYH gene (AluYb8MUTYH) has been shown to associate with an aggregated 8-hydroxy-2"-deoxyguanosine (8-OH-dG) lesion in genomic DNA and to serve as a risk factor for age-related diseases. 8-ohdg 162-169 mutY DNA glycosylase Homo sapiens 61-66 23507534-2 2013 In particular removal of adenine from A:8-oxodG mispairs by MUTYH activity is followed by error-free base excision repair (BER) events, leading to the formation of C:8-oxodG base pairs. 8-ohdg 40-47 mutY DNA glycosylase Homo sapiens 60-65 23507534-2 2013 In particular removal of adenine from A:8-oxodG mispairs by MUTYH activity is followed by error-free base excision repair (BER) events, leading to the formation of C:8-oxodG base pairs. 8-ohdg 166-173 mutY DNA glycosylase Homo sapiens 60-65 22720119-5 2012 The average 8-OHdG/10(6) dG value was significantly higher in patients with the OGG1 c.977G, MUTYH c.972G or AluYb8MUTYH alleles (P < 0.001 via ANOVA). 8-ohdg 12-18 mutY DNA glycosylase Homo sapiens 93-98 22641385-1 2012 The base excision repair gene MUTYH encodes glycosylase which removes adenine residues mispaired with 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-OHG). 8-ohdg 114-149 mutY DNA glycosylase Homo sapiens 30-35 22641385-1 2012 The base excision repair gene MUTYH encodes glycosylase which removes adenine residues mispaired with 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-OHG). 8-ohdg 151-156 mutY DNA glycosylase Homo sapiens 30-35 22444586-1 2012 MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with the oxidatively modified form of deoxyguanosine, 8-oxo-7,8-dihydro-2"-deoxyguanosine. 8-ohdg 147-182 mutY DNA glycosylase Homo sapiens 29-34 22720119-6 2012 Further analysis showed that combination of MUTYH c.972GG with OGG1 c.977GG or AluYb8MUTYH increased both the risk for ESRD and leukocyte DNA 8-OHdG levels in HD patients. 8-ohdg 142-148 mutY DNA glycosylase Homo sapiens 44-49 21112374-0 2011 AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population. 8-ohdg 59-65 mutY DNA glycosylase Homo sapiens 24-29 20724227-2 2010 MUTYH is a DNA glycosylase that removes adenine (A) misinserted opposite 8-oxo-7,8-dihydro-2"-deoxyguanosine (OG). 8-ohdg 73-108 mutY DNA glycosylase Homo sapiens 0-5 19932167-1 2010 We describe a common mutation of the MYH gene, which is involved in the repair of oxidative damage to DNA, and its relationship to age, levels of 8-OHdG, and circulating levels of interleukin-1. 8-ohdg 146-152 mutY DNA glycosylase Homo sapiens 37-40 19932167-5 2010 Because the MYH gene is involved in DNA repair we assessed whether homozygous carriage of this gene was associated with increased levels of 8-OHdG in the leukocytic DNA of carriers. 8-ohdg 140-146 mutY DNA glycosylase Homo sapiens 12-15