PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21750471-9 2011 There was a 1.9-fold (P<0.003) decrease in the formation of both isomers of the olanzapine-10-N-glucuronide, a 2.7-fold (P<0.0001) decrease in olanzapine-4"-N-glucuronide formation, and a 2.1-fold (P=0.0002) decrease in the overall olanzapine glucuronide formation in HLM with at least one UGT2B10*2 allele. Glucuronides 99-110 UDP glucuronosyltransferase family 2 member B10 Homo sapiens 296-303 19786624-8 2010 In smokers with a UGT2B10 Tyr67 allele, glucuronide conjugation of nicotine and cotinine was decreased by 20% compared with smokers without this allele. Glucuronides 40-51 UDP glucuronosyltransferase family 2 member B10 Homo sapiens 18-25 18300939-6 2008 A novel polymorphism resulting in an aspartic acid to tyrosine amino acid change at codon 67 of the UGT2B10 complementary DNA was identified exclusively in subjects with a haplotype C. Unlike the high activity observed in microsomes from HEK293 cells over expressing the wild-type UGT2B10(67Asp) variant, microsomes from HEK293 cells over expressing the UGT2B10(67Tyr) variant exhibited minimal glucuronide formation activity against NNAL or other tobacco-specific nitrosamines tested in vitro. Glucuronides 395-406 UDP glucuronosyltransferase family 2 member B10 Homo sapiens 100-107