PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31740989-5 2020 In agreement with our previous genotyping data, the genetic polymorphism of uridine 5"-diphospho-glucuronosyltransferase (UGT)1A1*6, which affects the glucuronidation activity and circulating glucuronic acid level was identified as one of the determinants of MMI-induced hepatotoxicity. Glucuronic Acid 192-207 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 122-129 8467709-2 1993 The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. Glucuronic Acid 76-91 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 108-114 29357726-7 2019 TSI could be reduced to a relatively unstable hydroquinone intermediate by NAD(P)H: quinone oxidoreductase 1 (NQO1), and then immediately conjugated with glucuronic acid by a panel of UGTs, especially UGT1A9, UGT1A1 and UGT1A8. Glucuronic Acid 154-169 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 209-215 20668247-1 2010 Bilirubin, an end product of heme catabolism, is primarily eliminated via glucuronic acid conjugation by UGT1A1. Glucuronic Acid 74-89 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 105-111 28263463-7 2017 The data show that this drug inhibits the enzyme UDP-glucuronosyl transferase-1A1, responsible for conjugating bilirubin with glucuronic acid. Glucuronic Acid 126-141 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 49-81 23089802-1 2013 Human UDP-glucuronosyltransferase (UGT) 1A1 is the enzyme that detoxifies neurotoxic bilirubin by conjugating it with glucuronic acid. Glucuronic Acid 118-133 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 6-43 21413806-4 2011 UGT 1A1 equally glucuronidated 3-O (glucuronic acid substituted at C-3 hydroxyl group), 7-O, and 4"-O, whereas UGTs 1A8 and 1A9 preferably glucuronidated only 3-O and 7-O positions. Glucuronic Acid 36-51 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 0-7 19343046-3 2009 UGT1A1 catalyzes the conjugation of bilirubin with glucuronic acid, thus enhancing bilirubin elimination. Glucuronic Acid 51-66 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 0-6 11906189-1 2002 The UDP-glucuronosyltransferase UGT1A1 plays a critical role in the detoxification of potentially neurotoxic bilirubin by conjugating it with glucuronic acid. Glucuronic Acid 142-157 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 32-38 17952380-3 2008 Unconjugated bilirubin is conjugated with glucuronic acid through the reaction of uridine 5"-diphosphate-glucuronosyl transferase 1A1 (UGT1A1). Glucuronic Acid 42-57 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 82-133 17952380-3 2008 Unconjugated bilirubin is conjugated with glucuronic acid through the reaction of uridine 5"-diphosphate-glucuronosyl transferase 1A1 (UGT1A1). Glucuronic Acid 42-57 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 135-141 16139098-4 2005 Further investigation identified multiple UGT isoforms to be responsible for catalyzing the addition of glucuronic acid to ethanol, with UGT1A1 and 2B7 being the two most prevalent isoforms. Glucuronic Acid 104-119 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 137-143 16399345-1 2005 Human UDP-glucuronosyltransferase (UGT) 1A1 is the enzyme that detoxifies neurotoxic bilirubin by conjugating it with glucuronic acid. Glucuronic Acid 118-133 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 6-43 18172616-1 2008 Human UDP-glucuronosyltransferase (UGT)1A1 is a critical enzyme responsible for detoxification and metabolism of endogenous and exogenous lipophilic compounds, such as potentially neurotoxic bilirubin and the anticancer drug irinotecan SN-38, via conjugation with glucuronic acid. Glucuronic Acid 264-279 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 6-42 12618960-7 2003 UGT1A1 catalyzes the conjugation of bilirubin with glucuronic acid and thus enhances bilirubin elimination; therefore, it is an important candidate gene for serum bilirubin. Glucuronic Acid 51-66 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 0-6 11343253-1 2001 The UDP-glucuronosyltransferase, UGT1A1, is the critical enzyme responsible for detoxification of the potentially neurotoxic bilirubin by conjugating it with glucuronic acid. Glucuronic Acid 158-173 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 33-39