PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33431858-0	2021	ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway.	Taurocholic Acid	25-41	ATP binding cassette subfamily A member 8	Homo sapiens	0-5	
33431858-5	2021	Moreover, our results showed that treatment with taurocholic acid (TCA), an endogenous substrate of ABCA8, also induced GEM insensitivity in PC cells.	Taurocholic Acid	49-65	ATP binding cassette subfamily A member 8	Homo sapiens	100-105	
33431858-5	2021	Moreover, our results showed that treatment with taurocholic acid (TCA), an endogenous substrate of ABCA8, also induced GEM insensitivity in PC cells.	Taurocholic Acid	67-70	ATP binding cassette subfamily A member 8	Homo sapiens	100-105	
33431858-6	2021	We further demonstrated that ABCA8 mediates the efflux of TCA out of PC cells, and that extracellular TCA activates extracellular signal-regulated kinase (ERK) signaling via the sphingosine 1-phosphate receptor 2 (S1PR2), which is responsible for ABCA8-induced GEM ineffectiveness.	Taurocholic Acid	58-61	ATP binding cassette subfamily A member 8	Homo sapiens	29-34	
33431858-6	2021	We further demonstrated that ABCA8 mediates the efflux of TCA out of PC cells, and that extracellular TCA activates extracellular signal-regulated kinase (ERK) signaling via the sphingosine 1-phosphate receptor 2 (S1PR2), which is responsible for ABCA8-induced GEM ineffectiveness.	Taurocholic Acid	102-105	ATP binding cassette subfamily A member 8	Homo sapiens	247-252	
33431858-7	2021	Together, these findings reveal a novel TCA-related mechanism of ABCA subfamily transporter-mediated chemoresistance that goes beyond the role of a drug pump and suggest ABCA8 or the TCA-S1RP2-ERK pathway as potential targets for improving the effectiveness of and overcoming the resistance to chemotherapy in PC.	Taurocholic Acid	40-43	ATP binding cassette subfamily A member 8	Homo sapiens	170-175