PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33431858-0 2021 ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway. Taurocholic Acid 25-41 ATP binding cassette subfamily A member 8 Homo sapiens 0-5 33431858-5 2021 Moreover, our results showed that treatment with taurocholic acid (TCA), an endogenous substrate of ABCA8, also induced GEM insensitivity in PC cells. Taurocholic Acid 49-65 ATP binding cassette subfamily A member 8 Homo sapiens 100-105 33431858-5 2021 Moreover, our results showed that treatment with taurocholic acid (TCA), an endogenous substrate of ABCA8, also induced GEM insensitivity in PC cells. Taurocholic Acid 67-70 ATP binding cassette subfamily A member 8 Homo sapiens 100-105 33431858-6 2021 We further demonstrated that ABCA8 mediates the efflux of TCA out of PC cells, and that extracellular TCA activates extracellular signal-regulated kinase (ERK) signaling via the sphingosine 1-phosphate receptor 2 (S1PR2), which is responsible for ABCA8-induced GEM ineffectiveness. Taurocholic Acid 58-61 ATP binding cassette subfamily A member 8 Homo sapiens 29-34 33431858-6 2021 We further demonstrated that ABCA8 mediates the efflux of TCA out of PC cells, and that extracellular TCA activates extracellular signal-regulated kinase (ERK) signaling via the sphingosine 1-phosphate receptor 2 (S1PR2), which is responsible for ABCA8-induced GEM ineffectiveness. Taurocholic Acid 102-105 ATP binding cassette subfamily A member 8 Homo sapiens 247-252 33431858-7 2021 Together, these findings reveal a novel TCA-related mechanism of ABCA subfamily transporter-mediated chemoresistance that goes beyond the role of a drug pump and suggest ABCA8 or the TCA-S1RP2-ERK pathway as potential targets for improving the effectiveness of and overcoming the resistance to chemotherapy in PC. Taurocholic Acid 40-43 ATP binding cassette subfamily A member 8 Homo sapiens 170-175