PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17038509-2 2007 Taurocholate flux was measured across human apical sodium-dependent bile acid transporter (hASBT)-Madin-Darby canine kidney monolayers on different occasions and kinetic parameters estimated with and without considering ABL. Taurocholic Acid 0-12 solute carrier family 10 member 2 Homo sapiens 91-96 24317697-6 2014 The crystal structure of an ASBT homologue from Neisseria meningitidis (ASBT(NM)) in detergent was reported recently, showing the protein in an inward-open conformation bound to two Na(+) and a taurocholic acid. Taurocholic Acid 194-210 solute carrier family 10 member 2 Homo sapiens 28-32 24317697-6 2014 The crystal structure of an ASBT homologue from Neisseria meningitidis (ASBT(NM)) in detergent was reported recently, showing the protein in an inward-open conformation bound to two Na(+) and a taurocholic acid. Taurocholic Acid 194-210 solute carrier family 10 member 2 Homo sapiens 72-76 21649730-9 2011 A novel variant, 790A>G, was also shown to exhibit near complete loss of taurocholate transport, similar to the previously identified ASBT missense mutations. Taurocholic Acid 76-88 solute carrier family 10 member 2 Homo sapiens 137-141 15832499-3 2004 The affinity of the prodrug for hASBT was determined through inhibition of taurocholate uptake by COS-7 cells transfected with hASBT (hASBT-COS). Taurocholic Acid 75-87 solute carrier family 10 member 2 Homo sapiens 32-37 16078136-6 2005 Western blot confirmed the expression of the recombinant hASBT; functionality was characterized using taurocholic acid. Taurocholic Acid 102-118 solute carrier family 10 member 2 Homo sapiens 57-62 16078136-7 2005 RESULTS: In the selected clone, hASBT-mediated taurocholate permeability across hASBT-MDCK monolayers was almost 25-fold higher with sodium, than without sodium where hASBT is not functional. Taurocholic Acid 47-59 solute carrier family 10 member 2 Homo sapiens 32-37 16078136-7 2005 RESULTS: In the selected clone, hASBT-mediated taurocholate permeability across hASBT-MDCK monolayers was almost 25-fold higher with sodium, than without sodium where hASBT is not functional. Taurocholic Acid 47-59 solute carrier family 10 member 2 Homo sapiens 80-85 16078136-7 2005 RESULTS: In the selected clone, hASBT-mediated taurocholate permeability across hASBT-MDCK monolayers was almost 25-fold higher with sodium, than without sodium where hASBT is not functional. Taurocholic Acid 47-59 solute carrier family 10 member 2 Homo sapiens 80-85 16078136-8 2005 In the presence of sodium, taurocholate and mannitol permeabilities were 23.0x10(-6) cm/sec and 2.60x10(-6) cm/s, respectively, indicating high hASBT functionality and monolayer integrity. Taurocholic Acid 27-39 solute carrier family 10 member 2 Homo sapiens 144-149 16078136-10 2005 Taurocholate uptake and inhibition kinetic parameters from hASBT-MDCK were similar to those obtained from hASBT-COS7 model, confirming hASBT functionality in hASBT-MDCK. Taurocholic Acid 0-12 solute carrier family 10 member 2 Homo sapiens 59-64 34346218-3 2021 ASBT is responsible for most of the taurocholic acid (TC) uptake in Caco-2 cells. Taurocholic Acid 36-52 solute carrier family 10 member 2 Homo sapiens 0-4 11230727-3 2001 Expression of the apical sodium-dependent bile acid transporter (ASBT) and of the organic anion transporting polypeptide (OATP-A) was detected and associated with sodium-dependent and sodium-independent [(3)H]taurocholate uptake in BEC. Taurocholic Acid 209-221 solute carrier family 10 member 2 Homo sapiens 18-63 11230727-3 2001 Expression of the apical sodium-dependent bile acid transporter (ASBT) and of the organic anion transporting polypeptide (OATP-A) was detected and associated with sodium-dependent and sodium-independent [(3)H]taurocholate uptake in BEC. Taurocholic Acid 209-221 solute carrier family 10 member 2 Homo sapiens 65-69 34346218-3 2021 ASBT is responsible for most of the taurocholic acid (TC) uptake in Caco-2 cells. Taurocholic Acid 54-56 solute carrier family 10 member 2 Homo sapiens 0-4 34346218-5 2021 The results from the TC uptake assay using N-acetylcysteine suggested that the inhibitory effect of TF2A and TF2B was attributed to the oxidization of their benzotropolone rings and their covalent bonding with ASBT"s cysteine. Taurocholic Acid 21-23 solute carrier family 10 member 2 Homo sapiens 210-214 34346218-6 2021 TC uptake was reduced in the COS-7 cells expressing recombinant ASBT whose cysteine residues were mutated to alanine. Taurocholic Acid 0-2 solute carrier family 10 member 2 Homo sapiens 64-68