PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 4729973-3 1973 Taurocholate and taurodeoxycholate, but not taurochenodeoxycholate, inhibited cholesterol 7alpha-hydroxylase. Taurocholic Acid 0-12 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 78-108 446480-10 1979 The change in cholesterol 7 alpha-hydroxylase activity seen on incubation of the cells was not affected by including in the incubation medium additional nutrients such as amino acids, the glucocorticoid cortisol, phospholipid dispersions, or sodium taurocholate. Taurocholic Acid 242-261 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 14-45 11278771-8 2001 Overexpression of dominant-negative JNK1 or a transactivating domain mutant of c-Jun significantly blocked the ability of TCA to down-regulate CYP7A1 mRNA. Taurocholic Acid 122-125 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 143-149 12759897-12 2003 Intraduodenal infusion of TCA to rats with biliary diversion decreased SA of both CYP7B1 ( downward arrow 29%; P <.001) and CYP7A1 ( downward arrow 46%; P <.01). Taurocholic Acid 26-29 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 127-133 11278771-9 2001 In contrast, overexpression of wild-type c-Jun (c-Jun(wt)) enhanced the repression of CYP7A1 by TCA. Taurocholic Acid 96-99 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 86-92 9458268-1 1997 The feedback repression of cholesterol 7alpha-hydroxylase transcriptional activity and mRNA levels by taurocholate (TCA) occurs via a protein kinase C (PKC)-dependent signal. Taurocholic Acid 102-114 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 27-57 9458268-1 1997 The feedback repression of cholesterol 7alpha-hydroxylase transcriptional activity and mRNA levels by taurocholate (TCA) occurs via a protein kinase C (PKC)-dependent signal. Taurocholic Acid 116-119 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 27-57 7666012-1 1995 Inhibitors of protein kinases were screened for the ability to prevent the repression of cholesterol 7 alpha-hydroxylase mRNA by taurocholate in primary cultures of adult rat hepatocytes. Taurocholic Acid 129-141 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 89-120 8770045-1 1996 We have recently shown that taurocholate (TCA) represses the transcriptional activity of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme of the bile acid biosynthetic pathway, through a protein kinase C (PKC)-dependent mechanism in primary cultures of rat hepatocytes. Taurocholic Acid 28-40 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 89-120 8770045-1 1996 We have recently shown that taurocholate (TCA) represses the transcriptional activity of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme of the bile acid biosynthetic pathway, through a protein kinase C (PKC)-dependent mechanism in primary cultures of rat hepatocytes. Taurocholic Acid 42-45 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 89-120 8770045-10 1996 The calcium-independent PKC isoforms may mediate the repression of cholesterol 7 alpha-hydroxylase mRNA by TCA. Taurocholic Acid 107-110 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 67-98 7666012-2 1995 The addition of taurocholate (25 microM) for 6 h decreased cholesterol 7 alpha-hydroxylase mRNA by 64 +/- 3%. Taurocholic Acid 16-28 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 59-90 7666012-4 1995 Protein kinase C activation with phorbol 12-myristate, 13-acetate (100 nM) decreased cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by 71 +/- 5% and 60 +/- 16%, respectively, within 3 h. mRNA levels recovered to control levels by 18-24 h, however, consistent with downregulation of protein kinase C. Furthermore, after depletion of protein kinase C with a 24-h preincubation with phorbol diesters, taurocholate (25 microM) repressed cholesterol 7 alpha-hydroxylase mRNA by only 14 +/- 17%. Taurocholic Acid 417-429 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 85-116 8457195-2 1993 Addition of taurocholic acid, the most predominant bile acid in rat bile, to the culture medium suppressed cholesterol 7 alpha-hydroxylase activity and mRNA time- and dose-dependently. Taurocholic Acid 12-28 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 107-138 8314765-2 1993 Taurocholate and taurodeoxycholate (50 microM) repressed cholesterol 7 alpha-hydroxylase mRNA to 44 +/- 9 and 52 +/- 4%, respectively, of control values. Taurocholic Acid 0-12 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 57-88 8314765-6 1993 Cholesterol 7 alpha-hydroxylase specific activity was decreased by taurocholate or taurodeoxycholate (50 microM) to 26 +/- 9 and 56 +/- 3% of control, respectively; its transcriptional activity was repressed to 52 +/- 5% of control by taurocholate (50 microM). Taurocholic Acid 67-79 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 8314765-6 1993 Cholesterol 7 alpha-hydroxylase specific activity was decreased by taurocholate or taurodeoxycholate (50 microM) to 26 +/- 9 and 56 +/- 3% of control, respectively; its transcriptional activity was repressed to 52 +/- 5% of control by taurocholate (50 microM). Taurocholic Acid 235-247 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 7835596-0 1995 Failure of intravenous infusion of taurocholate to down-regulate cholesterol 7 alpha-hydroxylase in rats with biliary fistulas. Taurocholic Acid 35-47 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 65-96 7835596-1 1995 BACKGROUND/AIMS: The decrease in cholesterol 7 alpha-hydroxylase induced by intraduodenal infusion of taurocholate in bile fistula rats may be indirect, i.e., mediated through release or absorption of an intestinal factor in response to the presence of bile salts in the intestine. Taurocholic Acid 102-114 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 33-64 7835596-2 1995 The aim of this study was to determine if negative feedback regulation of cholesterol 7 alpha-hydroxylase can be shown when equimolar concentrations of taurocholate are administered intravenously, thus bypassing the intestine. Taurocholic Acid 152-164 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 74-105 7835596-5 1995 RESULTS: Intraduodenally administered taurocholate significantly decreased HMG-CoA reductase and cholesterol 7 alpha-hydroxylase specific activity by more than 50% and cholesterol 7 alpha-hydroxylase steady-state messenger RNA levels and transcriptional activity by 50%-75%. Taurocholic Acid 38-50 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 97-128 7835596-7 1995 CONCLUSIONS: Passage of taurocholate through the intestine strongly potentiates negative feedback regulation of cholesterol 7 alpha-hydroxylase. Taurocholic Acid 24-36 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 112-143 7832767-9 1995 Assessment of the transcriptional activity of a number of genes involved in routing of cholesterol towards bile acids showed similar suppressive effects of taurocholate on expression of the sterol 27-hydroxylase and cholesterol 7 alpha-hydroxylase genes (-43% and -42% respectively), whereas expression of the lithocholic 6 beta-hydroxylase gene was not affected. Taurocholic Acid 156-168 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 216-247 8138269-1 1994 Cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in the bile acid synthesis pathway, is down-regulated by taurocholate by way of negative feedback control at the level of gene transcription. Taurocholic Acid 115-127 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 8457195-4 1993 Maximal suppression of cholesterol 7 alpha-hydroxylase mRNA (-91%) and enzyme activity (-89%) was observed after a 16 h incubation period with 50 microM taurocholic acid. Taurocholic Acid 153-169 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 23-54 8457195-6 1993 Mass production of bile acids (chenodeoxycholic acid and beta-muricholic acid) was inhibited to a similar extent as the cholesterol 7 alpha-hydroxylase when different concentrations of taurocholic acid were used, giving maximal inhibition (-81%) at 50 microM taurocholic acid. Taurocholic Acid 185-201 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 120-151 8457195-6 1993 Mass production of bile acids (chenodeoxycholic acid and beta-muricholic acid) was inhibited to a similar extent as the cholesterol 7 alpha-hydroxylase when different concentrations of taurocholic acid were used, giving maximal inhibition (-81%) at 50 microM taurocholic acid. Taurocholic Acid 259-275 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 120-151 8457195-7 1993 Glycocholic acid and unconjugated cholic acid were equally effective as taurocholic acid in suppressing cholesterol 7 alpha-hydroxylase mRNA. Taurocholic Acid 72-88 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 104-135 2318973-5 1990 When sodium taurocholate was infused at the rate of 27 mumol/100 g rat per h (equivalent to the hourly hepatic bile-acid flux), bile-acid synthesis decreased 82% and cholesterol 7 alpha-hydroxylase activity declined 78%. Taurocholic Acid 5-24 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 166-197 1431598-5 1992 Cholesterol 7 alpha-hydroxylase activity increased 4-fold with cholestyramine and 29% during cholesterol feeding, but decreased 64% with taurocholate. Taurocholic Acid 137-149 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 1431598-6 1992 Cholesterol 7 alpha-hydroxylase mRNA levels rose 150% and 50% with cholestyramine and cholesterol feeding, respectively, but decreased 73% with taurocholate. Taurocholic Acid 144-156 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 1431598-7 1992 The administration of cholesterol together with taurocholate prevented the decline in cholesterol 7 alpha-hydroxylase mRNA levels, but inhibition of enzyme activity persisted (-76%). Taurocholic Acid 48-60 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 86-117 1619360-2 1992 Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate. Taurocholic Acid 49-61 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 14-45 1619360-3 1992 Taurocholate, a relatively hydrophobic bile salt, is a potent down-regulator of HMG-CoA reductase and cholesterol 7 alpha-hydroxylase (C7 alpha H), the rate-determining enzymes of the cholesterol and bile acid biosynthetic pathways, respectively. Taurocholic Acid 0-12 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 102-133 1993648-3 1991 Cholesterol 7 alpha-hydroxylase activity increased 6-fold, enzyme mass 34%, and catalytic efficiency 5-fold after interruption of the enterohepatic circulation for 48 h. When taurocholate was infused to the bile acid-depleted animals at a rate equivalent to the hepatic bile acid flux (27 mumol/100-g rat/h), cholesterol 7 alpha-hydroxylase activity and enzyme mass declined 60 and 61%, respectively. Taurocholic Acid 175-187 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 1993648-3 1991 Cholesterol 7 alpha-hydroxylase activity increased 6-fold, enzyme mass 34%, and catalytic efficiency 5-fold after interruption of the enterohepatic circulation for 48 h. When taurocholate was infused to the bile acid-depleted animals at a rate equivalent to the hepatic bile acid flux (27 mumol/100-g rat/h), cholesterol 7 alpha-hydroxylase activity and enzyme mass declined 60 and 61%, respectively. Taurocholic Acid 175-187 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 309-340 1993648-6 1991 However, when taurocholate was infused together with mevalonolactone, cholesterol 7 alpha-hydroxylase activity and catalytic efficiency were markedly depressed while enzyme mass did not change as compared with bile acid-depleted rats. Taurocholic Acid 14-26 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 70-101 1431598-0 1992 Differing effects of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase activities and mRNA levels in the rat. Taurocholic Acid 37-49 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 96-127 1619360-5 1992 It is therefore conceivable that taurocholate may suppress cholesterol 7 alpha-hydroxylase primarily by down-regulating the activity of HMG-CoA reductase. Taurocholic Acid 33-45 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 59-90 1619360-9 1992 When rats with biliary diversion were infused intraduodenally with taurocholate, the specific activities of HMG-CoA reductase and cholesterol 7 alpha-hydroxylase activities decreased by 75% (P less than 0.001) and 73% (P less than 0.001), respectively. Taurocholic Acid 67-79 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 130-161 1619360-10 1992 Cholesterol 7 alpha-hydroxylase mass, mRNA, and transcriptional activity decreased after intraduodenal infusion of taurocholate to levels similar to those of rats with an intact enterohepatic circulation. Taurocholic Acid 115-127 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 0-31 1619360-12 1992 These data provide evidence that taurocholate represses cholesterol 7 alpha-hydroxylase at the level of gene transcription, and not via down-regulation of HMG-CoA reductase. Taurocholic Acid 33-45 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 56-87 1995604-0 1991 Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat. Taurocholic Acid 83-95 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 14-45 1995604-5 1991 Intraduodenal infusion of taurocholate at a rate of 36 mumol/100 g/h for 48 h in CBD rats caused a significant (p less than 0.05) decrease (64%) in cholesterol 7 alpha-hydroxylase-specific activity, mass (72%), steady-state mRNA levels (74%), and transcriptional activity (57%) as compared to CBD controls. Taurocholic Acid 26-38 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 148-179