PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34664036-7 2021 Maintaining proper blood glucose levels using oral antidiabetic drugs like Metformin reduced the detrimental effects of COVID-19 by different possible mechanisms such as Metformin-mediated anti-inflammatory and immunomodulatory activities; effect on viral entry and ACE2 stability; inhibition of virus infection; alters virus survival and endosomal pH; mTOR inhibition; and influence on gut microbiota. Metformin 75-84 angiotensin converting enzyme 2 Homo sapiens 266-270 33815295-8 2021 Decreasing insulin resistance, reduction of some inflammatory cytokines like IL-6 and TNF-alpha, modulation of angiotensin-converting enzyme 2 (ACE2) receptor, and improving neutrophil to lymphocyte ratio are some of the potential mechanisms of metformin in COVID-19 patients with DM. Metformin 245-254 angiotensin converting enzyme 2 Homo sapiens 111-142 34972763-2 2021 Medications that affect ACE2 expression or function such as angiotensin receptor blockers (ARBs) and ACE inhibitors (ACE-I) and metformin have the potential to counter the dysregulation of ACE2 by the virus and protect against viral injury. Metformin 128-137 angiotensin converting enzyme 2 Homo sapiens 24-28 34972763-2 2021 Medications that affect ACE2 expression or function such as angiotensin receptor blockers (ARBs) and ACE inhibitors (ACE-I) and metformin have the potential to counter the dysregulation of ACE2 by the virus and protect against viral injury. Metformin 128-137 angiotensin converting enzyme 2 Homo sapiens 189-193 34646263-12 2021 We observed that the antidiabetic biguanide metformin, a putative anti-inflammatory agent, also upregulates ACE2 expression in Calu-3 and endothelial cells. Metformin 44-53 angiotensin converting enzyme 2 Homo sapiens 108-112 32838195-4 2020 Firstly, AMPK mediated phosphorylation of ACE-2 by metformin as well as the drug"s alkaline properties may interrupt the natural disease progression. Metformin 51-60 angiotensin converting enzyme 2 Homo sapiens 42-47 34966196-1 2021 Introduction: Metformin has known mechanistic benefits on COVID-19 infection due to its anti-inflammatory effects and its action on the ACE2 receptor. Metformin 14-23 angiotensin converting enzyme 2 Homo sapiens 136-140 34983356-9 2022 Metformin and statins through immunomodulatory activities, Orlistat by reducing viral replication, and thiazolidinediones by upregulating ACE2 expression have potential beneficial effects against COVID-19. Metformin 0-9 angiotensin converting enzyme 2 Homo sapiens 138-142 33471718-2 2020 Metformin increases the expression of angiotensin converting enzyme 2, a known receptor for severe acute respiratory syndrome coronavirus 2. Metformin 0-9 angiotensin converting enzyme 2 Homo sapiens 38-69 33081905-12 2020 The possible mechanism is that metformin could inhibit cytokine storm via suppressing interleukin-6 (IL-6) signaling, prevent the process of lung fibrosis, suppress endocytosis, thereby elevating angiotensin converting enzyme 2 (ACE2) expression. Metformin 31-40 angiotensin converting enzyme 2 Homo sapiens 196-227 33081905-12 2020 The possible mechanism is that metformin could inhibit cytokine storm via suppressing interleukin-6 (IL-6) signaling, prevent the process of lung fibrosis, suppress endocytosis, thereby elevating angiotensin converting enzyme 2 (ACE2) expression. Metformin 31-40 angiotensin converting enzyme 2 Homo sapiens 229-233 35370738-7 2022 Modulation by metformin of the cell-surface ACE2 protein (a key binding target for SARS-CoV 2 spike protein) via the AMP kinase pathway may be involved. Metformin 14-23 angiotensin converting enzyme 2 Homo sapiens 44-48 34057870-6 2021 Hence, regulatory effects of metformin on membranous ACE2, and DPP4 can modulate immune reaction against Sars-cov2. Metformin 29-38 angiotensin converting enzyme 2 Homo sapiens 53-57 32818905-6 2020 Metformin is a widely available anti-diabetic agent that has an excellent safety profile, and clinical and preclinical data suggest metformin may offer cardiopulmonary protection in COVID-19 via enhanced ACE2 expression. Metformin 0-9 angiotensin converting enzyme 2 Homo sapiens 204-208 32818905-6 2020 Metformin is a widely available anti-diabetic agent that has an excellent safety profile, and clinical and preclinical data suggest metformin may offer cardiopulmonary protection in COVID-19 via enhanced ACE2 expression. Metformin 132-141 angiotensin converting enzyme 2 Homo sapiens 204-208 32685191-6 2020 There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D. Metformin 107-116 angiotensin converting enzyme 2 Homo sapiens 72-76