PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34664036-7	2021	Maintaining proper blood glucose levels using oral antidiabetic drugs like Metformin reduced the detrimental effects of COVID-19 by different possible mechanisms such as Metformin-mediated anti-inflammatory and immunomodulatory activities; effect on viral entry and ACE2 stability; inhibition of virus infection; alters virus survival and endosomal pH; mTOR inhibition; and influence on gut microbiota.	Metformin	75-84	angiotensin converting enzyme 2	Homo sapiens	266-270	
33815295-8	2021	Decreasing insulin resistance, reduction of some inflammatory cytokines like IL-6 and TNF-alpha, modulation of angiotensin-converting enzyme 2 (ACE2) receptor, and improving neutrophil to lymphocyte ratio are some of the potential mechanisms of metformin in COVID-19 patients with DM.	Metformin	245-254	angiotensin converting enzyme 2	Homo sapiens	111-142	
34972763-2	2021	Medications that affect ACE2 expression or function such as angiotensin receptor blockers (ARBs) and ACE inhibitors (ACE-I) and metformin have the potential to counter the dysregulation of ACE2 by the virus and protect against viral injury.	Metformin	128-137	angiotensin converting enzyme 2	Homo sapiens	24-28	
34972763-2	2021	Medications that affect ACE2 expression or function such as angiotensin receptor blockers (ARBs) and ACE inhibitors (ACE-I) and metformin have the potential to counter the dysregulation of ACE2 by the virus and protect against viral injury.	Metformin	128-137	angiotensin converting enzyme 2	Homo sapiens	189-193	
34646263-12	2021	We observed that the antidiabetic biguanide metformin, a putative anti-inflammatory agent, also upregulates ACE2 expression in Calu-3 and endothelial cells.	Metformin	44-53	angiotensin converting enzyme 2	Homo sapiens	108-112	
32838195-4	2020	Firstly, AMPK mediated phosphorylation of ACE-2 by metformin as well as the drug"s alkaline properties may interrupt the natural disease progression.	Metformin	51-60	angiotensin converting enzyme 2	Homo sapiens	42-47	
34966196-1	2021	Introduction: Metformin has known mechanistic benefits on COVID-19 infection due to its anti-inflammatory effects and its action on the ACE2 receptor.	Metformin	14-23	angiotensin converting enzyme 2	Homo sapiens	136-140	
34983356-9	2022	Metformin and statins through immunomodulatory activities, Orlistat by reducing viral replication, and thiazolidinediones by upregulating ACE2 expression have potential beneficial effects against COVID-19.	Metformin	0-9	angiotensin converting enzyme 2	Homo sapiens	138-142	
33471718-2	2020	Metformin increases the expression of angiotensin converting enzyme 2, a known receptor for severe acute respiratory syndrome coronavirus 2.	Metformin	0-9	angiotensin converting enzyme 2	Homo sapiens	38-69	
33081905-12	2020	The possible mechanism is that metformin could inhibit cytokine storm via suppressing interleukin-6 (IL-6) signaling, prevent the process of lung fibrosis, suppress endocytosis, thereby elevating angiotensin converting enzyme 2 (ACE2) expression.	Metformin	31-40	angiotensin converting enzyme 2	Homo sapiens	196-227	
33081905-12	2020	The possible mechanism is that metformin could inhibit cytokine storm via suppressing interleukin-6 (IL-6) signaling, prevent the process of lung fibrosis, suppress endocytosis, thereby elevating angiotensin converting enzyme 2 (ACE2) expression.	Metformin	31-40	angiotensin converting enzyme 2	Homo sapiens	229-233	
35370738-7	2022	Modulation by metformin of the cell-surface ACE2 protein (a key binding target for SARS-CoV 2 spike protein) via the AMP kinase pathway may be involved.	Metformin	14-23	angiotensin converting enzyme 2	Homo sapiens	44-48	
34057870-6	2021	Hence, regulatory effects of metformin on membranous ACE2, and DPP4 can modulate immune reaction against Sars-cov2.	Metformin	29-38	angiotensin converting enzyme 2	Homo sapiens	53-57	
32818905-6	2020	Metformin is a widely available anti-diabetic agent that has an excellent safety profile, and clinical and preclinical data suggest metformin may offer cardiopulmonary protection in COVID-19 via enhanced ACE2 expression.	Metformin	0-9	angiotensin converting enzyme 2	Homo sapiens	204-208	
32818905-6	2020	Metformin is a widely available anti-diabetic agent that has an excellent safety profile, and clinical and preclinical data suggest metformin may offer cardiopulmonary protection in COVID-19 via enhanced ACE2 expression.	Metformin	132-141	angiotensin converting enzyme 2	Homo sapiens	204-208	
32685191-6	2020	There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D.	Metformin	107-116	angiotensin converting enzyme 2	Homo sapiens	72-76