PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34730825-9	2021	Metformin inhibited CpG- and IFN-alpha-induced glutamine uptake, mitochondrial functions and suppressed plasmablast differentiation.	Metformin	0-9	interferon alpha 1	Homo sapiens	29-38	
22493491-8	2012	Metformin inhibits PTP and improves IFNalpha response in insulin-resistant cells.	Metformin	0-9	interferon alpha 1	Homo sapiens	36-44	
31160534-3	2019	In this study, we report that in CD4+ T cells from human healthy controls and human systemic lupus erythematosus patients, metformin inhibits the transcription of IFN-stimulated genes (ISGs) after IFN-alpha treatment.	Metformin	123-132	interferon alpha 1	Homo sapiens	197-206	
32094377-0	2020	Metformin-induced suppression of IFN-alpha via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes.	Metformin	0-9	interferon alpha 1	Homo sapiens	33-42	
30971831-6	2019	Metformin treatment modified gene expression related to OS and the IFN-alpha signaling pathway.	Metformin	0-9	interferon alpha 1	Homo sapiens	67-76	
26245802-17	2015	We assessed the effect of metformin on down-regulating the NET mtDNA-PDC-IFNalpha pathway.	Metformin	26-35	interferon alpha 1	Homo sapiens	73-81	
26245802-18	2015	Metformin decreased PMA-induced NET formation and CpG-stimulated PDC IFNalpha generation.	Metformin	0-9	interferon alpha 1	Homo sapiens	69-77	
26245802-20	2015	CONCLUSION: Our findings establish a link between mtDNA in NETs, anti-mtDNA antibodies, and PDC IFNalpha pathogenesis in SLE, and highlight that specific strategies to down-regulate this pathway, such as treatment with metformin, may be new approaches to treat SLE.	Metformin	219-228	interferon alpha 1	Homo sapiens	96-104