PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32094377-0 2020 Metformin-induced suppression of IFN-alpha via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes. Metformin 0-9 interferon alpha 1 Homo sapiens 33-42 34730825-9 2021 Metformin inhibited CpG- and IFN-alpha-induced glutamine uptake, mitochondrial functions and suppressed plasmablast differentiation. Metformin 0-9 interferon alpha 1 Homo sapiens 29-38 31160534-3 2019 In this study, we report that in CD4+ T cells from human healthy controls and human systemic lupus erythematosus patients, metformin inhibits the transcription of IFN-stimulated genes (ISGs) after IFN-alpha treatment. Metformin 123-132 interferon alpha 1 Homo sapiens 197-206 26245802-17 2015 We assessed the effect of metformin on down-regulating the NET mtDNA-PDC-IFNalpha pathway. Metformin 26-35 interferon alpha 1 Homo sapiens 73-81 30971831-6 2019 Metformin treatment modified gene expression related to OS and the IFN-alpha signaling pathway. Metformin 0-9 interferon alpha 1 Homo sapiens 67-76 26245802-18 2015 Metformin decreased PMA-induced NET formation and CpG-stimulated PDC IFNalpha generation. Metformin 0-9 interferon alpha 1 Homo sapiens 69-77 26245802-20 2015 CONCLUSION: Our findings establish a link between mtDNA in NETs, anti-mtDNA antibodies, and PDC IFNalpha pathogenesis in SLE, and highlight that specific strategies to down-regulate this pathway, such as treatment with metformin, may be new approaches to treat SLE. Metformin 219-228 interferon alpha 1 Homo sapiens 96-104 22493491-8 2012 Metformin inhibits PTP and improves IFNalpha response in insulin-resistant cells. Metformin 0-9 interferon alpha 1 Homo sapiens 36-44