PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30307162-8	2018	Presence of metformin during 7-day culture with palmitate normalized the level of p-AMPK, p-EIF2alpha, CHOP and cleaved caspase 3 but significantly increased the level of sorcin.	Metformin	12-21	DNA damage inducible transcript 3	Homo sapiens	103-107	
31180536-7	2019	In addition, treatment with metformin increased the expression of Bip, CHOP and caspase-12 in vitro, activating endoplasmic reticulum (ER) stress.	Metformin	28-37	DNA damage inducible transcript 3	Homo sapiens	71-75	
31180536-10	2019	Finally, treatment with metformin inhibited thyroid cancer growth and increased the expression of Bip and CHOP in a TPC-1 cell xenograft model.	Metformin	24-33	DNA damage inducible transcript 3	Homo sapiens	106-110	
34164906-7	2021	The expression of Beclin1, VDAC1, LC3-II, CHOP and Bip was promoted in the cells received combinatorial treatment of metformin and MALAT1 knock-down.	Metformin	117-126	DNA damage inducible transcript 3	Homo sapiens	42-46	
22107872-5	2012	We found that metformin activates the PERK-ATF4 but not the ATF6 or IRE1-XBP1 branch in ERSS and leads to a strong upregulation of CHOP mRNA and protein.	Metformin	14-23	DNA damage inducible transcript 3	Homo sapiens	131-135	
28964970-5	2017	Mechanistically, metformin altered UPR activated by bortezomib, leading to a reduced expression of BiP, up-regulation of CHOP and down-regulation of Bcl-2.	Metformin	17-26	DNA damage inducible transcript 3	Homo sapiens	121-125	
24943970-0	2014	The relationship between anticancer effect of metformin and the transcriptional regulation of certain genes (CHOP, CAV-1, HO-1, SGK-1 and Par-4) on MCF-7 cell line.	Metformin	46-55	DNA damage inducible transcript 3	Homo sapiens	109-113	
24009772-3	2013	Metformin activated AMPK, down-regulated the unfolded protein response (UPR) demonstrated by significant decrease in the main UPR regulator GRP78, and led to UPR-mediated cell death via up-regulation of the ER stress/UPR cell death mediators IRE1alpha and CHOP.	Metformin	0-9	DNA damage inducible transcript 3	Homo sapiens	256-260	
24009772-4	2013	Using shRNA, we demonstrate that metformin-induced apoptosis is AMPK-dependent since AMPK knock-down rescued ALL cells, which correlated with down-regulation of IRE1alpha and CHOP and restoration of the UPR/GRP78 function.	Metformin	33-42	DNA damage inducible transcript 3	Homo sapiens	175-179	
23395946-6	2013	Furthermore, gene expression arrays revealed that metformin caused expression of stress markers DDIT3, CYP1A1,and GDF-15 and a concomitant reduction in PTGS1 expression.	Metformin	50-59	DNA damage inducible transcript 3	Homo sapiens	96-101	
26075749-5	2015	Meanwhile, the unfolded protein response regulator CHOP, p-eIF2alpha, calreticulin, GRP78 and ATP2A1, all of which are also considered as ER stress markers, are upregulated by metformin and miR-708-5p.	Metformin	176-185	DNA damage inducible transcript 3	Homo sapiens	51-55	
22107872-6	2012	Surprisingly, long-term induction of CHOP by metformin is not accompanied by apoptosis even though CHOP is regarded to be a mediator of ER-stress-induced apoptosis.	Metformin	45-54	DNA damage inducible transcript 3	Homo sapiens	37-41	
21895401-0	2011	Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.	Metformin	0-9	DNA damage inducible transcript 3	Homo sapiens	93-100	
21895401-4	2011	We also found that metformin treatment can activate AMP-activated protein kinase, JNK/p38 MAPK signaling pathway and caspases, as well as upregulate the expression of growth arrest and DNA damage inducible gene 153 (GADD153).	Metformin	19-28	DNA damage inducible transcript 3	Homo sapiens	167-214	
21895401-4	2011	We also found that metformin treatment can activate AMP-activated protein kinase, JNK/p38 MAPK signaling pathway and caspases, as well as upregulate the expression of growth arrest and DNA damage inducible gene 153 (GADD153).	Metformin	19-28	DNA damage inducible transcript 3	Homo sapiens	216-223	
21895401-5	2011	Either blockade of JNK/p38 MAPK pathway or knockdown of GADD153 gene abrogated the apoptosis-inducing effect of metformin.	Metformin	112-121	DNA damage inducible transcript 3	Homo sapiens	56-63	
21895401-6	2011	Taken together, our data suggest that metformin inhibits the growth of lung cancer cells and induces apoptosis through activating JNK/p38 MAPK pathway and GADD153.	Metformin	38-47	DNA damage inducible transcript 3	Homo sapiens	155-162	
20038265-5	2010	Metformin also blocked the induction of ER stress proteins (GRP78, Chop, Cleaved ATF-6, p-eIF2 alpha and XBP-1) and regulated serine phosphorylation of IRS-1.	Metformin	0-9	DNA damage inducible transcript 3	Homo sapiens	67-71