PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32312819-7 2020 Furthermore, glutamine deprivation, as well as the antimetabolic drugs 2-deoxyglucose and metformin, also promoted the release of IL-6 and IL-8. Metformin 90-99 C-X-C motif chemokine ligand 8 Homo sapiens 139-143 31840936-12 2020 Metformin or AICAR presence decreased spontaneous production of IL-6, IL-8 and MCP-1 in RA synovial explants and SFCs (n=5-7). Metformin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 70-74 30765814-0 2019 Metformin inhibits lithocholic acid-induced interleukin 8 upregulation in colorectal cancer cells by suppressing ROS production and NF-kB activity. Metformin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 44-57 31851935-3 2019 Metformin interrupts bidirectional signaling between tumor and mesothelial cells by blocking OvCa cell TGF-beta signaling and mesothelial cell production of CCL2 and IL-8. Metformin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 166-170 31851935-6 2019 Disruption of HIF1alpha-driven IL-8 signaling in mesothelial cells by metformin results in reduced OvCa invasion in an organotypic 3D model. Metformin 70-79 C-X-C motif chemokine ligand 8 Homo sapiens 31-35 31805999-0 2019 PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited by metformin. Metformin 108-117 C-X-C motif chemokine ligand 8 Homo sapiens 27-32 31703101-5 2019 Significantly elevated faecal sIgA levels during administration of metformin, and its correlation with the expression of genes associated with immune response (CXCR4, HLA-DQA1, MAP3K14, TNFRSF21, CCL4, ACVR1B, PF4, EPOR, CXCL8) supports a novel hypothesis of strong association between metformin and intestinal immune system, and for the first time provide evidence for altered RNA expression as a contributing mechanism of metformin"s action. Metformin 67-76 C-X-C motif chemokine ligand 8 Homo sapiens 221-226 31683341-0 2019 Treatment with Metformin and Combination of Metformin Plus Pioglitazone on Serum Levels of IL-6 and IL-8 in Polycystic Ovary Syndrome: A Randomized Clinical Trial. Metformin 44-53 C-X-C motif chemokine ligand 8 Homo sapiens 100-104 31683341-14 2019 Combination of metformin and pioglitazone therapy was more effective as compared to metformin alone in reducing the levels of IL-6 and IL-8 as well as insulin resistance in PCOS. Metformin 15-24 C-X-C motif chemokine ligand 8 Homo sapiens 135-139 31683341-14 2019 Combination of metformin and pioglitazone therapy was more effective as compared to metformin alone in reducing the levels of IL-6 and IL-8 as well as insulin resistance in PCOS. Metformin 84-93 C-X-C motif chemokine ligand 8 Homo sapiens 135-139 30765814-2 2019 In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells. Metformin 52-61 C-X-C motif chemokine ligand 8 Homo sapiens 65-78 30765814-2 2019 In this study, we describe the inhibitory effect of metformin in interleukin 8 (IL-8) upregulation by lithocholic acid (LCA) in HCT116 colorectal cancer (CRC) cells. Metformin 52-61 C-X-C motif chemokine ligand 8 Homo sapiens 80-84 30765814-4 2019 Metformin was demonstrated to block LCA-stimulated ROS production, in turn suppressing NF-kappaB signaling that was critical for IL-8 upregulation. Metformin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 129-133 30765814-7 2019 In conclusion, metformin inhibited NADPH oxidase, which in turn suppressed ROS production and NF-kappaB activation to prevent IL-8 upregulation stimulated by LCA; this prevention thus obstructed endothelial cell proliferation and tubelike formation. Metformin 15-24 C-X-C motif chemokine ligand 8 Homo sapiens 126-130 30520054-4 2019 Our results demonstrated that metformin significantly decreased the mRNA and protein levels of tumour necrosis factor-alpha (TNFalpha), interleukin (IL)-6, IL-8, and IL-1beta induced by TNFalpha. Metformin 30-39 C-X-C motif chemokine ligand 8 Homo sapiens 156-160 29147073-0 2017 Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line. Metformin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 21-26 29513760-6 2018 Several inflammatory molecules upregulated by tumor necrosis factor-alpha in human retinal vascular endothelial cells were markedly reduced by metformin, including nuclear factor kappa B p65 (NFkappaB p65), intercellular adhesion molecule-1 (ICAM-1), monocyte chemotactic protein-1 (MCP-1), and interleukin-8 (IL-8). Metformin 143-152 C-X-C motif chemokine ligand 8 Homo sapiens 295-308 29513760-6 2018 Several inflammatory molecules upregulated by tumor necrosis factor-alpha in human retinal vascular endothelial cells were markedly reduced by metformin, including nuclear factor kappa B p65 (NFkappaB p65), intercellular adhesion molecule-1 (ICAM-1), monocyte chemotactic protein-1 (MCP-1), and interleukin-8 (IL-8). Metformin 143-152 C-X-C motif chemokine ligand 8 Homo sapiens 310-314 29147073-5 2017 This study intended to address the role of metformin in regulation of CXCL8 expression and cell proliferation and migration. Metformin 43-52 C-X-C motif chemokine ligand 8 Homo sapiens 70-75 29147073-6 2017 Our data indicated that metformin suppressed LPS-induced CXCL8 expression in a dose-dependent manner through inhibiting NF-kappaB, but not AP-1 and C/EBP, activities under the conditions we used. Metformin 24-33 C-X-C motif chemokine ligand 8 Homo sapiens 57-62 25889494-5 2015 RESULTS: AICAR and metformin markedly reduced the IL-8 and GROalpha production induced by TNF-alpha. Metformin 19-28 C-X-C motif chemokine ligand 8 Homo sapiens 50-54 27904616-7 2016 After folic acid and metformin administration, mean of Hcy, HOMA-IR, TNF-alpha, and IL-8 decreased significantly (P < 0.05). Metformin 21-30 C-X-C motif chemokine ligand 8 Homo sapiens 84-88 22841520-5 2013 RESULTS: Compared to placebo, metformin reduced monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, monocyte chemoattractant protein-1 and interleukin-8, as well as decreased plasma C-reactive protein levels, which were accompanied by an improvement in insulin sensitivity. Metformin 30-39 C-X-C motif chemokine ligand 8 Homo sapiens 170-183 25590211-0 2015 Metformin reverts the secretion of CXCL8 induced by TNF-alpha in primary cultures of human thyroid cells: an additional indirect anti-tumor effect of the drug. Metformin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 35-40 25590211-4 2015 OBJECTIVE: This study aimed to evaluate whether metformin inhibits the secretion of CXCL8 induced by Tumor-Necrosis-Factor-alpha (TNF-alpha) in primary cultures of normal and tumor human thyroid cells as well as in thyroid cancer cell lines. Metformin 48-57 C-X-C motif chemokine ligand 8 Homo sapiens 84-89 25590211-7 2015 RESULTS: Metformin significantly and dose-dependently inhibited the TNF-alpha-induced CXCL8 secretion in both normal thyrocytes (ANOVA: F = 42.04; P < .0001) and papillary thyroid cancer cells (ANOVA: F = 21.691; P < .0001) but not in TPC-1 and BCPAP cell lines. Metformin 9-18 C-X-C motif chemokine ligand 8 Homo sapiens 86-91 25590211-8 2015 CONCLUSION: Metformin inhibits the TNF-alpha-induced CXCL8 secretion in primary cultures of normal thyroid cells and differentiated thyroid cancer cells at least of the most frequent poorly aggressive phenotype. Metformin 12-21 C-X-C motif chemokine ligand 8 Homo sapiens 53-58 25590211-10 2015 Thus, the here-reported inhibiting effect of metformin on TNF-alpha-induced CXCL8 secretion could be considered as a further indirect anticancer property of the drug. Metformin 45-54 C-X-C motif chemokine ligand 8 Homo sapiens 76-81 21316309-0 2011 Metformin modulates IL-8, IL-1beta, ICAM and IGFBP-1 expression in human endometrial stromal cells. Metformin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 20-24 23091851-8 2012 The CHD and MS patients who carried the Pro allele showed a significant metformin-induced reduction in weight, waist circumference, body mass index, and concentrations of TC, C-peptide, and cytokines, such IL-1beta, IL-6, IL-8, and TNF-alpha. Metformin 72-81 C-X-C motif chemokine ligand 8 Homo sapiens 222-226 21316309-7 2011 The negative effect of insulin on IL-8 (4.8 fold) and IL-1beta (9.3 fold) gene expression was similarly found in cells incubated with metformin. Metformin 134-143 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 16385087-4 2006 METHODS AND RESULTS: Metformin dose-dependently inhibited IL-1beta-induced release of the pro-inflammatory cytokines IL-6 and IL-8 in ECs, SMCs, and Mphis. Metformin 21-30 C-X-C motif chemokine ligand 8 Homo sapiens 126-130 21954641-1 2011 The use of metformin during the first month of treatment of patients with coronary artery disease and diabetes type 2 led to the decrease of insulin resistance and reduced activity of systemic inflammation (significant decrease in the concentrations of IL-1, IL-6, IL-8 and TNF-alpha). Metformin 11-20 C-X-C motif chemokine ligand 8 Homo sapiens 265-269 17504902-0 2007 Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells. Metformin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 52-56 17504902-5 2007 RESULTS: Metformin dose-dependently suppressed IL-1beta-induced IL-8 production, cAMP-induced mRNA expression and aromatase activity, and 5-bromo-2"-deoxyuridine incorporation in ESCs. Metformin 9-18 C-X-C motif chemokine ligand 8 Homo sapiens 64-68 11246821-7 2000 Metformin 0.1-10 mM inhibited interleukin-8 release by 20-50% (p < 0.05) and mRNA expression by 20-90% (p < 0.05). Metformin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 30-43 34626114-6 2022 The results of q-PCR analysis showed that metformin reduced NF-kappaB mediated inflammatory response including decreased level of pro-inflammatory cytokine IL-8 and increased expression of anti-inflammatory cytokine IL-10 in gut of the fish with natural aging and poly I:C-injected 6-month-old fish. Metformin 42-51 C-X-C motif chemokine ligand 8 Homo sapiens 156-160 34584119-8 2021 Moreover, metformin also triggered mRNA expression of the proinflammatory cytokines IL1B, CXCL8 and growth factor GDF15 in human uroepithelial cells. Metformin 10-19 C-X-C motif chemokine ligand 8 Homo sapiens 90-95 33649784-11 2021 The pharmacological induction of autophagy with rapamycin or metformin attenuated the pro-migratory effects of IL-8. Metformin 61-70 C-X-C motif chemokine ligand 8 Homo sapiens 111-115