PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27210058-7 2016 MTT assay and TUNEL assay revealed that metformin (4 mg/ml) and 5-FU (2.5 microg/ml) combination treatment effectively inhibited cell growth and induced apoptosis in OSCC cell lines (HSC2, HSC3 and HSC4) compared to either agent alone. Metformin 40-49 DnaJ heat shock protein family (Hsp40) member B7 Homo sapiens 189-193 26359040-1 2015 OBJECTIVE: To investigate the effect of metformin on the proliferation and cell apoptosis of oral squamous cell carcinoma (OSCC) (HSC-3, HSC-4) in vitro and in vivo. Metformin 40-49 DnaJ heat shock protein family (Hsp40) member B7 Homo sapiens 130-135 26359040-2 2015 METHODS: HSC-3, HSC-4 cells were treated with metformin at different concentration (2-50 mmol/L) for 24, 48 or 72 hours. Metformin 46-55 DnaJ heat shock protein family (Hsp40) member B7 Homo sapiens 9-14 26359040-12 2015 RESULTS: Metformin inhibited proliferation and colony formation of HSC-3, HSC-4 in a time- and dose-dependent manner. Metformin 9-18 DnaJ heat shock protein family (Hsp40) member B7 Homo sapiens 67-72 26359040-19 2015 CONCLUSIONS: Metformin could inhibit the growth of OSCC cell line (HSC-3, HSC-4) by reducing cell proliferation and increasing cell apoptosis in vitro and in vivo. Metformin 13-22 DnaJ heat shock protein family (Hsp40) member B7 Homo sapiens 67-72