PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22340218-9	2011	However, IKKalpha expression was increased after metformin treatment in both tissues.	Metformin	49-58	conserved helix-loop-helix ubiquitous kinase	Mus musculus	9-17	
30359174-6	2019	Metformin reduced levels of the NFkappaB signaling components p-IKKalpha/beta, p-NFkappaB, p-IkappaBalpha in colorectal mucosal cells.	Metformin	0-9	conserved helix-loop-helix ubiquitous kinase	Mus musculus	64-77	
34291435-4	2021	We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKalpha/beta signaling that leads to phosphorylation of Ser85 of the key mediator of CMA, Hsc70, and its activation.	Metformin	47-56	conserved helix-loop-helix ubiquitous kinase	Mus musculus	86-99	
34291435-8	2021	Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKalpha/beta-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases, such as AD, where such therapeutic intervention could be beneficial.	Metformin	61-70	conserved helix-loop-helix ubiquitous kinase	Mus musculus	76-89