PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30017187-3 2018 In human granulosa cells, it was found that metformin treatment suppressed phosphorylation of Smad1/5/9 activated by BMP-15 compared with that induced by other BMP ligands. Metformin 44-53 SMAD family member 1 Homo sapiens 94-101 30017187-5 2018 Thus, the mechanism by which metformin suppresses BMP-15-induced Smad1/5/9 phosphorylation is likely, at least in part, to be upregulation of inhibitory Smad6 expression in granulosa cells. Metformin 29-38 SMAD family member 1 Homo sapiens 65-72 28427181-4 2017 Thus, we treated human umbilical vein endothelial cells with metformin as well as other pharmacological AMPK activators and showed that activation of AMPK inhibited Smad1/5 phosphorylation and tube formation induced by BMP9. Metformin 61-70 SMAD family member 1 Homo sapiens 165-172