PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30017187-3	2018	In human granulosa cells, it was found that metformin treatment suppressed phosphorylation of Smad1/5/9 activated by BMP-15 compared with that induced by other BMP ligands.	Metformin	44-53	SMAD family member 1	Homo sapiens	94-101	
30017187-5	2018	Thus, the mechanism by which metformin suppresses BMP-15-induced Smad1/5/9 phosphorylation is likely, at least in part, to be upregulation of inhibitory Smad6 expression in granulosa cells.	Metformin	29-38	SMAD family member 1	Homo sapiens	65-72	
28427181-4	2017	Thus, we treated human umbilical vein endothelial cells with metformin as well as other pharmacological AMPK activators and showed that activation of AMPK inhibited Smad1/5 phosphorylation and tube formation induced by BMP9.	Metformin	61-70	SMAD family member 1	Homo sapiens	165-172