PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31165723-8	2019	Moreover, metformin intake reduces the number of nuclear aggregates of mutant huntingtin in the striatum.	Metformin	10-19	huntingtin	Mus musculus	78-88	
28632780-3	2017	Recent work suggests that treating invertebrate and mice HD models with metformin, a well-known AMPK activator which is used worldwide to treat type 2-diabetes, reduces mutant huntingtin from cells and alleviates many of the phenotypes associated to HD.	Metformin	72-81	huntingtin	Mus musculus	176-186	
30179155-5	2018	We furthermore show that the antidiabetic drug metformin diminishes aberrant Huntingtin protein load and fully restores both early network activity patterns and behavioral aberrations.	Metformin	47-56	huntingtin	Mus musculus	77-87	
26681807-6	2016	Similarly, AMPK activation using genetic manipulation and low-dose metformin treatment protects mouse striatal cells expressing full-length mutant Htt (mHtt), counteracting their vulnerability to stress, with reduction of soluble mHtt levels by metformin and compensation of cytotoxicity by AMPKalpha1.	Metformin	67-76	huntingtin	Mus musculus	147-150	
27225841-0	2016	Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics.	Metformin	0-9	huntingtin	Mus musculus	37-47	
27225841-6	2016	In this study, we showed that metformin rescued cells from mutant huntingtin (HTT)-induced toxicity, as indicated by reduced lactate dehydrogenase (LDH) release from cells and preserved ATP levels in cells expressing mutant HTT.	Metformin	30-39	huntingtin	Mus musculus	66-76	
27225841-6	2016	In this study, we showed that metformin rescued cells from mutant huntingtin (HTT)-induced toxicity, as indicated by reduced lactate dehydrogenase (LDH) release from cells and preserved ATP levels in cells expressing mutant HTT.	Metformin	30-39	huntingtin	Mus musculus	78-81	
27225841-6	2016	In this study, we showed that metformin rescued cells from mutant huntingtin (HTT)-induced toxicity, as indicated by reduced lactate dehydrogenase (LDH) release from cells and preserved ATP levels in cells expressing mutant HTT.	Metformin	30-39	huntingtin	Mus musculus	224-227	
27225841-7	2016	Further mechanistic study indicated that metformin activated AMP-activated protein kinase (AMPK) and that inhibition of AMPK activation reduced its protective effects on mutant HTT toxicity, suggesting that AMPK mediates the protection of metformin in HD cells.	Metformin	239-248	huntingtin	Mus musculus	177-180	
26681807-6	2016	Similarly, AMPK activation using genetic manipulation and low-dose metformin treatment protects mouse striatal cells expressing full-length mutant Htt (mHtt), counteracting their vulnerability to stress, with reduction of soluble mHtt levels by metformin and compensation of cytotoxicity by AMPKalpha1.	Metformin	67-76	huntingtin	Mus musculus	152-156	
26681807-6	2016	Similarly, AMPK activation using genetic manipulation and low-dose metformin treatment protects mouse striatal cells expressing full-length mutant Htt (mHtt), counteracting their vulnerability to stress, with reduction of soluble mHtt levels by metformin and compensation of cytotoxicity by AMPKalpha1.	Metformin	67-76	huntingtin	Mus musculus	230-234	
26681807-6	2016	Similarly, AMPK activation using genetic manipulation and low-dose metformin treatment protects mouse striatal cells expressing full-length mutant Htt (mHtt), counteracting their vulnerability to stress, with reduction of soluble mHtt levels by metformin and compensation of cytotoxicity by AMPKalpha1.	Metformin	245-254	huntingtin	Mus musculus	230-234