PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14633764-4 2003 However, what is less well appreciated is the role that the COX 2 inhibitors may play in the development of renal failure which, when it occurs in a patient on metformin, can lead to a potentially disastrous outcome. Metformin 160-169 mitochondrially encoded cytochrome c oxidase II Homo sapiens 60-65 22898050-11 2012 Metformin suppressed COX-2 and iNOS mRNA and protein expression dose dependently. Metformin 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 21-26 24011132-11 2013 The vasoactive factors: COX-2 and NOS were increased in the ovaries of the OHSS group (P<0.05 and P<0.01) and metformin normalized their expression (P<0.05); suggesting that metformin has a role preventing the increased in vascular permeability caused by the syndrome. Metformin 183-192 mitochondrially encoded cytochrome c oxidase II Homo sapiens 24-29 24011132-13 2013 These effects of metformin are mediated by inhibiting the increased of the vasoactive molecules: VEGF, COX-2 and partially NOS. Metformin 17-26 mitochondrially encoded cytochrome c oxidase II Homo sapiens 103-108 30469399-0 2018 Metformin Inhibits Migration and Invasion by Suppressing ROS Production and COX2 Expression in MDA-MB-231 Breast Cancer Cells. Metformin 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 76-80 34572149-8 2021 In addition, metformin, a potential inhibitor of TLR4, also decreased expression of COX-2 and IL-6 induced by co-incubation with IL-26 and palmitate. Metformin 13-22 mitochondrially encoded cytochrome c oxidase II Homo sapiens 84-89 31593087-5 2019 Cox proportional hazard regression analysis revealed the lower rate of admission for subjects under combination therapy (adjusted hazard ratio of 0.275; 95% confidence interval = 0.136-0.557, P < .001).Patients with RA and T2DM receiving the combination of COX-2 inhibitors and metformin were associated with lower admission rate than those on COX-2 inhibitors alone, and this effect may be attributed to the decrease in the levels of proinflammatory factors. Metformin 278-287 mitochondrially encoded cytochrome c oxidase II Homo sapiens 257-262 31205453-1 2019 This paper includes synthesis and characterization of mixed ligand complexes derived from mefenamic acid and metformin using transition metal ions such as Co(II) and Cu(II). Metformin 109-118 mitochondrially encoded cytochrome c oxidase II Homo sapiens 155-161 34257723-6 2021 Additionally, metformin inhibited cyclooxygenase (COX)-2 expression. Metformin 14-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 34-56 34257723-8 2021 Thus, the current data suggested that metformin may have potential value as a synergistic therapy targeting both the COX-2 and mTOR signaling pathways. Metformin 38-47 mitochondrially encoded cytochrome c oxidase II Homo sapiens 117-122 30469399-8 2018 At 100 microM, however, metformin reduced ICAM1 and COX2 expression, as well as reduced PGE2 production and endogenous mitochondrial ROS production while failing to significantly impact cell viability. Metformin 24-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 52-56 29385156-9 2018 CONCLUSIONS: Patients who have OA and T2DM receiving combination COX-2 inhibitors and metformin therapy associated with lower joint replacement surgery rates than those without and this may be attributable to combination therapy much more decrease pro-inflammatory factors associated than those without metformin therapy. Metformin 303-312 mitochondrially encoded cytochrome c oxidase II Homo sapiens 65-70 26896068-9 2016 Moreover, metformin enhanced the anti-inflammatory effect of 5-ASA by decreasing the gene expression of IL-1beta, IL-6, COX-2 and TNF-alpha and its receptors; TNF-R1 and TNF-R2. Metformin 10-19 mitochondrially encoded cytochrome c oxidase II Homo sapiens 120-125 28043910-0 2017 Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis. Metformin 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 75-79 28043910-5 2017 In addition, we showed the effects of metformin on the expression of genes involved in EMT through repressing the levels of COX2, PGE2 and phosphorylated STAT3. Metformin 38-47 mitochondrially encoded cytochrome c oxidase II Homo sapiens 124-128 28043910-6 2017 Furthermore, inactivating COX2 abolishes metformin"s regulatory effects and exogenously administered PGE2 is capable of enhancing STAT3 phosphorylation and expression of EMT biomarker. Metformin 41-50 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-30 28043910-7 2017 We propose that metformin represses prostate cancer EMT and metastasis through targeting the COX2/PGE2/STAT3 axis. Metformin 16-25 mitochondrially encoded cytochrome c oxidase II Homo sapiens 93-97 27619024-9 2016 The amount of COX-2 protein production was significantly decreased by metformin pretreatment (4 mM, p = 0.01). Metformin 70-79 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-19 25981877-3 2015 Metformin may harbor a pleiotropic action, (a) decreasing inflammation (via anti COX 2 pathway and other mechanism), (b) decreasing COX 2 and VEGF mediated angiogenesis, (c) increasing negative angiogenic regulation pathway by stimulating SMAD 2/3 expression either directly or via the AMPK pathway and preventing from pulmonary hypertension development and (d) diminushin oxidative stress. Metformin 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 81-86 25981877-3 2015 Metformin may harbor a pleiotropic action, (a) decreasing inflammation (via anti COX 2 pathway and other mechanism), (b) decreasing COX 2 and VEGF mediated angiogenesis, (c) increasing negative angiogenic regulation pathway by stimulating SMAD 2/3 expression either directly or via the AMPK pathway and preventing from pulmonary hypertension development and (d) diminushin oxidative stress. Metformin 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 132-137