PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34546972-13 2021 This effect of metformin is partially dependent on FOXO3 which can activate the transcription of NLRP3. Metformin 15-24 NLR family pyrin domain containing 3 Homo sapiens 97-102 32330868-0 2020 Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. Metformin 0-9 NLR family pyrin domain containing 3 Homo sapiens 96-101 34115964-0 2021 Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Metformin 0-9 NLR family pyrin domain containing 3 Homo sapiens 70-75 34115964-3 2021 We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1beta production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS. Metformin 13-22 NLR family pyrin domain containing 3 Homo sapiens 33-38 34115964-4 2021 By targeting electron transport chain complex 1 and independently of AMP-activated protein kinase (AMPK) or NF-kappaB, metformin blocked LPS-induced and ATP-dependent mitochondrial (mt) DNA synthesis and generation of oxidized mtDNA, an NLRP3 ligand. Metformin 119-128 NLR family pyrin domain containing 3 Homo sapiens 237-242 32967076-0 2020 Systemic Oxidative Stress and Visceral Adipose Tissue Mediators of NLRP3 Inflammasome and Autophagy Are Reduced in Obese Type 2 Diabetic Patients Treated with Metformin. Metformin 159-168 NLR family pyrin domain containing 3 Homo sapiens 67-72 32967076-7 2020 This downregulation of both the NLRP3 inflammasome and autophagy in VAT may be associated with the improved inflammatory profile and leukocyte homeostasis seen in obese T2D patients treated with metformin with respect to MHO subjects and endorses the cardiometabolic protective effect of this drug. Metformin 195-204 NLR family pyrin domain containing 3 Homo sapiens 32-37 34841901-9 2022 FUTURE DIRECTIONS: Among strategies to inhibit the NLRP3 inflammasome, Glyburide, Metformin, PPAR agonists and the DPP-4 inhibitor saxagliptin appear to be closest to clinical translation, as these drugs are already FDA approved for other indications. Metformin 82-91 NLR family pyrin domain containing 3 Homo sapiens 51-56 32330868-11 2020 Importantly, Metformin reduced pyroptosis-related proteins, including NLRP3, cleaved caspase-1, and the N-terminus of GSDMD. Metformin 13-22 NLR family pyrin domain containing 3 Homo sapiens 70-75 32330868-13 2020 We also discovered that Metformin suppressed the expression of TXNIP and the interaction between TXNIP and NLRP3. Metformin 24-33 NLR family pyrin domain containing 3 Homo sapiens 107-112 32330868-15 2020 In conclusion, we believe that Metformin protects against intestinal I/R injury in a TXNIP-NLRP3-GSDMD-dependent manner. Metformin 31-40 NLR family pyrin domain containing 3 Homo sapiens 91-96 23086037-7 2013 Taken together, these data suggest that NLRP3 inflammasome activation is elevated in myeloid cells from type 2 diabetic patients and that antidiabetic treatment with metformin contributes to modulation of inflammasome activation in type 2 diabetes. Metformin 166-175 NLR family pyrin domain containing 3 Homo sapiens 40-45 32410849-0 2020 Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study. Metformin 13-22 NLR family pyrin domain containing 3 Homo sapiens 113-118 31975558-2 2020 Metformin besides being an insulin sensitizer also induces autophagy; however, its effect on mitophagy and NLRP3 activation in patients with T2DM still remains elusive. Metformin 0-9 NLR family pyrin domain containing 3 Homo sapiens 107-112 31975558-6 2020 However, multivariate ANCOVA divulged that mRNA and protein expression of mitophagy markers, NLRP3 and p-AMPKalpha (T172), were significantly increased only with metformin therapy. Metformin 162-171 NLR family pyrin domain containing 3 Homo sapiens 93-98 30851273-0 2019 Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A. Metformin 0-9 NLR family pyrin domain containing 3 Homo sapiens 18-23 30851273-3 2019 This research aimed to elucidate whether and how metformin affects NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activity in oxidized low-density lipoprotein (ox-LDL) stimulated macrophages. Metformin 49-58 NLR family pyrin domain containing 3 Homo sapiens 67-103 32194991-3 2020 Although metformin reportedly inhibits mature IL-1beta secretion via NLRP3 inflammasome in macrophages of T2DM patients, it remains unclear whether it affects skin inflammation in psoriasis. Metformin 9-18 NLR family pyrin domain containing 3 Homo sapiens 69-74 32194991-6 2020 To further reveal the mechanism involved, we examined how metformin treatment affected NLRP3 inflammasome activated by TNF-alpha and IL-17A stimulation. Metformin 58-67 NLR family pyrin domain containing 3 Homo sapiens 87-92 32194991-8 2020 Furthermore, inhibitors of AMPK and SIRT1 abrogated the downregulation of caspase-1 induced by metformin treatment, indicating that AMPK and SIRT1 are essential for the inhibitory effect on NLRP3 inflammasome in NHEKs. Metformin 95-104 NLR family pyrin domain containing 3 Homo sapiens 190-195 30851273-3 2019 This research aimed to elucidate whether and how metformin affects NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activity in oxidized low-density lipoprotein (ox-LDL) stimulated macrophages. Metformin 49-58 NLR family pyrin domain containing 3 Homo sapiens 105-110 30851273-10 2019 In the results, upregulation of NLRP3 protein expression and NLRP3 inflammasome activation induced by ox-LDL treatment in macrophages were significantly attenuated by metformin treatment. Metformin 167-176 NLR family pyrin domain containing 3 Homo sapiens 32-37 30851273-10 2019 In the results, upregulation of NLRP3 protein expression and NLRP3 inflammasome activation induced by ox-LDL treatment in macrophages were significantly attenuated by metformin treatment. Metformin 167-176 NLR family pyrin domain containing 3 Homo sapiens 61-66 30851273-12 2019 Inhibition of PP2A significantly restored NLRP3 and pro-IL-1beta protein expression level downregulated by metformin in ox-LDL-stimulated macrophages. Metformin 107-116 NLR family pyrin domain containing 3 Homo sapiens 42-47 30851273-14 2019 Our data showed Metformin reduced NLRP3 protein expression and NLRP3 inflammasome activation in ox-LDL-stimulated macrophages through AMPK and PP2A. Metformin 16-25 NLR family pyrin domain containing 3 Homo sapiens 34-39 30851273-14 2019 Our data showed Metformin reduced NLRP3 protein expression and NLRP3 inflammasome activation in ox-LDL-stimulated macrophages through AMPK and PP2A. Metformin 16-25 NLR family pyrin domain containing 3 Homo sapiens 63-68 30899369-0 2019 Metformin induces the M2 macrophage polarization to accelerate the wound healing via regulating AMPK/mTOR/NLRP3 inflammasome singling pathway. Metformin 0-9 NLR family pyrin domain containing 3 Homo sapiens 106-111 30899369-9 2019 We also found that the level of relative proteins of NLRP3 inflammasome was markedly decreased after metformin treatment. Metformin 101-110 NLR family pyrin domain containing 3 Homo sapiens 53-58 30899369-10 2019 Furthermore, blockage of AMPK or activation of mTOR abolished the effects of metformin treatment on depressing NLRP3 inflammasome activation, M2 polarization and improving wound healing. Metformin 77-86 NLR family pyrin domain containing 3 Homo sapiens 111-116 30899369-11 2019 It suggested that the treatment effects of metformin on wound healing were through regulating AMPK/mTOR/NLRP3 inflammasome signaling axis. Metformin 43-52 NLR family pyrin domain containing 3 Homo sapiens 104-109 30899369-12 2019 CONCLUSION: Metformin regulated AMPK/mTOR singling pathway to inhibit NLRP3 inflammasome activation, which boosted M2 macrophage polarization to accelerate the wound healing. Metformin 12-21 NLR family pyrin domain containing 3 Homo sapiens 70-75