PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26275128-6 2015 The detoxifying/antioxidant genes activated by t-CA, especially heme oxygenase-1 (HO-1), were found to be involved in its cytoprotective effects against oxidative stress and cell injuries elicited by carcinogens tert-butylhydroperoxide and arecoline. tert-Butylhydroperoxide 212-235 heme oxygenase 1 Homo sapiens 64-80 26275128-6 2015 The detoxifying/antioxidant genes activated by t-CA, especially heme oxygenase-1 (HO-1), were found to be involved in its cytoprotective effects against oxidative stress and cell injuries elicited by carcinogens tert-butylhydroperoxide and arecoline. tert-Butylhydroperoxide 212-235 heme oxygenase 1 Homo sapiens 82-86 18812229-7 2009 Both inducible nitric oxide synthase (NOS-2) and hemoxygenase-1 (HO-1) gene expression were increased by tBH and reduced by both RES and SM pretreatments. tert-Butylhydroperoxide 105-108 heme oxygenase 1 Homo sapiens 49-69 24857917-0 2014 The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression. tert-Butylhydroperoxide 48-72 heme oxygenase 1 Homo sapiens 139-155 23350672-4 2013 Heme-hemopexin is relatively resistant to damage by ROS and retains its ability to induce the cytoprotective HO1 after exposure to tert-butylhydroperoxide, although induction is impaired, but not eliminated, by exposure to high concentrations of H(2)O(2) in vitro. tert-Butylhydroperoxide 131-154 heme oxygenase 1 Homo sapiens 109-112 31749701-9 2019 Mechanistically, we found that GAS protects HUVECs from TBHP-induced cellular apoptosis by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. tert-Butylhydroperoxide 56-60 heme oxygenase 1 Homo sapiens 157-173 18845176-4 2008 In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway. tert-Butylhydroperoxide 71-95 heme oxygenase 1 Homo sapiens 169-185 18845176-4 2008 In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway. tert-Butylhydroperoxide 71-95 heme oxygenase 1 Homo sapiens 187-191 18845176-4 2008 In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway. tert-Butylhydroperoxide 97-102 heme oxygenase 1 Homo sapiens 169-185 18845176-4 2008 In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway. tert-Butylhydroperoxide 97-102 heme oxygenase 1 Homo sapiens 187-191 18845176-6 2008 Also, puerarin up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-BHP. tert-Butylhydroperoxide 125-130 heme oxygenase 1 Homo sapiens 28-32 18021765-10 2008 These results demonstrate that the expression of HO-1 by brazilin is mediated via the PI3K/Akt and ERK pathways, and this expression inhibits t-BHP-induced cell death in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells. tert-Butylhydroperoxide 142-147 heme oxygenase 1 Homo sapiens 49-53 15589375-8 2005 Results indicate that the HO-1 and HO-2 cells are more resistant than controls to hemin and to the organic tert-butyl hydroperoxide, t-BuOOH. tert-Butylhydroperoxide 107-131 heme oxygenase 1 Homo sapiens 26-39 17295091-0 2007 Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol. tert-Butylhydroperoxide 131-154 heme oxygenase 1 Homo sapiens 0-16 17295091-2 2007 In the present work we found an increased mRNA and protein level of interleukin-11 and heme oxygenase-1 in premature senescence of WI-38 human diploid foetal lung fibroblasts induced by both tert-butylhydroperoxide and ethanol. tert-Butylhydroperoxide 191-214 heme oxygenase 1 Homo sapiens 87-103 17295091-3 2007 We tested whether interleukin-11 and heme oxygenase-1 could protect against tert-butylhydroperoxide- or ethanol-induced premature senescence when stable overexpression was established using a retroviral vector-based transduction. tert-Butylhydroperoxide 76-99 heme oxygenase 1 Homo sapiens 37-53 16636651-7 2006 In addition, expression levels of three other important antioxidant genes, heme oxygenase-1, thioredoxin reductase-1, and manganese superoxide dismutase were monitored by real-time RT-PCR following exposure to TBHP. tert-Butylhydroperoxide 210-214 heme oxygenase 1 Homo sapiens 75-91 16636651-12 2006 In addition, TBHP induced the expression of MTIIa, heme oxygenase-1, thioredoxin reductase-1, and MnSOD in both normal and MTIIa over-expressed cell lines. tert-Butylhydroperoxide 13-17 heme oxygenase 1 Homo sapiens 51-67 16482620-4 2006 RESULTS: PGG up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-butyl hydroperoxide. tert-Butylhydroperoxide 123-144 heme oxygenase 1 Homo sapiens 26-30 11581219-6 2001 Differentiated ARPE-19 cells treated with tBH or H2O2 resulted in upregulation of the HO-1 and FGFR1 transcripts. tert-Butylhydroperoxide 42-45 heme oxygenase 1 Homo sapiens 86-90 31749701-9 2019 Mechanistically, we found that GAS protects HUVECs from TBHP-induced cellular apoptosis by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. tert-Butylhydroperoxide 56-60 heme oxygenase 1 Homo sapiens 175-179 28602161-8 2017 Up-regulation of HO-1 also confers protection to HepG2 cells from tertiary butyl hydroperoxide (TBH) induced cytotoxicity. tert-Butylhydroperoxide 96-99 heme oxygenase 1 Homo sapiens 17-21 27959441-0 2017 Protective effects of Cambodian medicinal plants on tert-butyl hydroperoxide-induced hepatotoxicity via Nrf2-mediated heme oxygenase-1. tert-Butylhydroperoxide 52-76 heme oxygenase 1 Homo sapiens 118-134 27959441-9 2017 These results indicated that, of the 64 Cambodian plants, P. weberi and T. crispa exhibited hepatoprotective effects on t-BHP-induced cytotoxicity in HepG2 cells, possibly by the induction of Nrf2-mediated expression of HO-1. tert-Butylhydroperoxide 120-125 heme oxygenase 1 Homo sapiens 220-224 27183873-5 2016 Using the heme oxygenase-1 (HO-1) as a model of phase II enzyme gene, we found that methylation of Nrf2 by PRMT1 led to a moderate increase of its DNA-binding activity and transactivation, which subsequently protected cells against the tBHP-induced glutathione depletion and cell death. tert-Butylhydroperoxide 236-240 heme oxygenase 1 Homo sapiens 10-26 27183873-5 2016 Using the heme oxygenase-1 (HO-1) as a model of phase II enzyme gene, we found that methylation of Nrf2 by PRMT1 led to a moderate increase of its DNA-binding activity and transactivation, which subsequently protected cells against the tBHP-induced glutathione depletion and cell death. tert-Butylhydroperoxide 236-240 heme oxygenase 1 Homo sapiens 28-32 27190261-0 2016 Isotetrandrine ameliorates tert-butyl hydroperoxide-induced oxidative stress through upregulation of heme oxygenase-1 expression. tert-Butylhydroperoxide 27-51 heme oxygenase 1 Homo sapiens 101-117 27190261-8 2016 These results indicated that the 1R, 1"S-isotetrandrine ameliorated tert-butyl hydroperoxide-induced oxidative damage through upregulation of heme oxygenase-1 expression by the dissociation of Nrf2 from Nrf2-Keap1 complex via extracellular signal-regulated protein kinase and c-Jun NH2-terminal kinase activation and Keap1 inactivation. tert-Butylhydroperoxide 68-92 heme oxygenase 1 Homo sapiens 142-158