PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31772142-6	2019	Additionally, Ast alleviated TNF-alpha-induced ECM degradation and chondrocyte apoptosis by inhibiting the NF-kappaB signaling, suppressed TBHP-induced oxidative stress, and subsequently reduced chondrocyte apoptosis.	tert-Butylhydroperoxide	139-143	tumor necrosis factor	Mus musculus	29-38	
34409026-6	2021	TNFalpha treatment potentiated the brain endothelial erythrophagocytosis of tBHP-RBCs in vitro.	tert-Butylhydroperoxide	76-80	tumor necrosis factor	Mus musculus	0-8	
29371164-5	2018	Thus, Avns reduced IKKbeta kinase activity in response to tert-butyl hydroperoxide (tBHP) stimulation and attenuated tBHP-induced TNFalpha and IL-1beta mRNA expression.	tert-Butylhydroperoxide	117-121	tumor necrosis factor	Mus musculus	130-138	
26205049-3	2015	Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in the livers of t-BHP-treated mice models.	tert-Butylhydroperoxide	140-145	tumor necrosis factor	Mus musculus	93-102	
17369293-2	2007	We have now studied the ability of oxidative stress induced by a synthetic oxidant tert-butyl hydroperoxide (tBHP) to induce TNF-alpha production via calcium signaling in the mouse macrophage cell line (J774).	tert-Butylhydroperoxide	83-107	tumor necrosis factor	Mus musculus	125-134	
22508061-9	2012	The effect of rapamycin on TNF-alpha release was also mimicked by the antioxidant ROS scavenger Tempol (30 muM) and partially reversed by additional application of tert-butylhydroperoxide (10 muM).	tert-Butylhydroperoxide	164-187	tumor necrosis factor	Mus musculus	27-36	
17369293-2	2007	We have now studied the ability of oxidative stress induced by a synthetic oxidant tert-butyl hydroperoxide (tBHP) to induce TNF-alpha production via calcium signaling in the mouse macrophage cell line (J774).	tert-Butylhydroperoxide	109-113	tumor necrosis factor	Mus musculus	125-134	
17369293-3	2007	The oxidant tBHP significantly increased intracellular calcium and the release of TNF-alpha in J774 cells, an effect that was reduced to control levels by inhibition of calcium signaling with verapamil, BAPTA-AM, and W-7.	tert-Butylhydroperoxide	12-16	tumor necrosis factor	Mus musculus	82-91	
17129690-3	2007	In this study, we examined the effect of the oxidant tert-butylhydroperoxide (tBHP) on mouse J774 macrophages and its ability to cause the release of the pro-inflammatory cytokine tumour necrosis factor alpha (TNF-alpha).	tert-Butylhydroperoxide	53-76	tumor necrosis factor	Mus musculus	210-219	
17129690-3	2007	In this study, we examined the effect of the oxidant tert-butylhydroperoxide (tBHP) on mouse J774 macrophages and its ability to cause the release of the pro-inflammatory cytokine tumour necrosis factor alpha (TNF-alpha).	tert-Butylhydroperoxide	78-82	tumor necrosis factor	Mus musculus	210-219	
17129690-8	2007	The production of TNF-alpha protein by J774 macrophages was mediated by a pathway involving calcium as addition of calcium antagonists inhibited the tBHP stimulated increase in the cytokine.	tert-Butylhydroperoxide	149-153	tumor necrosis factor	Mus musculus	18-27	
17129690-9	2007	Inhibitors of both PDE1 and PDE4 completely prevented the tBHP stimulated TNF-alpha release suggesting that the cAMP pathway may be important in the oxidant induced signalling pathway leading to gene expression of pro-inflammatory cytokines.	tert-Butylhydroperoxide	58-62	tumor necrosis factor	Mus musculus	74-83