PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19762915-6 2009 In normal human chondrocytes, tBHP triggered strong IRS-1 (Ser-312 and Ser-616) and ERK phosphorylation and inhibited IGF-I-induced IRS-1 (Tyr-612) and Akt phosphorylation. tert-Butylhydroperoxide 30-34 AKT serine/threonine kinase 1 Homo sapiens 152-155 21136025-0 2011 Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt. tert-Butylhydroperoxide 56-61 AKT serine/threonine kinase 1 Homo sapiens 136-139 21136025-8 2011 The pre-treatment with Cur3 decreased t-BHP-induced ERK1/2 phosphorylation and increased t-BHP-induced Akt phosporylation but did not affect the phosphorylation of p38 or JNK. tert-Butylhydroperoxide 89-94 AKT serine/threonine kinase 1 Homo sapiens 103-106 21136025-10 2011 These results suggest that the ERK1/2 and PI3K/Akt signaling pathways could be involved in the protective effects of Cur3 against t-BHP-induced damage in HUVECs. tert-Butylhydroperoxide 130-135 AKT serine/threonine kinase 1 Homo sapiens 47-50 19762915-10 2009 Chemical inhibition of ERK significantly enhanced IGF-I phosphorylation of Akt and alleviated tBHP inhibition of Akt phosphorylation. tert-Butylhydroperoxide 94-98 AKT serine/threonine kinase 1 Homo sapiens 113-116 18845176-4 2008 In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway. tert-Butylhydroperoxide 71-95 AKT serine/threonine kinase 1 Homo sapiens 161-164 18845176-4 2008 In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway. tert-Butylhydroperoxide 97-102 AKT serine/threonine kinase 1 Homo sapiens 161-164 18021765-10 2008 These results demonstrate that the expression of HO-1 by brazilin is mediated via the PI3K/Akt and ERK pathways, and this expression inhibits t-BHP-induced cell death in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells. tert-Butylhydroperoxide 142-147 AKT serine/threonine kinase 1 Homo sapiens 91-94 35464773-5 2022 Tertbutyl hydroperoxide can inhibit the expression of PREP by activating the PI3K/AKT signaling pathway at low concentrations in NP cells. tert-Butylhydroperoxide 0-23 AKT serine/threonine kinase 1 Homo sapiens 82-85 25433273-8 2015 Cell apoptosis was increasing and molecule expression of PI3K/Akt signaling pathway were up-regulated in the tert-Butyl hydroperoxide (tBHP)-injured group, the cell apoptosis and expression levels of PI3K/Akt in Na2SeO3 group were decreased. tert-Butylhydroperoxide 109-133 AKT serine/threonine kinase 1 Homo sapiens 62-65 29128606-6 2018 Further biomedical research indicated that SAAS pretreatment reduced the t-BHP induced increase of lactate dehydrogenase (LDH), intracellular reactive oxygen species (ROS), malondialdehyde (MDA) and mitochondrial membrane potential (MMP), and the decrease of key antioxidant enzymes through mitochondria antioxidative pathways via JAK2/STAT3 and PI3K/Akt/GSK-3beta signalings. tert-Butylhydroperoxide 73-78 AKT serine/threonine kinase 1 Homo sapiens 351-354 28025122-0 2017 Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways. tert-Butylhydroperoxide 42-47 AKT serine/threonine kinase 1 Homo sapiens 122-125 28110191-9 2017 Furthermore, treatment with either Akt or ERK inhibitor also decreased AA-mediated cytoprotection against t-BHP-induced cellular damage. tert-Butylhydroperoxide 106-111 AKT serine/threonine kinase 1 Homo sapiens 35-38 28110191-10 2017 Collectively, these results presented in this study indicate that AA has the protective effect against t-BHP-induced cellular damage and oxidative stress by modulating Nrf2 signaling through activating the signals of Akt and ERK. tert-Butylhydroperoxide 103-108 AKT serine/threonine kinase 1 Homo sapiens 217-220 27030608-0 2016 Exendin-4 protects HUVECs from t-BHP-induced apoptosis via PI3K/Akt-Bcl-2-caspase-3 signaling. tert-Butylhydroperoxide 31-36 AKT serine/threonine kinase 1 Homo sapiens 64-67 27030608-10 2016 Exendin-4 reversed t-BHP-mediated inhibition of Akt phosphorylation, which was abrogated by the PI3K inhibitor, wortmannin. tert-Butylhydroperoxide 19-24 AKT serine/threonine kinase 1 Homo sapiens 48-51 25433273-8 2015 Cell apoptosis was increasing and molecule expression of PI3K/Akt signaling pathway were up-regulated in the tert-Butyl hydroperoxide (tBHP)-injured group, the cell apoptosis and expression levels of PI3K/Akt in Na2SeO3 group were decreased. tert-Butylhydroperoxide 109-133 AKT serine/threonine kinase 1 Homo sapiens 205-208 25433273-8 2015 Cell apoptosis was increasing and molecule expression of PI3K/Akt signaling pathway were up-regulated in the tert-Butyl hydroperoxide (tBHP)-injured group, the cell apoptosis and expression levels of PI3K/Akt in Na2SeO3 group were decreased. tert-Butylhydroperoxide 135-139 AKT serine/threonine kinase 1 Homo sapiens 62-65 25433273-8 2015 Cell apoptosis was increasing and molecule expression of PI3K/Akt signaling pathway were up-regulated in the tert-Butyl hydroperoxide (tBHP)-injured group, the cell apoptosis and expression levels of PI3K/Akt in Na2SeO3 group were decreased. tert-Butylhydroperoxide 135-139 AKT serine/threonine kinase 1 Homo sapiens 205-208 25433273-10 2015 Apoptosis induced by tBHP in chondrocyte might be mediated via up-regulation of PI3K/Akt, Na2SeO3 has an effect of anti-apoptosis by down-regulating of PI3K/Akt signaling pathway. tert-Butylhydroperoxide 21-25 AKT serine/threonine kinase 1 Homo sapiens 85-88 25433273-10 2015 Apoptosis induced by tBHP in chondrocyte might be mediated via up-regulation of PI3K/Akt, Na2SeO3 has an effect of anti-apoptosis by down-regulating of PI3K/Akt signaling pathway. tert-Butylhydroperoxide 21-25 AKT serine/threonine kinase 1 Homo sapiens 157-160