PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29372310-12 2019 D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor. tert-Butylhydroperoxide 31-36 thymoma viral proto-oncogene 1 Mus musculus 96-99 31006097-0 2019 Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway. tert-Butylhydroperoxide 26-31 thymoma viral proto-oncogene 1 Mus musculus 107-110 32377518-0 2020 Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway. tert-Butylhydroperoxide 36-41 thymoma viral proto-oncogene 1 Mus musculus 108-111 32377518-10 2020 BXXD promoted the phosphorylation of AKT and FOXO1 in t-BHP-induced MIN6 cells. tert-Butylhydroperoxide 54-59 thymoma viral proto-oncogene 1 Mus musculus 37-40 32377518-13 2020 Conclusion: BXXD protected MIN6 cells against t-BHP-induced apoptosis and improved insulin secretory function through modulation of the PI3K/AKT pathway and the downstream FOXO1, thus suggesting a novel therapeutic approach for type 2 diabetes mellitus (T2DM). tert-Butylhydroperoxide 46-51 thymoma viral proto-oncogene 1 Mus musculus 141-144 29372310-12 2019 D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor. tert-Butylhydroperoxide 31-36 thymoma viral proto-oncogene 1 Mus musculus 165-168 26576227-6 2015 Furthermore, Lico A treatment markedly attenuated t-BHP-induced oxidative damage, which was reduced by treatment with PI3K/Akt, ERK, and HO-1 inhibitors. tert-Butylhydroperoxide 50-55 thymoma viral proto-oncogene 1 Mus musculus 123-126 26138884-7 2015 A 4 hours treatment with either LPS (1microg/ml) or tert-butylhydroperoxide (tBOOH, 5 microM) significantly stimulated Na(+)/H(+) exchanger activity in both genotypes, effects, however, significantly blunted in akt1(-/-) DCs. tert-Butylhydroperoxide 52-75 thymoma viral proto-oncogene 1 Mus musculus 211-215 26138884-7 2015 A 4 hours treatment with either LPS (1microg/ml) or tert-butylhydroperoxide (tBOOH, 5 microM) significantly stimulated Na(+)/H(+) exchanger activity in both genotypes, effects, however, significantly blunted in akt1(-/-) DCs. tert-Butylhydroperoxide 77-82 thymoma viral proto-oncogene 1 Mus musculus 211-215 26576227-7 2015 Therefore, Lico A might have a protective role against t-BHP-induced cytotoxicity by modulating HO-1 and by scavenging ROS via the activation of the PI3K/Akt and ERK/Nrf2 signaling pathways. tert-Butylhydroperoxide 55-60 thymoma viral proto-oncogene 1 Mus musculus 154-157