PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29372310-12	2019	D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor.	tert-Butylhydroperoxide	31-36	thymoma viral proto-oncogene 1	Mus musculus	96-99	
32377518-0	2020	Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway.	tert-Butylhydroperoxide	36-41	thymoma viral proto-oncogene 1	Mus musculus	108-111	
32377518-10	2020	BXXD promoted the phosphorylation of AKT and FOXO1 in t-BHP-induced MIN6 cells.	tert-Butylhydroperoxide	54-59	thymoma viral proto-oncogene 1	Mus musculus	37-40	
32377518-13	2020	Conclusion: BXXD protected MIN6 cells against t-BHP-induced apoptosis and improved insulin secretory function through modulation of the PI3K/AKT pathway and the downstream FOXO1, thus suggesting a novel therapeutic approach for type 2 diabetes mellitus (T2DM).	tert-Butylhydroperoxide	46-51	thymoma viral proto-oncogene 1	Mus musculus	141-144	
31006097-0	2019	Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway.	tert-Butylhydroperoxide	26-31	thymoma viral proto-oncogene 1	Mus musculus	107-110	
29372310-12	2019	D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor.	tert-Butylhydroperoxide	31-36	thymoma viral proto-oncogene 1	Mus musculus	165-168	
26576227-6	2015	Furthermore, Lico A treatment markedly attenuated t-BHP-induced oxidative damage, which was reduced by treatment with PI3K/Akt, ERK, and HO-1 inhibitors.	tert-Butylhydroperoxide	50-55	thymoma viral proto-oncogene 1	Mus musculus	123-126	
26576227-7	2015	Therefore, Lico A might have a protective role against t-BHP-induced cytotoxicity by modulating HO-1 and by scavenging ROS via the activation of the PI3K/Akt and ERK/Nrf2 signaling pathways.	tert-Butylhydroperoxide	55-60	thymoma viral proto-oncogene 1	Mus musculus	154-157	
26138884-7	2015	A 4 hours treatment with either LPS (1microg/ml) or tert-butylhydroperoxide (tBOOH, 5 microM) significantly stimulated Na(+)/H(+) exchanger activity in both genotypes, effects, however, significantly blunted in akt1(-/-) DCs.	tert-Butylhydroperoxide	52-75	thymoma viral proto-oncogene 1	Mus musculus	211-215	
26138884-7	2015	A 4 hours treatment with either LPS (1microg/ml) or tert-butylhydroperoxide (tBOOH, 5 microM) significantly stimulated Na(+)/H(+) exchanger activity in both genotypes, effects, however, significantly blunted in akt1(-/-) DCs.	tert-Butylhydroperoxide	77-82	thymoma viral proto-oncogene 1	Mus musculus	211-215