PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33714955-4 2021 In this study, we demonstrated that the eIF2-alpha/ATF4/CHOP branch of unfolded protein response (UPR) was activated in human trabecular meshwork cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure. tert-Butylhydroperoxide 165-189 DNA damage inducible transcript 3 Homo sapiens 56-60 33714955-4 2021 In this study, we demonstrated that the eIF2-alpha/ATF4/CHOP branch of unfolded protein response (UPR) was activated in human trabecular meshwork cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure. tert-Butylhydroperoxide 191-195 DNA damage inducible transcript 3 Homo sapiens 56-60 24394546-9 2014 NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50. tert-Butylhydroperoxide 58-63 DNA damage inducible transcript 3 Homo sapiens 83-87 18278507-8 2008 GRP-78 and GADD153 mRNA and protein expression in cultured RPE cells were significantly upregulated by treatment with tBH. tert-Butylhydroperoxide 118-121 DNA damage inducible transcript 3 Homo sapiens 11-18 18278507-9 2008 CONCLUSION: tBH increases oxidative stress, increases accumulation of ROS in the ER, and upregulates expression of GRP-78 and GADD153. tert-Butylhydroperoxide 12-15 DNA damage inducible transcript 3 Homo sapiens 126-133