PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29066411-8 2018 Collectively, GA effectively protects against t-BHP-induced hepatotoxicity via inducing ERK/Nrf2-mediated antioxidative signaling pathway. tert-Butylhydroperoxide 46-51 mitogen-activated protein kinase 1 Homo sapiens 88-91 31221142-0 2019 ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress. tert-Butylhydroperoxide 106-126 mitogen-activated protein kinase 1 Homo sapiens 0-3 29066411-0 2018 Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response. tert-Butylhydroperoxide 52-76 mitogen-activated protein kinase 1 Homo sapiens 115-118 29804278-8 2018 The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway. tert-Butylhydroperoxide 81-86 mitogen-activated protein kinase 1 Homo sapiens 272-275 29804278-8 2018 The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway. tert-Butylhydroperoxide 81-86 mitogen-activated protein kinase 1 Homo sapiens 276-280 28110191-9 2017 Furthermore, treatment with either Akt or ERK inhibitor also decreased AA-mediated cytoprotection against t-BHP-induced cellular damage. tert-Butylhydroperoxide 106-111 mitogen-activated protein kinase 1 Homo sapiens 42-45 28982598-6 2017 Accordingly, Mlg might exhibit a protective role against t-BHP-triggered cytotoxicity via the activation of the AMPK/GSK3beta- and ERK-Nrf2 signaling pathways. tert-Butylhydroperoxide 57-62 mitogen-activated protein kinase 1 Homo sapiens 131-134 28982598-0 2017 Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3beta and ERK activation. tert-Butylhydroperoxide 31-36 mitogen-activated protein kinase 1 Homo sapiens 116-119 28982598-5 2017 Furthermore, Mlg exposure significantly lessened t-BHP-induced cytotoxicity and ROS production which were evidently abolished by treatment with AMPK and ERK inhibitors and Nrf2 siRNA. tert-Butylhydroperoxide 49-54 mitogen-activated protein kinase 1 Homo sapiens 153-156 28110191-10 2017 Collectively, these results presented in this study indicate that AA has the protective effect against t-BHP-induced cellular damage and oxidative stress by modulating Nrf2 signaling through activating the signals of Akt and ERK. tert-Butylhydroperoxide 103-108 mitogen-activated protein kinase 1 Homo sapiens 225-228 29152617-0 2015 Bacopa monnieri protects SH-SY5Y cells against tert-Butyl hydroperoxide-induced cell death via the ERK and PI3K pathways. tert-Butylhydroperoxide 47-71 mitogen-activated protein kinase 1 Homo sapiens 99-102 29152617-9 2015 Conclusion: These results suggest that BM by activation of ERK/MAPK and PI3K/Akt signaling pathways protects SH-SY5Y cells from TBHP-induced cell death. tert-Butylhydroperoxide 128-132 mitogen-activated protein kinase 1 Homo sapiens 59-62 29152617-9 2015 Conclusion: These results suggest that BM by activation of ERK/MAPK and PI3K/Akt signaling pathways protects SH-SY5Y cells from TBHP-induced cell death. tert-Butylhydroperoxide 128-132 mitogen-activated protein kinase 1 Homo sapiens 63-67 19762915-6 2009 In normal human chondrocytes, tBHP triggered strong IRS-1 (Ser-312 and Ser-616) and ERK phosphorylation and inhibited IGF-I-induced IRS-1 (Tyr-612) and Akt phosphorylation. tert-Butylhydroperoxide 30-34 mitogen-activated protein kinase 1 Homo sapiens 84-87 20100471-7 2010 OA ameliorated the oxidative injury induced by tBHP through increasing the generation of antioxidant (glutathione) and the expression of key antioxidant enzymes mediated by nuclear factorerythroid 2 p45-related factor 2 (Nrf2), in which process, activation of JNK and ERK, but not p38, was involved. tert-Butylhydroperoxide 47-51 mitogen-activated protein kinase 1 Homo sapiens 268-271 20100471-9 2010 OA probably functions mainly through indirect biological effect and protects QZG cells against cytotoxicity induced by tBHP through increasing the generation of antioxidant and the expression of oxidative stress sensitive transcription factor-Nrf2, and MAP kinases, mainly JNK and ERK. tert-Butylhydroperoxide 119-123 mitogen-activated protein kinase 1 Homo sapiens 281-284 24857917-0 2014 The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression. tert-Butylhydroperoxide 48-72 mitogen-activated protein kinase 1 Homo sapiens 121-124 19762915-10 2009 Chemical inhibition of ERK significantly enhanced IGF-I phosphorylation of Akt and alleviated tBHP inhibition of Akt phosphorylation. tert-Butylhydroperoxide 94-98 mitogen-activated protein kinase 1 Homo sapiens 23-26 18021765-10 2008 These results demonstrate that the expression of HO-1 by brazilin is mediated via the PI3K/Akt and ERK pathways, and this expression inhibits t-BHP-induced cell death in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells. tert-Butylhydroperoxide 142-147 mitogen-activated protein kinase 1 Homo sapiens 99-102 19603178-9 2009 When challenged with oxidative stress (250 microM t-butylhydroperoxide), VEGF expression and secretion increases and the influence of the MAPK changes: While p38 still accounts for about 30% of the secretion, Erk shows a similar influence. tert-Butylhydroperoxide 50-70 mitogen-activated protein kinase 1 Homo sapiens 138-142 19603178-9 2009 When challenged with oxidative stress (250 microM t-butylhydroperoxide), VEGF expression and secretion increases and the influence of the MAPK changes: While p38 still accounts for about 30% of the secretion, Erk shows a similar influence. tert-Butylhydroperoxide 50-70 mitogen-activated protein kinase 1 Homo sapiens 209-212 18666426-7 2008 It was found that genistein, at 1 microM, diminished t-BHP-induced down-regulation of the IGF-I receptor, Shc, Sos and phosphorylated ERK1/ERK2 expression in fibroblasts. tert-Butylhydroperoxide 53-58 mitogen-activated protein kinase 1 Homo sapiens 139-143 18666426-9 2008 These results suggest that the mechanism of the protective effect of genistein on collagen biosynthesis in t-BHP-treated fibroblasts may be due to prevention of disturbances in the IGF-I receptor-mediated, ERK1/ERK2-associated signaling pathway evoked by the oxidant. tert-Butylhydroperoxide 107-112 mitogen-activated protein kinase 1 Homo sapiens 211-215 16028365-5 2005 Our data from this t-BHP study also showed increased p38 MAP kinase and ERK activity; however, interestingly, t-BHP showed no influence on JNK. tert-Butylhydroperoxide 19-24 mitogen-activated protein kinase 1 Homo sapiens 53-56 16705147-3 2006 Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK. tert-Butylhydroperoxide 29-52 mitogen-activated protein kinase 1 Homo sapiens 133-136 16705147-3 2006 Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK. tert-Butylhydroperoxide 54-58 mitogen-activated protein kinase 1 Homo sapiens 133-136 16028365-5 2005 Our data from this t-BHP study also showed increased p38 MAP kinase and ERK activity; however, interestingly, t-BHP showed no influence on JNK. tert-Butylhydroperoxide 19-24 mitogen-activated protein kinase 1 Homo sapiens 72-75 16028365-6 2005 Pretreatment with the p38 MAP kinase inhibitor, SB203580 and the ERK1/2 inhibitor, PD98059, prevented t-BHP-induced increases in p65 translocation, NF-kappaB luciferase activity, and phospho-IKKalpha/beta. tert-Butylhydroperoxide 102-107 mitogen-activated protein kinase 1 Homo sapiens 22-25 16028365-7 2005 Data suggested that t-BHP induces NF-kappaB activation through the IKK pathway, which involves p38 MAPK and ERK activation. tert-Butylhydroperoxide 20-25 mitogen-activated protein kinase 1 Homo sapiens 95-98 16028365-7 2005 Data suggested that t-BHP induces NF-kappaB activation through the IKK pathway, which involves p38 MAPK and ERK activation. tert-Butylhydroperoxide 20-25 mitogen-activated protein kinase 1 Homo sapiens 108-111